KEGG   ENZYME: 2.7.11.28
Entry
EC 2.7.11.28                Enzyme                                 
Name
tropomyosin kinase;
tropomyosin kinase (phosphorylating);
STK (ambiguous)
Class
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases
Sysname
ATP:tropomyosin O-phosphotransferase
Reaction(IUBMB)
ATP + tropomyosin = ADP + O-phosphotropomyosin [RN:R02980]
Reaction(KEGG)
R02980
Substrate
ATP [CPD:C00002];
tropomyosin [CPD:C00839]
Product
ADP [CPD:C00008];
O-phosphotropomyosin [CPD:C03016]
Comment
The enzyme phosphorylates casein equally well, and histone and phosvitin to a lesser extent. The acceptor is a serine residue in the protein.
History
EC 2.7.11.28 created 1990 as EC 2.7.1.132, transferred 2005 to EC 2.7.11.28
Reference
1  [PMID:3593768]
  Authors
deBelle I, Mak AS.
  Title
Isolation and characterization of tropomyosin kinase from chicken embryo.
  Journal
Biochim Biophys Acta 925:17-26 (1987)
DOI:10.1016/0304-4165(87)90143-7
Reference
2  [PMID:6325440]
  Authors
Montgomery K, Mak AS.
  Title
In vitro phosphorylation of tropomyosin by a kinase from chicken embryo.
  Journal
J Biol Chem 259:5555-60 (1984)
Reference
3  [PMID:3166994]
  Authors
Watson MH, Taneja AK, Hodges RS, Mak AS.
  Title
Phosphorylation of alpha alpha- and beta beta-tropomyosin and synthetic peptide analogues.
  Journal
Biochemistry 27:4506-12 (1988)
DOI:10.1021/bi00412a043
Other DBs
ExplorEnz - The Enzyme Database: 2.7.11.28
IUBMB Enzyme Nomenclature: 2.7.11.28
ExPASy - ENZYME nomenclature database: 2.7.11.28
BRENDA, the Enzyme Database: 2.7.11.28
CAS: 90804-56-1

  All links  
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (3)   
   KEGG REACTION (1)   
   KEGG RCLASS (2)   
Protein sequence (1)   
   UniProt (1)   
DNA sequence (2)   
   GenBank (1)   
   EMBL (1)   
All databases (10)   

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