KEGG ENZYME: 2.7.1.224

ENZYME: 2.7.1.224

Entry

EC 2.7.1.224                Enzyme

Name

cytidine diphosphoramidate kinase

Class

Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor

Sysname

ATP:cytidine 5'-diphosphoramidate 3'-phosphotransferase

Reaction(IUBMB)

ATP + cytidine 5'-diphosphoramidate = ADP + cytidine 3'-phospho-5'-diphosphoramidate [RN:R12246]

Reaction(KEGG)

R12246

Substrate

ATP [CPD:C00002];
cytidine 5'-diphosphoramidate [CPD:C22031]

Product

ADP [CPD:C00008];
cytidine 3'-phospho-5'-diphosphoramidate [CPD:C22032]

Comment

The enzyme, characterized from the bacterium Campylobacter jejuni, is involved in formation of a unique O-methyl phosphoramidate modification on specific sugar residues within the bacterium's capsular polysaccharides.

History

EC 2.7.1.224 created 2018

Orthology

K23148

cytidine diphosphoramidate kinase

Genes

PMK:

MDS_1833

PFO:	Pfl01_5510(cysC)

PCH:	EY04_30545

PCZ:	PCL1606_01930

PCP:	JM49_01225

PCHP:

C4K32_6094

PSEM:

TO66_30400

PFIT:

KJY40_29480

PHOM:

KJF94_05585

PCHE:

QYM18_22745

AGZ:	M0C34_07895

MMT:	Metme_1178

OME:	OLMES_3121

AHA:

AHA_4157

AEO:	O23A_p3858

ADH:	CK627_03040

THO:	SP60_02255

BMK:

DM80_2565

BBRO:

BAU06_24715

ACHR:

C2U31_03820

ACHB:

DVB37_27180

CDN:	BN940_10761

RSB:	RS694_17675

OTR:	OTERR_09300(cysC)

REN:	EF513_06965

RBM:

TEF_17265

MGY:	MGMSRv2__3431(cysC)

MAGX:

XM1_0908 XM1_2457

THAR:

T8K17_08575

PEL:	SAR11G3_00128

HHE:	HH_1438(cysC)

HBL:	XJ32_09990

HAD:	CDV25_01360

HCL:	NCTC13205_00574(cysC)

HWI:	A0Z60_07465 A0Z60_07470

HPUL:

NCTC13154_00535(cysC)

WSU:	WS2182(CYSC)

CJE:	Cj1415c(cysC)

CJB:	BN148_1415c(cysC)

CJJ:	CJJ81176_1414

CJU:

C8J_0653

CJN:	ICDCCJ07001_1350

CJI:	CJSA_1346(cysC)

CJM:	CJM1_0668(cysC)

CJP:	A911_06885

CJEJ:

N564_01412

CJEU:

N565_01452

CJEN:

N755_01449

CJEI:

N135_01504

CJER:

H730_08030

CJV:	MTVDSCj20_0708

CJY:	QZ67_01550(cysC)

CJQ:	UC78_1357(cysC)

CJW:	PJ18_07230

CJD:	JJD26997_1748

CJZ:	M635_02750

CJX:	BN867_07020 BN867_13980

CFF:	CFF8240_1627

CFT:	CFF04554_1629

CFV:	CFVI03293_1651

CFX:	CFV97608_1754

CFZ:

CSG_17610

CAMP:

CFT03427_1579

CFP:	CR44_08025

CLA:

CLA_0317

CLN:	UPTC3659_1403

CLL:	CONCH_1267

CCOL:

BN865_14230

CCF:

YSQ_05920

CCY:

YSS_03170

CCOI:

YSU_05570

CIS:

CINS_0308

CVO:

CVOL_1296

CSM:	CSUB8521_0349

CSF:	CSUB8523_0331

CHYO:

CHH_1591

CHV:	CHELV3228_0537(cysC)

CCUN:

CCUN_0686(cysC)

CHW:	A2J15_004820

CUX:	CUP3940_1154(cysC)

CINF:

CINF_1342(cysC) CINF_1600

CNV:	CNZW441b_0364(cysC1) CNZW441b_1160(cysC2)

CVU:	CVULP_0475(cysC)

AHS:	AHALO_2561

GLO:

Glov_3388

DSD:	GD606_13330

DVM:

DvMF_0018

CLIH:

KPS_000029

DOA:	AXF15_00635

MAI:

MICA_1010

PIH:	UB51_00285

RUK:	A4V00_01750

AMUR:

ADH66_07325

CLE:	Clole_3579

SSYI:

EKG83_20815

LED:	BBK82_30200

PMAD:

BAY61_25145

PMF:	P9303_29461

FPOL:

ERS445057_00339(sat_cysC)

NVA:	G3M78_01010(cysC)

HALY:

HYG82_02835

» show all

Reference

1 [PMID:29578334]

Authors

Taylor ZW, Raushel FM

Title

Cytidine Diphosphoramidate Kinase: An Enzyme Required for the Biosynthesis of the O-Methyl Phosphoramidate Modification in the Capsular Polysaccharides of Campylobacter jejuni.

Journal

Biochemistry 57:2238-2244 (2018)
DOI:10.1021/acs.biochem.8b00279

Sequence

[cje:Cj1415c]

Other DBs

ExplorEnz - The Enzyme Database:

2.7.1.224

IUBMB Enzyme Nomenclature:

2.7.1.224

ExPASy - ENZYME nomenclature database:

2.7.1.224

BRENDA, the Enzyme Database:

2.7.1.224

DBGET integrated database retrieval system