KEGG ENZYME: 2.7.11.36

ENZYME: 2.7.11.36

Entry

EC 2.7.11.36                Enzyme

Name

MASTL-subfamily protein kinase;
MASTL;
gwl;
greatwall kinase;
RIM15;
microtubule-associated (MASTL)-subfamily-protein kinase

Class

Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases

Sysname

ATP:[endosulfine family protein] phosphotransferase (Ser/Thr-phosphorylating)

Reaction(IUBMB)

(1) ATP + [endosulfine family protein]-L-serine = ADP + [endosulfine family protein]-O-phospho-L-serine;
(2) ATP + [endosulfine family protein]-L-threonine = ADP + [endosulfine family protein]-O-phospho-L-threonine

Substrate

ATP [CPD:C00002];
[endosulfine family protein]-L-serine;
[endosulfine family protein]-L-threonine

Product

ADP [CPD:C00008];
[endosulfine family protein]-O-phospho-L-serine;
[endosulfine family protein]-O-phospho-L-threonine

Comment

Requires Mg2+. Peptide array data suggest that MASTL prefers to phosphorylate Ser over Thr, followed at position +1 by a bulky hydrophobic (Met, Leu, Phe or Tyr) and with an aromatic residue in the -2 position [4]. Its main role in animal systems is in the regulation of mitosis by phosphorylating a conserved site on endosulfine family proteins (ENSA and ARPP-19 in human), causing them to inhibit the protein phosphatase 2A-B55 [protein phosphatase 2A (PP2A) holoenzyme complex containing a B55-family regulatory subunit] [2].

History

EC 2.7.11.36 created 2024

Orthology

K12767

serine/threonine-protein kinase RIM15

K16309

serine/threonine-protein kinase greatwall

Genes

HSA:	84930(MASTL)

PTR:	450367(MASTL)

PPS:	100969069(MASTL)

GGO:	101147876(MASTL)

PON:	100441835(MASTL)

NLE:	100602092(MASTL)

HMH:	116462286(MASTL)

MCC:	708134(MASTL)

MCF:	102139449(MASTL)

MTHB:

126962867

MNI:	105479991(MASTL)

CSAB:

103238037(MASTL)

CATY:

105583764(MASTL)

PANU:

101010870(MASTL)

TGE:	112631604(MASTL)

MLEU:

105533879(MASTL)

RRO:	104676580(MASTL)

RBB:	108515840(MASTL)

TFN:	117082213(MASTL)

PTEH:

111528030(MASTL)

CANG:

105516888(MASTL)

CJC:	100411791(MASTL)

SBQ:	101027670(MASTL)

CIMI:

108309261(MASTL)

CSYR:

103266929(MASTL)

MMUR:

105878110(MASTL)

LCAT:

123625082(MASTL)

PCOQ:

105818756(MASTL)

OGA:	100957407(MASTL)

MMU:	67121(Mastl)

MCAL:

110289331(Mastl)

MPAH:

110318334(Mastl)

RNO:	307169(Mastl)

MCOC:

116089770(Mastl)

ANU:	117699793 117713454(Mastl)

MUN:	110559248(Mastl)

CGE:	100770735(Mastl)

MAUA:

101832930(Mastl)

PROB:

127237431(Mastl)

MORG:

121440760(Mastl)

AAMP:

119816583(Mastl)

NGI:	103733003(Mastl)

HGL:	101723064(Mastl)

CPOC:

100717057(Mastl) 100727887

CCAN:

109681845(Mastl)

DORD:

105984416(Mastl)

DSP:	122113118(Mastl)

PLOP:

125367273(Mastl)

NCAR:

124961036

MMMA:

107150297(Mastl)

OCU:

100352184

OPI:	101520671(MASTL)

TUP:	102485785(MASTL)

GVR:	103595931(MASTL)

CFA:	607216(MASTL)

CLUD:

112670285(MASTL)

