KEGG ENZYME: 2.7.4.4

ENZYME: 2.7.4.4

Entry

EC 2.7.4.4                  Enzyme

Name

nucleoside-phosphate kinase;
NMP-kinase

Class

Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with a phosphate group as acceptor

Sysname

ATP:nucleoside-phosphate phosphotransferase

Reaction(IUBMB)

ATP + nucleoside phosphate = ADP + nucleoside diphosphate [RN:R00334]

Reaction(KEGG)

R00334 > R00158 R02098

Substrate

ATP [CPD:C00002];
nucleoside phosphate [CPD:C01329]

Product

ADP [CPD:C00008];
nucleoside diphosphate [CPD:C00454]

Comment

Many nucleotides can act as acceptors; other nucleoside triphosphates can act instead of ATP.

History

EC 2.7.4.4 created 1961

Reference

1 [PMID:13363863]

Authors

AYENGAR P, GIBSON DM, SANADI DR.

Title

Transphosphorylations between nucleoside phosphates.

Journal

Biochim Biophys Acta 21:86-91 (1956)
DOI:10.1016/0006-3002(56)90096-8

Reference

2 [PMID:14401179]

Authors

HEPPEL LA, STROMINGER JL, MAXWELL ES.

Title

Nucleoside monophosphate kinases. II. Transphosphorylation betweeen adenosine monophosphate and nucleoside triphosphates.

Journal

Biochim Biophys Acta 32:422-30 (1959)
DOI:10.1016/0006-3002(59)90615-8

Reference

3 [PMID:14392176]

Authors

LIEBERMAN I, KORNBERG A, SIMMS ES.

Title

Enzymatic synthesis of nucleoside diphosphates and triphosphates.

Journal

J Biol Chem 215:429-40 (1955)

Reference

Authors

Noda, L.

Title

Nucleoside triphosphate-nucleoside monophosphokinases.

Journal

In: Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 6, Academic Press, New York, 1962, p. 139-149.

Other DBs

ExplorEnz - The Enzyme Database:

2.7.4.4

IUBMB Enzyme Nomenclature:

2.7.4.4

ExPASy - ENZYME nomenclature database:

2.7.4.4

BRENDA, the Enzyme Database:

2.7.4.4

CAS:

9026-50-0

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