KEGG   ENZYME: 2.7.1.235
Entry
EC 2.7.1.235                Enzyme                                 
Name
lipopolysaccharide core heptose(I) kinase;
WaaP;
RfaP
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
Sysname
ATP:an alpha-Hep-(1->3)-alpha-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-[lipid A] heptoseI 4-O-phosphotransferase
Reaction(IUBMB)
ATP + an alpha-Hep-(1->3)-alpha-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-[lipid A] = ADP + an alpha-Hep-(1->3)-4-O-phospho-alpha-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-[lipid A] [RN:R12951]
Reaction(KEGG)
R12951(G)
Substrate
ATP [CPD:C00002];
alpha-Hep-(1->3)-alpha-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-[lipid A]
Product
ADP [CPD:C00008];
alpha-Hep-(1->3)-4-O-phospho-alpha-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-[lipid A]
Comment
The enzyme catalyses the phosphorylation of L-glycero-D-manno-heptose I (the first heptose added to the lipid, Hep I) in the biosynthesis of the inner core oligosaccharide of the lipopolysaccharide (endotoxin) of some Gram-negative bacteria.
History
EC 2.7.1.235 created 2021
Orthology
K02848  lipopolysaccharide core heptose(I) kinase
Genes
ECO: b3630(waaP)
ECJ: JW3605(rfaP)
ECD: ECDH10B_3812(rfaP)
EBW: BWG_3321(rfaP)
ECOK: ECMDS42_3064(rfaP)
ECOC: C3026_19675
ECE: Z5054(waaP)
ECS: ECs_4505(waaP)
ECF: ECH74115_5000(rfaP)
ETW: ECSP_4624(waaP)
ELX: CDCO157_4242
EOI: ECO111_4452(rfaP)
EOJ: ECO26_4970(rfaP)
EOH: ECO103_4552(rfaP)
ECOO: ECRM13514_4619(waaP)
ECOH: ECRM13516_4417(waaP)
ESL: O3K_00690
ESO: O3O_24980
ESM: O3M_00720
ECK: EC55989_4094(waaP)
ECG: E2348C_3878(rfaP)
EOK: G2583_4366(rfaP)
ELR: ECO55CA74_20935
ELH: ETEC_3871
ECW: EcE24377A_4131(rfaP)
EUN: UMNK88_4414
ECP: ECP_3728
ENA: ECNA114_3775(rfaP)
ECOS: EC958_4037(rfaP)
ECV: APECO1_2828(rfaP)
ECOA: APECO78_21980
ECX: EcHS_A3839(rfaP)
ECM: EcSMS35_3965(rfaP)
ECY: ECSE_3910
ECR: ECIAI1_3800(waaP)
ECQ: ECED1_4313(waaP)
EUM: ECUMN_4144(waaP)
ECT: ECIAI39_4148(waaP)
EOC: CE10_4187(rfaP)
EBR: ECB_03487(waaP)
ECOB: C3029_22280
EBL: ECD_03487(waaP)
EBE: B21_03439(rfaP)
EBD: ECBD_0096
ECI: UTI89_C4173(rfaP)
EIH: ECOK1_4071(rfaP)
ECZ: ECS88_4044(waaP)
ECC: c4454(rfaP)
ELO: EC042_3937(rfaP)
ELN: NRG857_18045
ESE: ECSF_3465
ECL: EcolC_0081
EKO: EKO11_0093
EKF: KO11_04550(rfaP)
EAB: ECABU_c40690
EDH: EcDH1_0075
EDJ: ECDH1ME8569_3515(rfaP)
ELU: UM146_18305
ELW: ECW_m3906(waaP)
ELL: WFL_19090(rfaP)
ELC: i14_4116(rfaP)
ELD: i02_4116(rfaP)
ELP: P12B_c3758(waaP)
ELF: LF82_1853(rfaP)
ECOL: LY180_18695
ECOI: ECOPMV1_03963(rfaP)
ECOJ: P423_20160
EFE: EFER_3921(waaP)
EAL: EAKF1_ch2312(rfaP)
EMA: C1192_17480
ESZ: FEM44_10905(rfaP)