VVP:	112931100(MASTL)

VLG:	121496890(MASTL)

NPO:	129513267(MASTL)

AML:	100464443(MASTL)

UMR:	103680136(MASTL)

UAH:	113248682(MASTL)

UAR:	123778152(MASTL)

ELK:

111139705

LLV:	125106826 125107141 125107625

MPUF:

101678682(MASTL)

MNP:	132020073(MASTL)

MLK:	131838134(MASTL)

NVS:	122891743(MASTL)

EJU:	114203616 114203732 114225859

ZCA:	113912214 118355977

MLX:	118026854(MASTL)

NSU:	110577730(MASTL)

LWW:	102726141(MASTL)

FCA:	101083601(MASTL)

PYU:	121014686(MASTL)

PCOO:

112867575(MASTL)

PBG:	122474072(MASTL)

PVIV:

125171133(MASTL)

LRUF:

124501355

PTG:	102959854(MASTL)

PPAD:

109276359(MASTL)

PUC:

125918660

AJU:

106973558

HHV:	120222615(MASTL)

BTA:	540206(MASTL)

BOM:	102283244(MASTL)

BIU:	109567982(MASTL)

BBUB:

102389680(MASTL)

BBIS:

105002971(MASTL)

CHX:	102176245(MASTL)

OAS:	101119067(MASTL)

BTAX:

128058893(MASTL)

ODA:	120869253(MASTL)

CCAD:

122448531(MASTL)

MBEZ:

129557160(MASTL)

SSC:	100514867(MASTL)

CFR:	102506776(MASTL)

CBAI:

105079222(MASTL)

CDK:	105102336(MASTL)

VPC:	102538931(MASTL)

BACU:

103010523(MASTL)

BMUS:

118890294(MASTL)

LVE:	103068340(MASTL)

OOR:	101274125(MASTL)

DLE:	111178016(MASTL)

PCAD:

102982150(MASTL)

PSIU:

116750002(MASTL)

NASI:

112392448(MASTL)

ECB:	100055294(MASTL)

EPZ:	103560859(MASTL)

EAI:	106848389(MASTL)

MYB:	102251056(MASTL)

MYD:	102754266(MASTL)

MMYO:

118673644(MASTL)

MLF:	102419642(MASTL)

PKL:	118730772(MASTL)

EFUS:

103304277(MASTL)

MNA:	107542182(MASTL)

DRO:	112319354(MASTL)

SHON:

118980556(MASTL)

AJM:

119040902

PDIC:

114492989(MASTL)

PHAS:

123831190(MASTL)

MMF:	118629671(MASTL)

PPAM:

129084208(MASTL)

HAI:	109377669(MASTL)

RFQ:	117019239(MASTL)

PALE:

102890046(MASTL)

PGIG:

120614696(MASTL)

PVP:	105299326(MASTL)

RAY:	107503342(MASTL)

MJV:	108387295(MASTL)

TOD:

119244773

SARA:

101559389(MASTL)

SETR:

126014461(MASTL)

LAV:	100664255(MASTL)

TMU:

101340565

ETF:	101654884(MASTL)

DNM:	101439232(MASTL)

MDO:	100024914(MASTL)

GAS:	123249332(MASTL)

SHR:	100922838(MASTL)

AFZ:

127539043

PCW:	110211156(MASTL)

OAA:	100075457(MASTL)

GGA:	420487(MASTL)

PCOC:

116243344(MASTL)

MGP:	100541707(MASTL)

CJO:	107308947(MASTL)

TPAI:

128086171(MASTL)

LMUT:

125695871(MASTL)

NMEL:

110394960(MASTL)

APLA:

101799804(MASTL)

ACYG:

106042679(MASTL)

CATA:

118247379(MASTL)

AFUL:

116486895(MASTL)

TGU:	100222917(MASTL)

LSR:	110477332(MASTL)

SCAN:

103813087(MASTL)

PMOA:

120500502(MASTL)

OTC:	121338081(MASTL)

PRUF:

121364790(MASTL)

GFR:	102037948(MASTL)

FAB:	101811825(MASTL)

OMA:	130250247(MASTL)

PHI:	102103846(MASTL)

PMAJ:

107200091(MASTL)

CCAE:

111924113(MASTL)

CCW:	104689362(MASTL)

CBRC:

103620658(MASTL)

ETL:	114060314(MASTL)

ZAB:	102074871(MASTL)

ACHL:

103811230(MASTL)

SVG:	106856655(MASTL)

MMEA:

130584327(MASTL)

HRT:	120762046(MASTL)

FPG:	101915317(MASTL)

FCH:	102057418(MASTL)

CLV:	102086324(MASTL)

EGZ:	104122429(MASTL)

NNI:	104016229(MASTL)

PCRI:

104028629(MASTL)

PLET:

104613660(MASTL)

EHS:	104502585(MASTL)

PCAO:

104049075(MASTL)

ACUN:

113477196(MASTL)

TALA:

104360086(MASTL)

PADL:

103921206(MASTL)

AFOR:

103895600(MASTL)

ACHC:

115339461(MASTL)

HALD:

104311463(MASTL)

HLE:	104828888(MASTL)

AGEN:

126037711

GCL:

127013539

CCRI:

104155309(MASTL)

CSTI:

104549514(MASTL)

CMAC:

104477264(MASTL)

MUI:	104533686(MASTL)

BREG:

104643544(MASTL)

FGA:	104069349(MASTL)

GSTE:

104250776(MASTL)

LDI:	104340066(MASTL)

MNB:	103768803(MASTL)

OHA:	104339033(MASTL)

NNT:	104403313(MASTL)

SHAB:

115611019(MASTL)

DPUB:

104298526(MASTL)

PGUU:

104462821(MASTL)

ACAR:

104527922(MASTL)

CPEA:

104397096(MASTL)

AVIT:

104267126(MASTL)

CVF:	104291356(MASTL)

RTD:	128905973(MASTL)

CUCA:

104066681(MASTL)

TEO:	104374601(MASTL)

BRHI:

104491774(MASTL)

AAM:	106489988(MASTL)

AROW:

112974820(MASTL)

NPD:	112955462(MASTL)

TGT:	104580405(MASTL)

DNE:	112984039(MASTL)

SCAM:

104147167(MASTL)

ASN:	102384690(MASTL)

AMJ:	102574097(MASTL)

CPOO:

109307576(MASTL)

GGN:	109291301(MASTL)

PSS:	102445474(MASTL)

CMY:	102941097(MASTL)

CCAY:

125631328(MASTL)

DCC:	119850496(MASTL)

CPIC:

101934395(MASTL)

TST:	117872107(MASTL)

CABI:

116828161(MASTL)

MRV:	120396845(MASTL)

ACS:	100565049(mastl)

ASAO:

132778923(MASTL)

PVT:	110083086(MASTL)

SUND:

121933112

PBI:	103061556(MASTL)

PMUR:

107282820(MASTL)

CTIG:

120314516(MASTL)

TSR:	106538640(MASTL)

PGUT:

117654902(MASTL)

APRI:

131197060(MASTL)

PTEX:

113442449(MASTL)

NSS:	113414995(MASTL)

VKO:	123020818(MASTL)

PMUA:

114607572(MASTL)

PRAF:

128398506(MASTL)

ZVI:	118091705(MASTL)

HCG:	128330130(MASTL)

GJA:	107113048(MASTL)

STOW:

125441370(MASTL)

EMC:	129337403(MASTL)

XLA:	108719853 414585(mastl.L)

XTR:	100145700(mastl)

NPR:	108796104(MASTL)

RTEM:

120940027(MASTL)

BBUF:

121002811(MASTL)

BGAR:

122938252(MASTL)

MUO:	115468822(MASTL)

