KEGG   ENZYME: 2.7.4.29
Entry
EC 2.7.4.29                 Enzyme                                 
Name
Kdo2-lipid A phosphotransferase;
lipid A undecaprenyl phosphotransferase;
LpxT;
YeiU
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with a phosphate group as acceptor
Sysname
ditrans-octacis-undecaprenyl-diphosphate:alpha-D-Kdo-(2->4)-alpha-D-Kdo-(2->6)-lipid-A phosphotransferase
Reaction(IUBMB)
ditrans-octacis-undecaprenyl diphosphate + alpha-D-Kdo-(2->4)-alpha-D-Kdo-(2->6)-lipid A = ditrans-octacis-undecaprenyl phosphate + alpha-D-Kdo-(2->4)-alpha-D-Kdo-(2->6)-lipid A 1-diphosphate [RN:R11186]
Reaction(KEGG)
R11186
Substrate
ditrans,octacis-undecaprenyl diphosphate [CPD:C04574];
alpha-D-Kdo-(2->4)-alpha-D-Kdo-(2->6)-lipid A [CPD:C06026]
Product
ditrans,octacis-undecaprenyl phosphate [CPD:C17556];
alpha-D-Kdo-(2->4)-alpha-D-Kdo-(2->6)-lipid A 1-diphosphate [CPD:C21157]
Comment
An inner-membrane protein. The activity of the enzyme is regulated by PmrA. In vitro the enzyme can use diacylglycerol 3-diphosphate as the phosphate donor.
History
EC 2.7.4.29 created 2015
Pathway
ec00540  Lipopolysaccharide biosynthesis
Orthology
K19803  Kdo2-lipid A phosphotransferase
Genes
ECO: b2174(lpxT)
ECJ: JW2162(yeiU)
ECD: ECDH10B_2332(yeiU)
EBW: BWG_1950(lpxT)
ECOK: ECMDS42_1744(yeiU)
ECOC: C3026_12165
ECE: Z3433
ECS: ECs_3066(lpxT)
ECF: ECH74115_3312
ETW: ECSP_3054(yeiU)
ELX: CDCO157_2829
EOI: ECO111_2893(yeiU)
EOJ: ECO26_3087(yeiU)
EOH: ECO103_2651(yeiU)
ECOO: ECRM13514_2938
ECOH: ECRM13516_2879
ESL: O3K_08570
ESO: O3O_17065
ESM: O3M_08520
ECK: EC55989_2428(yeiU)
ECG: E2348C_2321(yeiU)
EOK: G2583_2717(yeiU)
ELR: ECO55CA74_13440
ELH: ETEC_2311
ECW: EcE24377A_2472
EUN: UMNK88_2722
ECP: ECP_2215
ENA: ECNA114_2268
ECOS: EC958_2512
ECV: APECO1_4380(yeiU)
ECOA: APECO78_14595
ECX: EcHS_A2312
ECM: EcSMS35_2323
ECY: ECSE_2443
ECR: ECIAI1_2256(yeiU)
ECQ: ECED1_2624(yeiU)
EUM: ECUMN_2511(yeiU)
ECT: ECIAI39_2315(yeiU)
EOC: CE10_2548(lpxT)
EBR: ECB_02104(yeiU)
ECOB: C3029_15060
EBL: ECD_02104(lpxT)
EBE: B21_02063(lpxT)
EBD: ECBD_1483
ECI: UTI89_C2451
EIH: ECOK1_2409
ECZ: ECS88_2323(yeiU)
ECC: c2711(yeiU)
ELO: EC042_2407
ELN: NRG857_11040
ESE: ECSF_2056
ECL: EcolC_1473
EKO: EKO11_1579
EKF: KO11_11755(lpxT)
EAB: ECABU_c25060(yeiU)
EDH: EcDH1_1483
EDJ: ECDH1ME8569_2111(yeiU)
ELU: UM146_05920
ELW: ECW_m2376(lpxT)
ELL: WFL_11625(lpxT)
ELC: i14_2511(yeiU)
ELD: i02_2511(yeiU)
ELP: P12B_c2270
ELF: LF82_3022(yeiU)
ECOL: LY180_11365
ECOI: ECOPMV1_02335(yeiU)
ECOJ: P423_12225
EFE: EFER_2263(yeiU)
EAL: EAKF1_ch3816c
EMA: C1192_01025
ESZ: FEM44_01105(lpxT)