ERUY: OSH18_13565(rfaP)
STY: STY4073(waaP)
STT: t3797(waaP)
SEX: STBHUCCB_40090
SENT: TY21A_19295
STM: STM3721(rfaP)
SEO: STM14_4482(rfaP)
SEV: STMMW_37101
SEY: SL1344_3687(rfaP)
SEM: STMDT12_C37780
SEJ: STMUK_3707(rfaP)
SEB: STM474_3894(rfaP)
SEF: UMN798_4041(rfaP)
SETU: STU288_18800
SETC: CFSAN001921_21840
SENR: STMDT2_36071(rfaP)
SEND: DT104_37051(waaP)
SENI: CY43_19305
SEEN: SE451236_02315
SPT: SPA3573(waaP)
SEK: SSPA3336
SPQ: SPAB_04618
SEI: SPC_3803(waaP)
SEC: SCH_3644(rfaP)
SEH: SeHA_C4046
SHB: SU5_04198
SENH: CFSAN002069_13435
SEEH: SEEH1578_04690
SEE: SNSL254_A4001
SENN: SN31241_1590
SEW: SeSA_A3920
SEA: SeAg_B3938
SENS: Q786_18195
SED: SeD_A4108
SEG: SG3710(rfaP)
SEL: SPUL_3843(rfaP)
SEGA: SPUCDC_3829(rfaP)
SET: SEN3543(rfaP)
SENA: AU38_18095
SENO: AU37_18285
SENV: AU39_18290
SENQ: AU40_20375
SENL: IY59_18730
SENJ: CFSAN001992_15045
SEEC: CFSAN002050_25575
SEEB: SEEB0189_001260
SEEP: I137_18435
SENB: BN855_38160
SENE: IA1_18090
SENC: SEET0819_02365
SES: SARI_03920
SBG: SBG_3303(waaP)
SBZ: A464_3798
SBV: N643_16425
SALZ: EOS98_00625(rfaP)
SFL: SF3667(waaP)
SFX: S4101(waaP)
SFV: SFV_3901(waaP)
SFE: SFxv_3996
SFN: SFy_5230
SFS: SFyv_5305
SFT: NCTC1_03962(waaP)
SSN: SSON_3777(waaP)
SBO: SBO_3632(rfaP)
SBC: SbBS512_E4055(rfaP)
SDY: SDY_4060(waaP)
SDZ: Asd1617_05311
SHQ: A0259_22015
KMI: VW41_00225
CRO: ROD_41871(rfaP)
CKO: CKO_05087
CFD: CFNIH1_05755
CBRA: A6J81_17805
CWE: CO701_22675
CYO: CD187_00555
CPOT: FOB25_11945(rfaP)
CFQ: C2U38_26480
CSED: JY391_00560(rfaP)
CAMA: F384_19610
CAF: AL524_02375
CIF: AL515_00660
CFAR: CI104_00555
CIR: C2U53_09005
CIE: AN232_05060
CPAR: CUC49_18685
CTEL: GBC03_03785(rfaP)
CITZ: E4Z61_17575(rfaP)
CARS: E1B03_25605(rfaP)
CIX: M4I31_00580(rfaP)
CIB: HF677_000490(rfaP)
CENS: P2W74_00425(rfaP)
EBT: EBL_c39030(rfaP)
CNT: JT31_12175
CEM: LH23_05580
CEN: LH86_05525
CLAP: NCTC11466_04534(rfaP)
PGE: LG71_03335
KCO: BWI95_08425
KOT: EH164_00510(rfaP)
KOB: HF650_00620(rfaP)
KIE: NCTC12125_03935(rfaP)
KAS: KATP_01350(waaP)
KLU: K7B04_06115(rfaP)
KCY: RIN60_00820(rfaP)
LPNU: KQ929_20010(rfaP)
BAGE: BADSM9389_41100
SYM: K6K13_20185(rfaP)
AHN: NCTC12129_04884(waaP)
IZH: FEM41_06075(rfaP)
PSGC: G163CM_37040(rfaP)
SCOL: KFZ77_18440(rfaP)
PVJ: LMA04_11925(rfaP)
SUPE: P0H77_00890(rfaP)
EBF: D782_0096
EBB: F652_3470(waaP)
PPAR: A8F97_19570
PWS: A7983_08675
PPAV: LOZ86_01640(rfaP)
PQU: IG609_019385(rfaP)
PCAC: OI450_17290(rfaP)
BGJ: AWC36_19630
BRB: EH207_15355(rfaP)
BNG: EH206_00935(rfaP)
BIZ: HC231_00920(rfaP)
PSI: S70_10780
PSX: DR96_1047(rfaP)
PSTA: BGK56_13710
PTHA: OI982_12445(rfaP)
PRG: RB151_044350(rfaP)
PALA: CO695_04875
PHEI: NCTC12003_03915(rfaP)
PRQ: CYG50_16470(rfaP)
