KEGG ENZYME: 2.7.1.226

ENZYME: 2.7.1.226

Entry

EC 2.7.1.226                Enzyme

Name

L-serine kinase (ADP);
serK (gene name)

Class

Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor

Sysname

ADP:L-serine 3-phosphotransferase

Reaction(IUBMB)

ADP + L-serine = AMP + O-phospho-L-serine [RN:R12342]

Reaction(KEGG)

R12342

Substrate

ADP [CPD:C00008];
L-serine [CPD:C00065]

Product

AMP [CPD:C00020];
O-phospho-L-serine [CPD:C01005]

Comment

The enzyme, characterized in the hyperthermophilic archaeon Thermococcus kodakarensis, participates in L-cysteine biosynthesis.

History

EC 2.7.1.226 created 2019

Pathway

ec00270

Cysteine and methionine metabolism

ec01100

Metabolic pathways

Orthology

K23370

L-serine kinase (ADP)

Genes

XBV:

XBW1_4662

PRG:	RB151_043990

SPSW:

Sps_04804

LLO:

LLO_2374

PPIC:

PhaeoP14_00143

MTT:	Ftrac_2662

PFU:

PF0380

PFI:

PFC_00865

PHO:	PH0530(PH0530)

PAB:

PAB1362

PYN:

PNA2_1158

PYA:	PYCH_19090

PYS:

Py04_0575

PYC:	TQ32_01700

TKO:

TK0378

TON:

TON_0620

TGA:

TGAM_1907

TSI:

TSIB_0895

TBA:	TERMP_00746

THE:

GQS_01905

THA:

TAM4_25

THM:

CL1_0055

TLT:

OCC_10970

THS:

TES1_0806

TNU:

BD01_0459

TEU:

TEU_09925

TGY:	X802_02265

THV:	ADU37_CDS07610

TCH:	CHITON_1378

TPEP:

A0127_02430

TGG:	A3K92_01295

TCE:	A3L02_04290

TBS:	A3L01_03805

THH:	CDI07_03730

TSL:	A3L11_07800

TTD:	A3L14_05650

TPRF:

A3L09_00460

TRL:	A3L10_02740

TPAF:

A3L08_07070

THY:	A3L12_05175

TIC:	FH039_07335

TCQ:	TIRI35C_1009

THEM:

FPV09_01850

THEI:

K1720_07630

PPAC:

PAP_07195

NAC:	AQV86_04835

ACJ:

ACAM_0517

SMR:

Smar_0555

SHC:	Shell_0238

DKA:

DKAM_0858

DFD:	Desfe_0944

DMU:	Desmu_0904

TAG:

Tagg_1147

IAG:	Igag_0323 Igag_1782

THG:	TCELL_0807

HBU:

Hbut_1584

PFM:	Pyrfu_0683

PDL:	Pyrde_0769

STO:

STK_14020

SOH:	D1869_07900

MSE:

Msed_2111

MCN:

Mcup_0176

MHK:	DFR87_07930

MPRU:

DFR88_07600

MTEN:

GWK48_04230

AHO:

Ahos_0573

ABRI:

DFR85_08645

SAZO:

D1868_04940

STEP:

IC006_1932

PCL:

Pcal_0721

TPE:	Tpen_1066 Tpen_1604

THB:	N186_05155

TCB:	TCARB_0094

THF:	MA03_04400

THEL:

IG193_02390

ASC:

ASAC_0963

CLG:	Calag_0596

CSU:	CSUB_C0252

CCAI:

NAS2_1427

BARB:

AOA66_1092

» show all

Reference

1 [PMID:27857065]

Authors

Makino Y, Sato T, Kawamura H, Hachisuka SI, Takeno R, Imanaka T, Atomi H

Title

An archaeal ADP-dependent serine kinase involved in cysteine biosynthesis and serine metabolism.

Journal

Nat Commun 7:13446 (2016)
DOI:10.1038/ncomms13446

Sequence

[tko:TK0378]

Reference

2 [PMID:28358477]

Authors

Nagata R, Fujihashi M, Kawamura H, Sato T, Fujita T, Atomi H, Miki K

Title

Structural Study on the Reaction Mechanism of a Free Serine Kinase Involved in Cysteine Biosynthesis.

Journal

ACS Chem Biol 12:1514-1523 (2017)
DOI:10.1021/acschembio.7b00064

Sequence

[tko:TK0378]

Other DBs

ExplorEnz - The Enzyme Database:

2.7.1.226

IUBMB Enzyme Nomenclature:

2.7.1.226

ExPASy - ENZYME nomenclature database:

2.7.1.226

BRENDA, the Enzyme Database:

2.7.1.226

DBGET integrated database retrieval system