KEGG ENZYME: 2.7.7.107

ENZYME: 2.7.7.107

Entry

EC 2.7.7.107                Enzyme

Name

(2-aminoethyl)phosphonate cytidylyltransferase;
pntC (gene name)

Class

Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases

Sysname

CTP:(2-aminoethyl)phosphonate cytidylyltransferase

Reaction(IUBMB)

CTP + (2-aminoethyl)phosphonate = diphosphate + CMP-(2-aminoethyl)phosphonate [RN:R04247]

Reaction(KEGG)

R04247

Substrate

CTP [CPD:C00063];
(2-aminoethyl)phosphonate [CPD:C03557]

Product

diphosphate [CPD:C00013];
CMP-2-aminoethylphosphonate [CPD:C05673]

Comment

This bacterial enzyme activates (2-aminoethyl)phosphonate for incorporation into cell wall phosphonoglycans and phosphonolipids, much like EC 2.7.7.15, choline-phosphate cytidylyltransferase, activates phosphocholine for the same purpose.

History

EC 2.7.7.107 created 2021

Pathway

ec00440

Phosphonate and phosphinate metabolism

ec01100

Metabolic pathways

Orthology

K25574

(2-aminoethyl)phosphonate cytidylyltransferase

Genes

BACI:

B1NLA3E_03315

BMQ:

BMQ_0786

BMD:

BMD_0787

BMH:	BMWSH_4462(aepZ)

BMEG:

BG04_3080

PTB:	DER53_11745

PCAL:

BV455_03448(phnW)

MEKU:

HUW50_16415

BOU:	I5818_22330

PPY:

PPE_04393

PKB:	B4V02_16740

PKA:	PQ456_19745

PNK:	AASFL403_21935

OLS:

Olsu_0593

TDE:

TDE_1415

TBE:	Trebr_0277

TPI:	TREPR_2366

TPK:	JO40_09725

TPHG:

FUT81_06845

TRI:	DYE50_04580

TPAV:

HRQ91_06200

TSK:	HRI97_05655

STA:	STHERM_c15590

SBU:	SpiBuddy_0274

TAZ:	TREAZ_2216

SCD:	Spica_1333

BHC:	JFL75_01530

TAR:	TALC_00081

» show all

Reference

1 [PMID:31420548]

Authors

Rice K, Batul K, Whiteside J, Kelso J, Papinski M, Schmidt E, Pratasouskaya A, Wang D, Sullivan R, Bartlett C, Weadge JT, Van der Kamp MW, Moreno-Hagelsieb G, Suits MD, Horsman GP.

Title

The predominance of nucleotidyl activation in bacterial phosphonate biosynthesis.

Journal

Nat Commun 10:3698 (2019)
DOI:10.1038/s41467-019-11627-6

Sequence

[ols:Olsu_0593]

Other DBs

ExplorEnz - The Enzyme Database:

2.7.7.107

IUBMB Enzyme Nomenclature:

2.7.7.107

ExPASy - ENZYME nomenclature database:

2.7.7.107

BRENDA, the Enzyme Database:

2.7.7.107

All links

Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (335)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (28)   
   KEGG MGENES (306)   
Protein sequence (4)   
   UniProt (2)   
   SWISS-PROT (2)   
Protein domain (8)   
   InterPro (8)   
All databases (357)   

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