PRJ: NCTC6933_03936(rfaP)
PVC: G3341_19235(rfaP)
PMAG: JI723_19565(rfaP)
PHAG: PZ638_20495(rfaP)
ANS: ArsFIN_07780(rfaP)
AED: E3U36_01250(rfaP)
AET: LDL57_00555(rfaP)
AAPC: QG404_01680(rfaP)
MWI: MNY66_15555(rfaP)
HAV: AT03_01230
HPAR: AL518_04350
OPO: DSM2777_03185
LRI: NCTC12151_00487(rfaP)
PAE: PA5009(waaP)
PAEV: N297_5182(rfaP)
PAEI: N296_5182(rfaP)
PAU: PA14_66220(waaP)
PAP: PSPA7_5744(waaP)
PAG: PLES_53981(waaP)
PAF: PAM18_5123(waaP)
PNC: NCGM2_0506(waaP)
PAEB: NCGM1900_5761(waaP)
PDK: PADK2_26540
PSG: G655_26395
PRP: M062_26405
PAEP: PA1S_27165
PAER: PA1R_gp2934
PAEM: U769_27420
PAEL: T223_27625
PAES: SCV20265_5677
PAEU: BN889_05559(waaP)
PAEG: AI22_06830
PAEC: M802_5180(rfaP)
PAEO: M801_5047(rfaP)
PMY: Pmen_0582
PMK: MDS_0655
PRE: PCA10_52340(waaP)
PPSE: BN5_0471(waaP)
PFUW: KF707C_52580
PALC: A0T30_04710
PCQ: PcP3B5_57620(rfaP)
PMUI: G4G71_05630(rfaP)
PNT: G5B91_29740(rfaP)
PPAA: B7D75_26005
PPU: PP_0344(waaP)
PPF: Pput_0369
PPG: PputGB1_0372
PPW: PputW619_4859
PPT: PPS_0339
PPB: PPUBIRD1_0378(waaP)
PPI: YSA_05705
PPX: T1E_2642(rfaP)
PPUH: B479_02200
PPUT: L483_01755
PPUN: PP4_03740(waaP)
PPUD: DW66_0352
PFV: Psefu_4188
PMON: X969_00020
PMOT: X970_00020
PPJ: RK21_04675
POR: APT59_04280
PMOL: CLJ08_14665
PALD: LU682_001650(rfaP)
PIX: RIN61_13545(rfaP)
PMOS: O165_025650
PST: PSPTO_5000(waaP)
PSB: Psyr_0523
PSYR: N018_23480
PSP: PSPPH_0513(rfaP)
PSAV: PSA3335_24650
PAMG: BKM19_004230
PCI: PCH70_05120
PAVL: BKM03_26275
PVD: CFBP1590__4815(rfaP)
PCAB: JGS08_23865(rfaP)
PCOF: POR16_02305(rfaP)
PTRE: I9H09_21625(rfaP)
PSYI: MME58_02250(rfaP)
PAST: N015_03155(rfaP)
PLIJ: KQP88_02515(rfaP)
PFL: PFL_0514(waaP)
PPRC: PFLCHA0_c05230(rfaP)
PPRO: PPC_0528
PFE: PSF113_0507(waaP)
PFN: HZ99_20430
PFO: Pfl01_0468(rfaP)
PFS: PFLU_0465(rfaP)
PFC: PflA506_0456(waaP)
PPZ: H045_23190
PFB: VO64_3546
PMAN: OU5_2990
PTV: AA957_11750
PCG: AXG94_17645
PVR: PverR02_02390
PAZO: AYR47_09515
POI: BOP93_02170
PRX: HRH33_03250(rfaP)
PKR: AYO71_05100
PMUD: NCTC8068_00472(rfaP)
PTOL: I7845_02390(rfaP)
PFW: PF1751_v1c04390(waaP)
PFF: PFLUOLIPICF705995
PFX: A7318_01210
PEN: PSEEN5140(rfaP)
PLUL: FOB45_21715(rfaP)
PBA: PSEBR_a488
PBC: CD58_02525
PPUU: PputUW4_00400(rfaP)
PDR: H681_22475
PSV: PVLB_23525
PSK: U771_02775
PKC: PKB_5314(rfaP)
PCH: EY04_01890
PCZ: PCL1606_55780
PCP: JM49_27810
PCHP: C4K32_0520
PFZ: AV641_21005
PLQ: AA042_12375
PALK: PSAKL28_03770
PRH: LT40_17975
PSW: LK03_04005
PPV: NJ69_16850
PSES: PSCI_2312
PSEM: TO66_02455
PSEC: CCOS191_4980(rfaP)
PPSY: AOC04_18345
PSOS: POS17_0507
PFK: PFAS1_08805
PANR: A7J50_0454
PPSL: BJP27_18930
PSET: THL1_5272
PSIL: PMA3_01795
PYM: AK972_5449
PADE: C3B55_00200(rfaP)
PKE: DLD99_02645
