KEGG ENZYME: 2.7.11.29

ENZYME: 2.7.11.29

Entry

EC 2.7.11.29                Enzyme

Name

low-density-lipoprotein receptor kinase;
ATP:low-density-lipoprotein-L-serine O-phosphotransferase;
LDL receptor kinase;
[low-density-lipoprotein] kinase;
low-density lipoprotein kinase;
low-density-lipoprotein receptor kinase (phosphorylating);
STK7

Class

Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases

Sysname

ATP:[low-density-lipoprotein receptor]-L-serine O-phosphotransferase

Reaction(IUBMB)

ATP + [low-density-lipoprotein receptor]-L-serine = ADP + [low-density-lipoprotein receptor]-O-phospho-L-serine

Reaction(KEGG)

(other) R04403

Substrate

ATP [CPD:C00002];
[low-density-lipoprotein receptor]-L-serine

Product

ADP [CPD:C00008];
[low-density-lipoprotein receptor]-O-phospho-L-serine

Comment

Phosphorylates the last serine residue (Ser-833) in the cytoplasmic domain of the low-density lipoprotein receptor from bovine adrenal cortex. Casein can also act as a substrate but with lower affinity. GTP can act instead of ATP.

History

EC 2.7.11.29 created 1990 as EC 2.7.1.131, transferred 2005 to EC 2.7.11.29

Reference

1 [PMID:3100530]

Authors

Kishimoto A, Brown MS, Slaughter CA, Goldstein JL.

Title

Phosphorylation of serine 833 in cytoplasmic domain of low density lipoprotein receptor by a high molecular weight enzyme resembling casein kinase II.

Journal

J Biol Chem 262:1344-51 (1987)

Reference

2 [PMID:3597414]

Authors

Kishimoto A, Goldstein JL, Brown MS.

Title

Purification of catalytic subunit of low density lipoprotein receptor kinase and identification of heat-stable activator protein.

Journal

J Biol Chem 262:9367-73 (1987)

Other DBs

ExplorEnz - The Enzyme Database:

2.7.11.29

IUBMB Enzyme Nomenclature:

2.7.11.29

ExPASy - ENZYME nomenclature database:

2.7.11.29

BRENDA, the Enzyme Database:

2.7.11.29

CAS:	107445-00-1

All links

Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (3)   
   KEGG REACTION (1)   
   KEGG RCLASS (2)   
All databases (7)   

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