GSH:	117354253(MASTL)

DRE:	445215(mastl)

SRX:	107739118(mastl) 107758386

SANH:

107675144 107687524

SGH:	107566299(mastl) 107588092

CCAR:

109110659

CAUA:

113042145 113065986

CGIB:

127946431 128013188

PTET:

122329416(mastl)

LROH:

127156108(mastl)

OMC:	131533601(mastl)

PPRM:

120475779(mastl)

RKG:	130084447(mastl)

MAMB:

125258057(mastl)

CIDE:

127506413

MASI:

127432021 127434670

TROS:

130547249(mastl)

TDW:	130412822(mastl)

MANU:

129425524(mastl)

IPU:

108272793

IFU:	128615026(mastl)

PHYP:

113545391(mastl)

SMEO:

124384966(mastl)

TFD:	113651144(mastl)

TVC:	132845522(mastl)

TRN:	134310429(mastl)

AMEX:

103045715(mastl)

CMAO:

118815730(mastl)

EEE:	113582136(mastl)

CHAR:

105889234(mastl)

TRU:	101079068(mastl)

TFS:	130514164(mastl)

LCO:	104937076(mastl)

NCC:	104942380(mastl)

TBEN:

117494571(mastl)

CGOB:

115025432(mastl)

PGEO:

117465489(mastl)

GACU:

117544740(mastl)

EMAC:

134858085(mastl)

ELY:	117264777(mastl)

EFO:	125881747(mastl)

PLEP:

121960608(mastl)

SLUC:

116048573(mastl)

ECRA:

117938045(mastl)

ESP:	116672449(mastl)

PFLV:

114549074(mastl)

GAT:	120811462(mastl)

PPUG:

119198586(mastl)

AFB:	129110600(mastl)

CLUM:

117749389(mastl)

PSWI:

130206117(mastl)

MSAM:

119912209(mastl)

SCHU:

122866222(mastl)

CUD:	121527208(mastl)

ALAT:

119008489(mastl)

MZE:	101474211(mastl)

ONL:	100712169(mastl)

OAU:	116310343(mastl)

OLA:	101170130(mastl)

OML:	112151391(mastl)

CSAI:

133423518(mastl)

XMA:	102229766(mastl)

XCO:	114137242(mastl)

XHE:	116712382(mastl)

PRET:

103456784(mastl)

PFOR:

103140563(mastl)

PLAI:

106951256(mastl)

PMEI:

106923952(mastl)

GAF:	122823975(mastl)

PPRL:

129352085(mastl)

CVG:	107104720(mastl)

CTUL:

119798428(mastl)

GMU:	124857630(mastl)

NFU:	107383036(mastl)

KMR:	108230294(mastl)

ALIM:

106515559(mastl)

NWH:	119426284(mastl)

AOCE:

111570854(mastl)

MCEP:

124995776(mastl)

CSEM:

103377356(mastl)

POV:	109639633(mastl)

SSEN:

122785054(mastl)

HHIP:

117754182(mastl)

HSP:	118098556(mastl)

PPLT:

128425725(mastl)

SMAU:

118290906(mastl)

LCF:

108900021

SDU:	111224328(mastl)

SLAL:

111673641(mastl)

XGL:	120789535(mastl)

HCQ:	109527551(mastl)

SSCV:

125985866

SBIA:

133492679(mastl)

PEE:	133396280(mastl)

PTAO:

133470032(mastl)

BPEC:

110170004(mastl)

MALB:

109961422(mastl)

BSPL:

114853700(mastl)

SJO:	128382445(mastl)

SASA:

106579700 106590301

STRU:

115149233 115195661

OTW:	112227859(mastl) 112235099

OMY:	110489821(mastl) 110535193

OGO:	123990300 124039690

ONE:	115124529 115130269(mastl)

OKI:	109899386 109909759

OKE:	118371998(mastl)

SALP:

111953141(mastl)

