KEGG   ENZYME: 2.7.1.236
Entry
EC 2.7.1.236                Enzyme                                 
Name
NAD+ 3'-kinase;
AvrRxo1
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
Sysname
ATP:NAD+ 3'-phosphotransferase
Reaction(IUBMB)
ATP + NAD+ = ADP + 3'-NADP+ [RN:R12980]
Reaction(KEGG)
R12980
Substrate
ATP [CPD:C00002];
NAD+ [CPD:C00003]
Product
ADP [CPD:C00008];
3'-NADP+ [CPD:C22493]
Comment
The enzyme, best characterized from the plant pathogenic bacterium Xanthomonas oryzae pv. oryzicola, is considered a bacterial type III effector. The product, 3'-NADP, is believed to enhance bacterial virulence on plants through manipulation of primary metabolic pathways. In vitro the enzyme is also active with nicotinate adenine dinucleotide (deamido-NAD).
History
EC 2.7.1.236 created 2022
Orthology
K25765  NAD+ 3'-kinase
Genes
XCVXCV4428(avrRxo1)
XAXXACM_4204
XORXOC_4048(xopAK)
AAVAave_3062
AAAAcav_2220
Reference
1  [PMID:27621317]
  Authors
Schuebel F, Rocker A, Edelmann D, Schessner J, Brieke C, Meinhart A.
  Title
3'-NADP and 3'-NAADP, Two Metabolites Formed by the Bacterial Type III Effector AvrRxo1.
  Journal
J Biol Chem 291:22868-22880 (2016)
DOI:10.1074/jbc.M116.751297
  Sequence
[xor:XOC_4048]
Reference
2  [PMID:28628666]
  Authors
Shidore T, Broeckling CD, Kirkwood JS, Long JJ, Miao J, Zhao B, Leach JE, Triplett LR.
  Title
The effector AvrRxo1 phosphorylates NAD in planta.
  Journal
PLoS Pathog 13:e1006442 (2017)
DOI:10.1371/journal.ppat.1006442
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.236
IUBMB Enzyme Nomenclature: 2.7.1.236
ExPASy - ENZYME nomenclature database: 2.7.1.236
BRENDA, the Enzyme Database: 2.7.1.236

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