ERUY: OSH18_20410(lpxT)
STY: STY2449
STT: t0642
SEX: STBHUCCB_6860
SENT: TY21A_03265
STM: STM2213(yeiU)
SEO: STM14_2735(yeiU)
SEV: STMMW_22441
SEY: SL1344_2190(yeiU)
SEM: STMDT12_C22330
SEJ: STMUK_2243(yeiU)
SEB: STM474_2306(yeiU)
SEF: UMN798_2391
SETU: STU288_07450
SETC: CFSAN001921_05720
SENR: STMDT2_21901
SEND: DT104_22721
SENI: CY43_11890
SEEN: SE451236_17265
SPT: SPA0638(yeiU)
SEK: SSPA0599
SPQ: SPAB_00791
SEI: SPC_1487
SEC: SCH_2229(yeiU)
SEH: SeHA_C2450
SHB: SU5_02807
SENH: CFSAN002069_20770
SEEH: SEEH1578_20340
SEE: SNSL254_A2407
SENN: SN31241_33280
SEW: SeSA_A2453
SEA: SeAg_B2362
SENS: Q786_10980
SED: SeD_A2564
SEG: SG2251(yeiU)
SET: SEN2206(yeiU)
SENA: AU38_11150
SENO: AU37_11160
SENV: AU39_11160
SENQ: AU40_12495
SENL: IY59_11460
SENJ: CFSAN001992_00295
SEEC: CFSAN002050_18065
SEEB: SEEB0189_008450
SENB: BN855_23060(yeiU)
SENE: IA1_11070
SENC: SEET0819_18245
SES: SARI_00674
SBG: SBG_2028
SBZ: A464_2344
SBV: N643_09885
SALZ: EOS98_07895
SFL: SF2261
SFX: S2390
SFV: SFV_2252
SFE: SFxv_2495
SFN: SFy_3209
SFS: SFyv_3286
SFT: NCTC1_02484(yeiU)
SSN: SSON_2230
SBO: SBO_2150
SBC: SbBS512_E0784
SDY: SDY_0905
SDZ: Asd1617_01140
SHQ: A0259_14695
ENC: ECL_03493
ENL: A3UG_15695
ECLG: EC036_30480
ECLE: ECNIH2_15670
ECLN: ECNIH4_07515
ECLI: ECNIH5_14615
ECLX: LI66_15015
ECLY: LI62_16515
ECLZ: LI64_14450
ECLO: ENC_39960
EHM: AB284_10405
EXF: BFV63_14835
ECLA: ECNIH3_14710
ECLC: ECR091_14645
EAU: DI57_04055
EKB: BFV64_15285
ENO: ECENHK_15140
EEC: EcWSU1_03086(yeiU)
ELG: BH714_11485
ECAN: CWI88_07245
ERN: BFV67_14730
ECLS: LI67_016280
ECHG: FY206_16785
ESH: C1N69_15525
EPT: HWQ17_20730
ENT: Ent638_2770
EAS: Entas_2941
ENR: H650_06640
ENX: NI40_015185
ENF: AKI40_1640
LNI: CWR52_19900
EBG: FAI37_13965
END: A4308_19810
ENZ: G0034_15755
ENS: HWQ15_00525
ENK: LOC22_03140
EHU: D5067_0007595
EMOR: L6Y89_14830
ENB: ELK40_15545
EQU: OM418_15015
EPU: QVH39_15780
ESA: ESA_01063
CSK: ES15_1310
CSZ: CSSP291_05060
CSJ: CSK29544_02390
CCON: AFK62_13015
CDM: AFK67_13645
CSI: P262_01912
CMJ: AFK66_006380
CUI: AFK65_13360
CMW: AFK63_04975
CTU: CTU_28400(yeiU)
KPN: KPN_02607(yeiU)
KPU: KP1_3836(yeiU)
KPM: KPHS_36730
KPP: A79E_1496
KPH: KPNIH24_10285
KPZ: KPNIH27_17545
KPV: KPNIH29_18320
KPW: KPNIH30_18550
KPY: KPNIH31_17485
KPG: KPNIH32_18880
KPC: KPNIH10_17925
KPQ: KPR0928_17945
KPT: VK055_4914
KPO: KPN2242_16105
KPR: KPR_1483(yeiU)
KPJ: N559_1646
KPI: D364_13285
KPA: KPNJ1_01746
KPS: KPNJ2_01714
KPX: PMK1_00094(yeiU)
KPB: FH42_09155
KPNE: KU54_008045
KPNU: LI86_08055
KPNK: BN49_3824(yeiU)
KVA: Kvar_1453
KPE: KPK_1555
KPK: A593_02855
KVD: KR75_00510
KVQ: SP68_07010