SNH:

120051077

CCLU:

121549733 121569409

ELS:	105030064(mastl)

SFM:	108927643(mastl)

PKI:	111850026(mastl)

AANG:

118226511(mastl)

LOC:	102684143(mastl)

PSPA:

121314115(mastl)

ARUT:

117399932 117435241

PSEX:

120529771(mastl)

LCM:	102352243(MASTL)

CMK:	103183594(mastl)

RTP:	109931983(mastl)

CPLA:

122550059(mastl)

HOC:	132815798(mastl)

LERI:

129707188(mastl)

PMRN:

116947538(MASTL)

LRJ:	133345101(MASTL)

BFO:

118403878

BBEL:

109483955

CIN:

100176473

SCLV:

120345967

SPU:	100889839 115927240

LPIC:

129263193

APLC:

110982383

AJC:

117117695

DME:	Dmel_CG7719(gwl)

DER:

6553862

DSE:

6613721

DSI:	Dsimw501_GD19248(Dsim_GD19248)

DYA:	Dyak_GE25560

DAN:

6505859

DSR:

110186948

DPO:

4801974

DPE:

6588426

DMN:

108154636

DWI:

6649862

DGR:

6568423

DMO:	Dmoj_GI22962

DAZ:

108621808

DNV:

108659185

DHE:

111604251

DVI:

6635013

CCAT:

101451216

BOD:

106617640

BDR:

105231019

RZE:

108369195

AOQ:

129239280

TDA:	119673928 119683324

MDE:

101889602

SCAC:

106095799

LCQ:

111683470

LSQ:

119600975

GFS:

119638194

ECOE:

129942763

CLON:

129614609

HIS:

119651621

AGA:

3290493

ACOZ:

120949924

AARA:

120896554

AMER:

121590204

ASTE:

118505177

AFUN:

125774838

AMOU:

128310306

AALI:

118457933

AAG:

5580179

AALB:

109425329

CQU:	CpipJ_CPIJ002365

CPII:

120428910

CNS:

116342497

BCOO:

119067879

AME:

411080

ACER:

107997665

ALAB:

122714925

ADR:

102679445

AFLR:

100871506

BIM:

100742142

BBIF:

117205376

BVK:

117237176

BVAN:

117161917

BTER:

100645119

BAFF:

126922094

BPYO:

122567403

BPAS:

132912586

FVI:

122537546

CCAL:

108624814

OBB:

114877713

OLG:

117602980

MGEN:

117227646 117227648

NMEA:

116426661

CGIG:

122398796

SOC:

105202774

MPHA:

105833533

AEC:

105153910

ACEP:

105618092

PBAR:

105423595

VEM:

105564611

HST:

105181615

DQU:

106747415

CFO:

105255213

FEX:

115241351

LHU:

105672910

PGC:

109852842

OBO:

105280619

PCF:

106789651

PFUC:

122516979

VPS:

122631264

VCRB:

124426278

VVE:

124951685

NVI:

100117041

CSOL:

105366043

TPRE:

106660567

LHT:

122498890

LBD:

127280504

MDL:

103580553

CGLO:

123267480

FAS:

105274232

DAM:

107048150

AGIF:

122860554

CINS:

118070113

VCAN:

122412211

CCIN:

107263277

DSM:

124413647

NPT:

124217779

NFB:

124187301

NLO:

107217085

NVG:

124299605

AROA:

105692699

DPA:

109541779

SOY:

115889655

AGRG:

126739405

ATD:

109598738

CSET:

123313759

AGB:

108907405

LDC:

111505904

DVV:

126884630

NVL:

108562652

PPYR:

116173666

OTU:

111413394

BMOR:

101741312

BMAN:

114249067

MSEX:

115448355

DPL:	KGM_203829

BANY:

112051303

MJU:

123878008

NIQ:

126771765

VCD:

124533659

MCIX:

123669391

PMAC:

106708960

PPOT:

106100697

PXU:

106124608

PRAP:

110994918

PBX:

123716212

PNAP:

125063685

ZCE:

119829279

CCRC:

123706485

LSIN:

126966315

AAGE:

121730464

HAW:	110374107(gwl)

HZE:

124632253

TNL:	113496377 113496420

SLIU:

111353261

OFU:

114349740

PXY:

105385931

PGW:

126375151

CFEL:

113365717 113367804

CCRN:

123302620

API:

100163462

DNX:

107168643

AGS:

114126152

RMD:

113548194

ACOO:

126846735

DVT:	126894235 126909611

BTAB:

109043176

DCI:

103507038

CLEC:

106663125

HHAL:

106689571

NLU:

111046742

HVI:

124354710

MQU:	128996237 129005724

PHU:	Phum_PHUM380500

FOC:

113217842

TPAL:

117642792

ZNE:

110830574

CSEC:

111871057

SGRE:

126268070 126319917

BROR:

134530241

IEL:

124157520

DPX:	DAPPUDRAFT_328306

DMK:

116932343

DPZ:

124351149

PVM:

113802435

PJA:

122254787

PCHN:

125042573

PMOO:

119589924

HAME:

121867245

PCLA:

123746512

CQD:

128702424

PTRU:

123503725

ESN:

127006130

HAZT:

108669828

EAF:

111696892

LSM:

121115778

TCF:

131879825

PPOI:

119089793

ISC:

8024491

DSV:

119441305

RSAN:

119386540

RMP:

119178200

VDE:

111248070

VJA:

111261324

CSCU:

111622816

PTEP:

107447836

ABRU:

129961861

UDV:

129217300

SDM:

118192312

LPOL:

106473123

LGI:	LOTGIDRAFT_115088

PVUL:

126824917

PCAN:

112558639

BGT:

106079640

GAE:

121382066

HRF:

124116831

HRJ:

124267713

CRG:

105321199

CVN:	111116615 111117050

CANU:

128190837

OED:

125683560

MYI:

110446979

PMAX:

117336098

MCAF:

127706655

MMER:

123536014

RPHI:

132750972

OBI:

106867829

OSN:

115212233

LAK:

106174668

NVE:

5510048

EPA:

110252690

ATEN:

116300539

ADF:

107353685

AMIL:

114960450

PDAM:

113680615

SPIS:

111336712

DGT:

114518139

XEN:

124453469

HMG:

100199468

HSY:	130612600 130613210

TAD:	TRIADDRAFT_7368

CME:	CYME_CML232C

SCE:	YFL033C(RIM15)

SEUB:

DI49_1623

SPAO:

SPAR_F00310

AGO:	AGOS_ACR218W

ERC:

Ecym_1508

KMX:	KLMA_20301(RIM15)

LTH:	KLTH0G18612g

ZRO:	ZYRO0F03014g

CGR:	CAGL0K12562g

NCS:	NCAS_0C03770(NCAS0C03770)

NDI:	NDAI_0G03110(NDAI0G03110)

TPF:	TPHA_0D00360(TPHA0D00360)

TBL:	TBLA_0G03450(TBLA0G03450)

TGB:	HG536_0B06680

TDL:	TDEL_0C00590(TDEL0C00590)

KAF:	KAFR_0C03520(KAFR0C03520)

KNG:	KNAG_0E03200(KNAG0E03200)

ZMK:	HG535_0D05830

PPA:	PAS_chr3_0148

DHA:	DEHA2F22572g

PIC:	PICST_88182

PGU:	PGUG_00398

SPAA:

SPAPADRAFT_144352

LEL:	PVL30_005196(RIM15)

CAL:	CAALFM_C700740WA(RIM15)

CTP:	CTRG_05071

COT:	CORT_0G02440

CDU:	CD36_70680

CTEN:

CANTEDRAFT_132921

YLI:	YALI0F14707g

CLU:	CLUG_04432

CLUS:

A9F13_04g00715

CAUR:

CJI96_0001818

SLB:	AWJ20_3765(RIM15)

PKZ:	C5L36_0B10390

BNN:	FOA43_001033

BBRX:

BRETT_003669

OPA:	HPODL_04619

SLUD:

SCDLUD_000650

NCR:	NCU07378(stk-12)

NTE:	NEUTE1DRAFT90387(NEUTE1DRAFT_90387)

SMP:	SMAC_00327(putative_rim15)

PAN:	PODANSg4278

PBEL:

QC761_117910(RIM15)

PPSD:

QC762_117910(RIM15)

PPSP:

QC763_117910(RIM15)

PPSA:

QC764_117910(RIM15)

TTT:	THITE_2112540

MTM:	MYCTH_2297068

CTHR:

CTHT_0003620

MGR:

MGG_00345

PPEI:

PpBr36_08805

PGRI:

PgNI_08999

TMN:	UCRPA7_4043

SSCK:

SPSK_00001

FGR:	FGSG_01312

FPU:	FPSE_03348

FPOA:

FPOAC1_001409

FVN:	FVRRES_01611

FVR:	FVEG_01441

FOX:	FOXG_00074

NHE:	NECHADRAFT_65406

FFC:	NCS54_00054300

FKR:	NCS57_00052500

FMU:	J7337_000584

TRE:	TRIREDRAFT_120605

TRR:	M419DRAFT_35563

MAW:

MAC_07146

MAJ:

MAA_00194

PCHM:

VFPPC_05526

CMT:

CCM_01126

AMUS:

LMH87_011627

PLJ:	VFPFJ_03277

PTKZ:

JDV02_001765(RIM15)

VAL:	VDBG_06063

VDA:	VDAG_03223

CFJ:	CFIO01_11128

CLUP:

CLUP02_12395

CHIG:

CH63R_11759

SAPO:

SAPIO_CDS3067

PFY:	PFICI_01434

SSL:	SS1G_08085

BFU:	BCIN_15g00280

MBE:

MBM_00156

PSCO:

LY89DRAFT_236313

GLZ:	GLAREA_06752

ANI:	ANIA_07572

AFM:	AFUA_2G15010

ACT:	ACLA_072470

NFI:	NFIA_090250

AOR:	AO090012000420

ANG:	An15g03140

AFV:	AFLA_002138

ALUC:

AKAW2_60399A(RIM15)

ACHE:

ACHE_31354A(RIM15)

APUU:

APUU_80381S(RIM15)

PCS:	N7525_002435

PDP:	PDIP_04910

POU:	POX_h09852

TMF:	EYB26_006437

TRG:	TRUGW13939_02397

CIM:	CIMG_02369

CPW:	CPC735_040100

URE:	UREG_01387

PBL:	PAAG_11342(PAAG_01699)

PBN:	PADG_00079

ABE:

ARB_03641

TVE:

TRV_01962

AJE:	HCAG_00258

BGH:	BDBG_00069

PNO:	SNOG_04203

PTE:

PTT_10846

BZE:	COCCADRAFT_10040

BSC:	COCSADRAFT_92353

BOR:	COCMIDRAFT_7043

AALT:

CC77DRAFT_675843

ARAB:

EKO05_0001881

ZTR:	MYCGRDRAFT_66207

PFJ:	MYCFIDRAFT_212900

FFU:	CLAFUR5_00589

CBET:

CB0940_00448

BCOM:

BAUCODRAFT_246511

TML:	GSTUM_00011380001

SPO:	SPAPB18E9.02c(ppk18) SPCC1450.11c(cek1)

SOM:	SOMG_02972(cek1) SOMG_04643(ppk18)

CNE:

CNC00600

CNB:

CNBC6630

CNG:	CNAG_03024

CGI:	CGB_C9140C

CDEU:

CNBG_3665

TMS:	TREMEDRAFT_25150

TASA:

A1Q1_06061

CCAC:

CcaHIS019_0705050(RIM15)

PPL:	POSPLDRAFT_107196

TVS:	TRAVEDRAFT_117940

DSQ:	DICSQDRAFT_155239

PCO:	PHACADRAFT_136458

SHS:	STEHIDRAFT_120647

HIR:	HETIRDRAFT_62517

PSQ:	PUNSTDRAFT_50963

ADL:	AURDEDRAFT_110472

FME:	FOMMEDRAFT_147936

GTR:	GLOTRDRAFT_114103

RSX:	RhiXN_03908

LBC:	LACBIDRAFT_311677

CCI:	CC1G_14606

ABP:	AGABI1DRAFT128068(Rim15)

ABV:	AGABI2DRAFT116951(RIM15)

PCUB:

JR316_0004900

MRR:	Moror_8065

E1B28_004194

SCM:	SCHCO_02621581(SCHCODRAFT_02621581)

CPUT:

CONPUDRAFT_81831

SLA:	SERLADRAFT_367409(RIM15)

WSE:	WALSEDRAFT_48096

WIC:	J056_003616

UMA:	UMAG_11677

PFP:	PFL1_05914

SGRA:

EX895_004280

MGL:

MGL_0215

MRT:

MRET_1100

PGR:	PGTG_21795

PTRC:

PtA15_16A295

PSTR:

Pst134EA_029239

MLR:	MELLADRAFT_91398

MBR:	MONBRDRAFT_8114

DDI:	DDB_G0276157(pkgA)

DPP:	DICPUDRAFT_159783

DFA:	DFA_04541(pkgA)

» show all

Reference

1 [PMID:20027184]

Authors

Pearce LR, Komander D, Alessi DR

Title

The nuts and bolts of AGC protein kinases.

Journal

Nat Rev Mol Cell Biol 11:9-22 (2010)
DOI:10.1038/nrm2822

Sequence

[hsa:84930]

Reference

2 [PMID:30355803]

Authors

Castro A, Lorca T.

Title

Greatwall kinase at a glance.

Journal

J Cell Sci 131:jcs222364 (2018)
DOI:10.1242/jcs.222364

Reference

3 [PMID:33266510]

Authors

Goguet-Rubio P, Amin P, Awal S, Vigneron S, Charrasse S, Mechali F, Labbe JC, Lorca T, Castro A.

Title

PP2A-B55 Holoenzyme Regulation and Cancer.

Journal

Biomolecules 10:biom10111586 (2020)
DOI:10.3390/biom10111586

Reference

4 [PMID:36631611]

Authors

Johnson JL, Yaron TM, Huntsman EM, Kerelsky A, Song J, Regev A, Lin TY, Liberatore K, Cizin DM, Cohen BM, Vasan N, Ma Y, Krismer K, Robles JT, van de Kooij B, van Vlimmeren AE, Andree-Busch N, Kaufer NF, Dorovkov MV, Ryazanov AG, Takagi Y, Kastenhuber ER, Goncalves MD, Hopkins BD, Elemento O, Taatjes DJ, Maucuer A, Yamashita A, Degterev A, Uduman M, Lu J, Landry SD, Zhang B, Cossentino I, Linding R, Blenis J, Hornbeck PV, Turk BE, Yaffe MB, Cantley LC.

Title

An atlas of substrate specificities for the human serine/threonine kinome.

Journal

Nature 613:759-766 (2023)
DOI:10.1038/s41586-022-05575-3

Other DBs

ExplorEnz - The Enzyme Database:

2.7.11.36

IUBMB Enzyme Nomenclature:

2.7.11.36

ExPASy - ENZYME nomenclature database:

2.7.11.36

BRENDA, the Enzyme Database:

2.7.11.36

All links

Gene (822)   
   KEGG ORTHOLOGY (2)   
   KEGG GENES (820)   
All databases (822)   

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