Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with a carboxy group as acceptor
BRITE hierarchy

ATP:fatty acid 1-phosphotransferase

ATP + a fatty acid = ADP + a fatty acyl phosphate (overall reaction) [RN:R12793];
(1a) ATP + a fatty acid-[fatty acid-binding protein] = ADP + a fatty acyl phosphate-[fatty acid-binding protein];
(1b) a fatty acyl phosphate-[fatty acid-binding protein] + a fatty acid = a fatty acyl phosphate + a fatty acid-[fatty acid-binding protein]

R12793
Reaction

ATP [CPD:C00002];
fatty acid [CPD:C00162];
fatty acid-[fatty acid-binding protein];
fatty acyl phosphate-[fatty acid-binding protein]

The enzyme is a dimeric complex consisting of an ATP-binding protein (FakA) and a fatty acid-binding protein (FakB). The first step in the reaction is the binding of FakB (with a bound fatty acid) to FakA. The fatty acid bound to FakB is then phosphorylated by FakA, and the fatty acyl phosphate-bound FakB is released from the complex. In the presence of an exchangeable fatty acid pool in the cell membrane, the fatty acy phosphate bound to FakB exchanges with a fatty acid to regenerate the substrate for FakA. The system is widespread in Gram-positive bacteria, with most strains possessing a single FakA protein along with multiple FakB subunits that differ in their specificity towards fatty acid substrates.

EC 2.7.2.18 created 2021