KOX: KOX_25850
KOE: A225_4072
KOY: J415_11715
KOM: HR38_23985
KMI: VW41_15320
KOK: KONIH1_20145
KOC: AB185_16135
KQU: AVR78_22305
EAE: EAE_24065
EAR: CCG29063
KQV: B8P98_08745
KLL: BJF97_20030
KLW: DA718_08865
KAR: LGL98_07745
KGR: JJJ10_08570
KPAS: LUW96_26615
KLC: K7H21_08575
KLM: BWI76_19765
REE: electrica_01534(yeiU)
ROR: RORB6_01470
RON: TE10_19890
RPLN: B1209_07680
RAO: DSD31_07870
RTG: NCTC13098_02095(yeiU)
CRO: ROD_23051
CKO: CKO_00606
CBRA: A6J81_00085
CWE: CO701_06995
CYO: CD187_08190
CPOT: FOB25_19305
CFQ: C2U38_16415
CSED: JY391_08005
CAMA: F384_11675
CAF: AL524_11205
CIF: AL515_15375
CFAR: CI104_17000
CIR: C2U53_26850
CIE: AN232_12905
CPAR: CUC49_11415
CTEL: GBC03_13485
CITZ: E4Z61_01825
CARS: E1B03_17860
CIX: M4I31_08080
CIB: HF677_008175
CENS: P2W74_07870
EBT: EBL_c13410(yeiU)
CNT: JT31_19790
CEM: LH23_21300
CEN: LH86_19895
CLAP: NCTC11466_01379(yeiU)
PGE: LG71_12360
KSA: C813_23450
KOR: AWR26_08390
KRD: A3780_15595
KCO: BWI95_20710
KOT: EH164_07455
KPSE: IP581_15245
KOB: HF650_15870
KOO: O9K67_08105
KIE: NCTC12125_00477(yeiU)
KAS: KATP_14750(lpxT)
KLU: K7B04_21625
KCY: RIN60_07630
LAX: APT61_07155
LEI: C2U54_20435
LEH: C3F35_19300
LEE: DVA44_07345
LER: GNG29_15455
LEA: GNG26_15295
LPNU: KQ929_06340
LEY: DVA43_02090
LAZ: A8A57_14390
LEF: LJPFL01_2839
LEW: DAI21_12240
BUF: D8682_23070
BAGE: BADSM9389_13380
BFT: MNO13_07340
SYM: K6K13_08100
AHN: NCTC12129_01666(yeiU)
ASUB: NLZ15_14640
YRE: HEC60_10430
SGOE: A8O29_007440
KIN: AB182_07285
PDZ: HHA33_10365
METY: MRY16398_16840(lpxT)
IZH: FEM41_21980
PSGC: G163CM_04390(lpxT)
SCOL: KFZ77_13245
PVJ: LMA04_19275
SUPE: P0H77_14490
TOE: QMG90_08220
EBF: D782_1451
EBC: C2U52_17830
EBU: CUC76_23385
EBB: F652_570
PSTS: E05_23980
YPE: YPO1276
YPK: y2907
YPH: YPC_2918(yeiU)
YPA: YPA_0994
YPN: YPN_2700
YPM: YP_1313(pgpB4)
YPP: YPDSF_2418
YPG: YpAngola_A1502
YPZ: YPZ3_1169
YPT: A1122_20285
YPD: YPD4_1130
YPX: YPD8_1015
YPW: CH59_565(yeiU)
YPJ: CH55_1269(yeiU)
YPV: BZ15_2276(yeiU)
YPL: CH46_3851(yeiU)
YPS: YPTB1310
YPO: BZ17_1211(yeiU)
YPI: YpsIP31758_2706
YPY: YPK_2783
YPB: YPTS_1402
YPQ: DJ40_919(yeiU)
YPU: BZ21_584(yeiU)
YPR: BZ20_671(yeiU)
YPC: BZ23_916(yeiU)
YPF: BZ19_717
YEN: YE1434
YEP: YE105_C2681
YEY: Y11_03091
YEL: LC20_03593
YEW: CH47_852(yeiU)
YET: CH48_215(yeiU)
YEF: FORC2_1471
YEE: YE5303_12821
YSI: BF17_15530
YAL: AT01_1063(yeiU)
YIN: CH53_256(yeiU)
YRO: CH64_1130
YRU: BD65_782(yeiU)
YRB: UGYR_04200
YAK: ACZ76_16040
YMA: DA391_14865
YHI: D5F51_05590
YCA: F0T03_08065
YMO: HRD69_18420
YAS: N0H69_10725
YKI: HRD70_12140
YEG: PL78_17095
SMAR: SM39_2809(lpxT)