PALL: UYA_02705
PUM: HGP31_02600(rfaP)
POJ: PtoMrB4_51410(rfaP)
PGG: FX982_01970
PPSH: G5J76_01050(rfaP)
PGY: AWU82_22180
PLAL: FXN65_25645(rfaP)
PSEJ: HNQ25_21445(rfaP)
PVK: EPZ47_02425(rfaP)
PEZ: HWQ56_02490(rfaP)
PBZ: GN234_15610(rfaP)
PKH: JLK41_02805(rfaP)
PTY: JWV26_13735(rfaP)
PMAO: PMYSY11_4070(waaP)
PATA: JWU58_25065(rfaP)
PDW: BV82_1847(rfaP)
PZE: HU754_003450(rfaP)
PMOE: HV782_003275(rfaP)
PCAM: HNE05_15400(rfaP)
PSEP: C4K39_0510
PPII: QL104_02565(rfaP)
PVW: HU752_003360(rfaP)
PTRT: HU722_0003235(rfaP)
PXA: KSS93_05100(rfaP)
PSAM: HU731_018375(rfaP)
PTZ: HU718_003370(rfaP)
PQI: KH389_24945(rfaP)
PSHH: HU773_003035(rfaP)
PXN: HU772_001845(rfaP)
PHV: HU739_015220(rfaP)
PPRG: HU725_001715(rfaP)
PANH: HU763_001585(rfaP)
PASG: KSS96_03285(rfaP)
PFAK: KSS94_01990(rfaP)
PMUY: KSS95_01230(rfaP)
PMAM: KSS90_01875(rfaP)
PAZE: KSS91_02870(rfaP)
PALV: KSS97_03545(rfaP)
PORY: EJA05_01875(rfaP)
PWZ: J7655_02935(rfaP)
PTK: EXN22_25520(rfaP)
PTW: TUM18999_55570(rfaP)
PZA: HU749_003500(rfaP)
PIE: HU724_003240(rfaP)
PTAE: NCTC10697_04122(rfaP_2)
PGF: J0G10_03420(rfaP)
PCAV: D3880_20240(rfaP)
PJU: L1P09_01595(rfaP)
PHF: NLY38_02890(rfaP)
PPHN: HU825_03215(rfaP)
PIZ: LAB08_R04270(rfaP)
PPEG: KUA23_02380(rfaP)
PSII: NF676_03010(rfaP)
PSIH: LOY51_01955(rfaP)
PCAS: LOY40_02650(rfaP)
PFIT: KJY40_03335(rfaP)
PASI: LG197_06850(rfaP)
PKM: PZ739_01765(rfaP)
PNB: NK667_24800(rfaP)
PSOA: PSm6_15180(rfaP)
PTAI: ICN73_04795(rfaP)
PKK: QQ992_01695(rfaP)
PKJ: Q1W70_07965(rfaP)
PHYG: JTY93_02160(rfaP)
PHOM: KJF94_28965(rfaP)
PCHE: QYM18_10550(rfaP)
PCUC: PSH97_02200(rfaP)
PTRL: OU419_25940(rfaP)
PPAE: LDL65_13595(rfaP)
PPAO: K3169_03380(rfaP)
PRHZ: CRX69_01665
PSJY: AA098_25865
PSKU: KUIN1_05340
PSA: PST_3846(waaP)
PSZ: PSTAB_3797
PSR: PSTAA_3940(waaP)
PSC: A458_02230
PSJ: PSJM300_02155
PSH: Psest_0454
PSTT: CH92_19075
PSTU: UIB01_02020
PSED: DM292_00100
PCHL: LLJ08_02190(rfaP)
PBM: CL52_18480
PKG: LW136_02195(rfaP)
SDEG: GOM96_08605(rfaP)
PZD: KQ248_07245(rfaP)
AVN: Avin_44830(waaP)
AVL: AvCA_44830(waaP)
AVD: AvCA6_44830(waaP)
ACX: Achr_6930(waaP)
PBB: AKN87_11310
EMO: DM558_11345(rfaP)
EAZ: JHT90_01520(rfaP)
HPEG: EAO82_17695(rfaP)
HAES: LO767_03005(rfaP)
PDEN: F1C79_21275(rfaP)
HARR: HV822_13675(rfaP)
PNN: KEM63_03680(rfaP)
PPHA: BVH74_08650
DCE: O6P33_04090(rfaP)
PBAU: OS670_10465(rfaP)
PSPI: PS2015_307
CJA: CJA_0503(waaP)
CELL: CBR65_16205
OSG: BST96_07060
HJA: BST95_02475
HALC: EY643_00315(rfaP)
ALG: AQULUS_01080(rfaP)
ASIP: AQUSIP_01040(rfaP)
MOZ: MoryE10_30950(waaP)
MEJ: Q7A_2463
MEC: Q7C_2249
MPIN: LGT42_014330(rfaP)
MMAF: GCM100_11600(rfaP)
MTHA: VSX76_04155(rfaP)
CYQ: Q91_1768(waaP)
CZA: CYCME_0687
CYY: CPC19_03985
AEH: Mlg_2794
TKM: TK90_0318
TBN: TBH_C2798
ABO: ABO_2296(waaP2)
ALN: AS19_23590
ALCA: ASALC70_02808(rfaP)
ADI: B5T_00648(waaP3)
AXE: P40_03015
APAC: S7S_02265
EEI: NX720_08750(rfaP)
ENG: O2T12_20105(rfaP)
EMP: EZMO1_0466(waaP)
GAP: GAPWK_0559
GAQ: RAM11_10560(rfaP)
FPP: FPB0191_00888
GBI: PG2T_13380
PLG: NCTC10937_00694(rfaP_1)
MFA: Mfla_0755
MMB: Mmol_1734
MEI: Msip34_1902
MEP: MPQ_1916
ARES: IWH25_05520(rfaP)
EBA: ebA3995(waaP)
ABRE: pbN1_24480(waaP)
APET: ToN1_30870
AZO: azo3568(waaP1)
AOA: dqs_3711
AZI: AzCIB_0507
AZR: CJ010_21600
TCL: Tchl_1224
TAK: Tharo_3248
ACOM: CEW83_17830
ATW: C0099_12540
APP: CAP2UW1_4194
DDZ: DSYM_19800
SECH: B18_10795
GBZ: JZM60_15845(rfaP)
GSB: GSUB_10380
PCA: Pcar_1275
PACE: A6070_05120
PEF: A7E78_01410
DVE: DESUT3_22640(rfaP)
DOV: DSCO28_11460(waaP)
PARH: I5S86_27120(rfaP)
VBS: EGM51_03960(rfaP)
ACAF: CA12_22700(rfaP)
SVP: Pan189_05190(rfaP)
CHYA: V22_41040(rfaP)
PVAR: SH412_000648
UAM: UABAM_00102
LPRO: PQO03_21185
VBC: C5Q97_19735
 » show all
Reference
1  [PMID:11069912]
  Authors
Yethon JA, Whitfield C.
  Title
Purification and characterization of WaaP from Escherichia coli, a lipopolysaccharide kinase essential for outer membrane stability.
  Journal
J Biol Chem 276:5498-504 (2001)
DOI:10.1074/jbc.M008255200
  Sequence
[eco:b3630]
Reference
2  [PMID:11741974]
  Authors
Zhao X, Lam JS.
  Title
WaaP of Pseudomonas aeruginosa is a novel eukaryotic type protein-tyrosine kinase as well as a sugar kinase essential for the biosynthesis of core lipopolysaccharide.
  Journal
J Biol Chem 277:4722-30 (2002)
DOI:10.1074/jbc.M107803200
  Sequence
[pae:PA5009]
Reference
3  [PMID:30237436]
  Authors
Kreamer NNK, Chopra R, Caughlan RE, Fabbro D, Fang E, Gee P, Hunt I, Li M, Leon BC, Muller L, Vash B, Woods AL, Stams T, Dean CR, Uehara T.
  Title
Acylated-acyl carrier protein stabilizes the Pseudomonas aeruginosa WaaP lipopolysaccharide heptose kinase.
  Journal
Sci Rep 8:14124 (2018)
DOI:10.1038/s41598-018-32379-1
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.235
IUBMB Enzyme Nomenclature: 2.7.1.235
ExPASy - ENZYME nomenclature database: 2.7.1.235
BRENDA, the Enzyme Database: 2.7.1.235

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Chemical substance (4)   
   KEGG COMPOUND (2)   
   KEGG GLYCAN (2)   
Chemical reaction (1)   
   KEGG REACTION (1)   
Gene (2081)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (509)   
   KEGG MGENES (1571)   
Protein sequence (8)   
   UniProt (4)   
   SWISS-PROT (4)   
DNA sequence (4)   
   GenBank (2)   
   EMBL (2)   
Protein domain (2)   
   InterPro (2)   
All databases (2100)   

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