SMAC: SMDB11_2572(lpxT)
SMW: SMWW4_v1c33400(lpxT)
SPE: Spro_3242
SRR: SerAS9_3383
SRL: SOD_c31560(yeiU)
SRY: M621_17190
SPLY: Q5A_017135(lpxT)
SRS: SerAS12_3384
SRA: SerAS13_3386
SMAF: D781_2993
SLQ: M495_16590
SERF: L085_11970
SERS: SERRSCBI_16130
SFW: WN53_25100
SFG: AV650_20745
SRZ: AXX16_2083
SERM: CLM71_15930
SQU: E4343_24580
SFJ: SAMEA4384070_3355(yeiU)
SOF: NCTC11214_03478(yeiU)
SSUR: ATE40_013225
SURI: J0X03_07315
SRHZ: FO014_18360
SENP: KHA73_16235
SNEM: NLX84_16665
SNEV: OI978_15840
RAH: Rahaq_1326
RACE: JHW33_01135
RAQ: Rahaq2_1403
RAA: Q7S_06385
ROX: BV494_01995
RVC: J9880_14450
RBON: QNM34_06830
RIU: I2123_09025
GQU: AWC35_03735
EAME: GXP68_07050
RBAD: H2866_01085
RCB: O1V66_02815
CARU: P0E69_06455
NIG: C1N62_05350
PROD: PCO85_08645
SERA: Ser39006_016285
SERQ: CWC46_16285
ECA: ECA2734
PATR: EV46_13360
PATO: GZ59_18260
PCT: PC1_1647
PCC: PCC21_016520
PCV: BCS7_08240
PWA: Pecwa_1918
PPAR: A8F97_09245
PEC: W5S_1865
PWS: A7983_16845
PPOA: BJK05_03265
PBRA: B5S52_13475
PPUJ: E2566_08870
PARI: I2D83_09095
PAQU: DMB82_0008530
PVZ: OA04_26310(lpxT)
PPAV: LOZ86_13100
PQU: IG609_007870
PPOO: LW347_08610
PCAC: OI450_07175
PACB: M9782_10710
DDD: Dda3937_03831(yeiU)
DSO: A4U42_18150
CED: LH89_03205
DFN: CVE23_09600
DDA: Dd703_2334
BGJ: AWC36_09615
BNG: EH206_13340
BIZ: HC231_08830
LBQ: CKQ53_15630
LPOP: I6N93_09530
SGL: SG0953
SOD: Sant_1409(lpxT)
SLIG: GTU79_18765
EAM: EAMY_2308(yeiU)
EAY: EAM_2226
ETA: ETA_12710
EPY: EpC_13330
EPR: EPYR_01421(yeiU)
EBI: EbC_30080
ERJ: EJP617_33640
EPE: CI789_03645
ERWI: GN242_06770
ERP: LJN55_15595
ETO: RIN69_15175
EGE: EM595_2451(yeiU)
PAM: PANA_2567(yeiU)
PLF: PANA5342_1509(yeiU)
PAJ: PAJ_1861(yeiU)
PAQ: PAGR_g1462
PVA: Pvag_2049(yeiU)
PAGG: AL522_17140
PAO: Pat9b_2658
KLN: LH22_09230
PANT: PSNIH1_16315
PANP: PSNIH2_04635
PAGC: BEE12_00830
PSTW: DSJ_16430
PALH: B1H58_14020
PANS: FCN45_12950
PEY: EE896_06445
PDIS: D8B20_11415
PER: LAC65_10300
PJI: KTJ90_06220
PANO: OJ965_08710
KPIE: N5580_05725
PALF: K6R05_06330
PPHO: CTZ24_15285
PGZ: C2E15_14005
PCD: C2E16_14125
MINT: C7M51_02010(lpxT)
MTHI: C7M52_00832(lpxT)
MHAN: K6958_13565
TCI: A7K98_13420
TPTY: NCTC11468_02449(yeiU_2)
PLU: plu2863
PLUM: A4R40_14275
PAY: PAU_01673
PAKH: B0X70_14635
PLUI: CE143_14630
PMR: PMI0832
PMIB: BB2000_0948
PVL: AOB99_06590
PVG: CRN77_15175
PHAU: PH4a_13455
PROT: BTA34_05250
PCOL: F1325_07110
PCIB: F9282_06890
XBO: XBJ1_2892(yeiU)
XBV: XBW1_2520(yeiU)
XNE: XNC1_3152(yeiU)
XNM: XNC2_3030(yeiU)
XDO: XDD1_2533(yeiU)
XPO: XPG1_1286(yeiU)
XHO: A9255_08155
XBU: HGO23_08190
XGR: QL128_07495
MMK: MU9_2759
HAV: AT03_07635
HPAR: AL518_17945
OPO: DSM2777_12920
LPV: HYN51_15690
PRAG: EKN56_05455
PFQ: QQ39_11830
LRI: NCTC12151_01317(yeiU)
SEDS: AAY24_17215
CSA: Csal_0690
CCAG: SR908_10895
HEL: HELO_3273
HCO: LOKO_03370(yeiU)
HALO: BWR19_16360
HAF: C8233_09785
HSV: HNO53_18245
HALW: B6N23_07625
HPIS: P1P91_10810
HCAM: I4484_17945
HSX: HNO51_17905
HTX: EKK97_20165
ZPL: ZBT109_1836 ZBT109_1837
HAA: A5892_17715
CMAI: BFX80_15830
CAMH: LCW13_01450
COBE: CLAM6_02880
COBB: H2O77_01345
KUS: B9G99_09770 B9G99_09775
KMA: B9H00_05065 B9H00_05070
KUY: FY550_03130 FY550_03135
SAJS: QO259_12795
AHA: AHA_3523
AHY: AHML_18655
AHD: AI20_01745
AHR: V428_19395
AHP: V429_19425
AHJ: V469_03880
AHH: RY45_18105
AHI: VU14_04075
AAJ: BOQ57_18400
ASA: ASA_0794
AEO: O23A_p2806
AVR: B565_0678
AVO: AMS64_04910
AMED: B224_0509
ASR: WL1483_3679
ADH: CK627_22055
AEM: CK911_13185
AEA: C2U39_04120
ARV: C7N77_07845
AES: C2U30_10120
AEL: NCTC12917_03497(yeiU)
ASIM: FE240_03925 FE240_09805
AALL: I6G90_12270
AJD: I6H43_14425
ASAA: KXJ75_04045
AEJ: E5E97_00030
ABES: IU367_03850
OCE: GU3_03480 GU3_03985
OPE: PU634_14020 PU634_14560
OCM: CBP12_09165 CBP12_11925
OPF: CBP31_06150 CBP31_09430
ZDF: AN401_01035 AN401_16620
ORB: IPMB12_07765
SRI: SELR_09950
PFAC: PFJ30894_00421(yeiU)
 » show all
Reference
1  [PMID:18047581]
  Authors
Touze T, Tran AX, Hankins JV, Mengin-Lecreulx D, Trent MS
  Title
Periplasmic phosphorylation of lipid A is linked to the synthesis of undecaprenyl phosphate.
  Journal
Mol Microbiol 67:264-77 (2008)
DOI:10.1111/j.1365-2958.2007.06044.x
  Sequence
[eco:b2174]
Reference
2  [PMID:20384697]
  Authors
Herrera CM, Hankins JV, Trent MS
  Title
Activation of PmrA inhibits LpxT-dependent phosphorylation of lipid A promoting resistance to antimicrobial peptides.
  Journal
Mol Microbiol 76:1444-60 (2010)
DOI:10.1111/j.1365-2958.2010.07150.x
  Sequence
[eco:b2174]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.4.29
IUBMB Enzyme Nomenclature: 2.7.4.29
ExPASy - ENZYME nomenclature database: 2.7.4.29
BRENDA, the Enzyme Database: 2.7.4.29

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Pathway (2)   
   KEGG PATHWAY (2)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (840)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (577)   
   KEGG MGENES (193)   
   RefGene (69)   
Protein sequence (1882)   
   UniProt (1256)   
   SWISS-PROT (1)   
   RefSeq(pep) (625)   
DNA sequence (44314)   
   RefSeq(nuc) (40367)   
   GenBank (2082)   
   EMBL (1865)   
Protein domain (3)   
   InterPro (3)   
All databases (47047)   

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