KEGG ENZYME: 2.7.7.31

ENZYME: 2.7.7.31

Entry

EC 2.7.7.31                 Enzyme

Name

DNA nucleotidylexotransferase;
terminal deoxyribonucleotidyltransferase;
terminal addition enzyme;
addase;
deoxynucleotidyl terminal transferase;
deoxyribonucleic acid nucleotidyltransferase;
deoxyribonucleic nucleotidyltransferase;
terminal deoxynucleotide transferase;
TdT

Class

Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases

Sysname

2'-deoxyribonucleoside-5'-triphosphate:DNA deoxynucleotidylexotransferase

Reaction(IUBMB)

2'-deoxyribonucleoside 5'-triphosphate + DNAn = diphosphate + DNAn+1 [RN:R00379]

Reaction(KEGG)

R00379

Substrate

2'-deoxyribonucleoside 5'-triphosphate [CPD:C00677];
DNAn [CPD:C00039]

Product

diphosphate [CPD:C00013];
DNAn+1 [CPD:C00039]

Comment

Catalyses template-independent extension of the 3'- end of a DNA strand by one nucleotide at a time. Cannot initiate a chain de novo. Nucleoside may be ribo- or 2'-deoxyribo-.

History

EC 2.7.7.31 created 1972

Orthology

K00977

DNA nucleotidylexotransferase

Genes

HSA:	1791(DNTT)

PTR:	466167(DNTT)

PPS:	100976638(DNTT)

GGO:	101139353(DNTT)

PON:	100457001(DNTT)

NLE:	100579985(DNTT)

HMH:	116456795(DNTT)

MCC:	704482(DNTT)

MCF:	102140598(DNTT)

MTHB:

126962079

MNI:	105478468(DNTT)

CSAB:

103216324(DNTT)

CATY:

105581774(DNTT)

PANU:

101004822(DNTT)

TGE:	112631429(DNTT)

MLEU:

105553942(DNTT)

RRO:	104682828(DNTT)

RBB:	108534467(DNTT)

TFN:	117069302(DNTT)

PTEH:

111538742(DNTT)

CANG:

105518286(DNTT)

CJC:	100397804(DNTT)

SBQ:	101034366(DNTT)

CIMI:

108285531(DNTT)

CSYR:

103261490(DNTT)

MMUR:

105872841(DNTT)

LCAT:

123649681(DNTT)

PCOQ:

105818465(DNTT)

OGA:	100963608(DNTT)

MMU:	21673(Dntt)

MCAL:

110285762(Dntt)

MPAH:

110329145(Dntt)

RNO:	294051(Dntt)

MCOC:

116101174(Dntt)

ANU:	117722012(Dntt)

MUN:	110546318(Dntt)

CGE:	100755735(Dntt)

MAUA:

101827000(Dntt)

PROB:

127233335(Dntt)

PLEU:

114706872(Dntt)

MORG:

121454650(Dntt)

MFOT:

126505537

AAMP:

119801080(Dntt)

NGI:	103733214(Dntt)

HGL:	101718847(Dntt)

CPOC:

100717998(Dntt)

CCAN:

109693658(Dntt)

DORD:

105986669(Dntt)

DSP:	122115853(Dntt)

PLOP:

125342944(Dntt)

NCAR:

124985352

MMMA:

107149977(Dntt)

OCU:

100353958

OPI:	101522282(DNTT)

TUP:	102478219(DNTT)

GVR:	103592582(DNTT)

CFA:	486815(DNTT)

CLUD:

112672117(DNTT)

VVP:	112917661(DNTT)

VLG:	121485315(DNTT)

NPO:	129493844(DNTT)

AML:	100481079(DNTT)

UMR:	103672419(DNTT)

UAH:	113251768(DNTT)

UAR:	123783977(DNTT)

ELK:

111145199

LLV:

125085219

MPUF:

101678942(DNTT)

MNP:	132016463(DNTT)

MLK:	131828606(DNTT)

NVS:	122900966(DNTT)

ORO:	101367975(DNTT)

EJU:	114205392(DNTT)

ZCA:	113923793(DNTT)

MLX:	118020756(DNTT)

NSU:	110589348(DNTT)

LWW:	102741185(DNTT)

FCA:	101097099(DNTT)

PYU:	121037047(DNTT)

PCOO:

112854664(DNTT)

PBG:	122493072(DNTT)

PVIV:

125147611(DNTT)

LRUF:

124506703

PTG:	102950975(DNTT)

PPAD:

109272695(DNTT)

PUC:

125933417

AJU:

106984796

HHV:	120230554(DNTT)

BTA:	281120(DNTT)

BOM:	102272669(DNTT)

BIU:	109579068(DNTT)

BBUB:

102406379(DNTT)

BBIS:

104983546(DNTT)

CHX:	102168322(DNTT)

OAS:	101111504(DNTT)

BTAX:

128068013(DNTT)

ODA:	120873741(DNTT)

CCAD:

122445930(DNTT)

MBEZ:

129555968(DNTT)

SSC:	100518694(DNTT)

CFR:	102504796(DNTT)

CBAI:

105081793(DNTT)

CDK:	105084270(DNTT)

VPC:	102525566(DNTT)

BACU:

103011471(DNTT)

BMUS:

118882795(DNTT)

LVE:	103081504(DNTT)

OOR:	101287627(DNTT)

DLE:	111172631(DNTT)

PCAD:

102994470(DNTT)

PSIU:

116741659(DNTT)

NASI:

112393022(DNTT)

ECB:	100061113(DNTT)

EPZ:	103552065(DNTT)

EAI:	106842101(DNTT)

MYB:	102253082(DNTT)

MYD:	102751385(DNTT)

MMYO:

118669916(DNTT)

MLF:	102434921(DNTT)

PKL:	118718954(DNTT)

EFUS:

103288430(DNTT)

MNA:	107542556(DNTT)

DRO:	112307104(DNTT)

SHON:

118990318(DNTT)

AJM:	119044488(DNTT)

PDIC:

114497769(DNTT)

PHAS:

123828914(DNTT)

MMF:	118632487(DNTT)

PPAM:

129077267(DNTT)

HAI:	109380941(DNTT)

RFQ:	117035914(DNTT)

PALE:

102888799(DNTT)

PGIG:

120609697(DNTT)

PVP:	105301367(DNTT)

RAY:	107520451(DNTT)

MJV:	108409011(DNTT)

TOD:	119233784(DNTT)

SARA:

101551596(DNTT)

LAV:	100673573(DNTT)

TMU:

101349757

ETF:	101656457(DNTT)

DNM:	101442590(DNTT)

MDO:	554183(DNTT)

GAS:	123236341(DNTT)

SHR:	100932555(DNTT)

AFZ:

127547151

PCW:	110215362(DNTT)

OAA:	100074260(DNTT)

GGA:	396351(DNTT)

PCOC:

116231747(DNTT)

MGP:	100541055(DNTT)

CJO:	107316113(DNTT)

TPAI:

128077865(DNTT)

LMUT:

125693632(DNTT)

NMEL:

110400293(DNTT)

APLA:

101802023(DNTT)

ACYG:

106039193(DNTT)

CATA:

118245154(DNTT)

AFUL:

116491654(DNTT)

TGU:	100220809(DNTT)

LSR:	110473700(DNTT)

SCAN:

103813904(DNTT)

PMOA:

120501951(DNTT)

OTC:	121341879(DNTT)

PRUF:

121350267(DNTT)

GFR:	102044003(DNTT)

FAB:	101816703(DNTT)

OMA:	130254642(DNTT)

PHI:	102109349(DNTT)

PMAJ:

107206803(DNTT)

CCAE:

111931212(DNTT)

CCW:	104696134(DNTT)

CBRC:

103624524(DNTT)

ETL:	114071228(DNTT)

ZAB:	102066525(DNTT)

ACHL:

103800524(DNTT)

SVG:	106852608(DNTT)

MMEA:

130581287(DNTT)

HRT:	120755753(DNTT)

FPG:	101919206(DNTT)

FCH:	102054379(DNTT)

CLV:	102094484(DNTT)

EGZ:	104129169(DNTT)

NNI:	104012889(DNTT)

PCRI:

104036506(DNTT)

EHS:	104514514(DNTT)

PCAO:

104043800(DNTT)

ACUN:

113481618(DNTT)

TALA:

104361460(DNTT)

PADL:

103916289(DNTT)

AFOR:

103897673(DNTT)

ACHC:

115347985(DNTT)

HALD:

104320522(DNTT)

HLE:	104830156(DNTT)

AGEN:

126042799

GCL:

127017905

CCRI:

104157951(DNTT)

CSTI:

104559628(DNTT)

CMAC:

104486491(DNTT)

MUI:	104544265(DNTT)

BREG:

104632476(DNTT)

FGA:	104069598(DNTT)

GSTE:

104257532(DNTT)

LDI:	104348038(DNTT)

MNB:	103782135(DNTT)

OHA:	104338190(DNTT)

NNT:	104410232(DNTT)

SHAB:

115608145(DNTT)

DPUB:

104297754(DNTT)

ACAR:

104524657(DNTT)

CPEA:

104390843(DNTT)

AVIT:

104272851(DNTT)

CVF:	104289696(DNTT)

RTD:	128911781(DNTT)

CUCA:

104067852(DNTT)

BRHI:

104496185(DNTT)

AAM:	106494703(DNTT)

AROW:

112964185(DNTT)

NPD:	112957371(DNTT)

TGT:	104575938(DNTT)

DNE:	112979750(DNTT)

SCAM:

104145968(DNTT)

ASN:	102384458(DNTT)

AMJ:	102561518(DNTT)

CPOO:

109324044(DNTT)

GGN:	109287517(DNTT)

PSS:	102450678(DNTT)

CMY:	102947062(DNTT)

CCAY:

125640412(DNTT)

DCC:	119858613(DNTT)

CPIC:

101934430(DNTT)

TST:	117880577(DNTT)

CABI:

116818963(DNTT)

MRV:	120369534(DNTT)

ACS:	100561065(dntt)

ASAO:

132770154(DNTT)

PVT:	110079723(DNTT)

SUND:

121926231(DNTT)

PBI:	103057405(DNTT)

PMUR:

107296133(DNTT)

CTIG:

120306901(DNTT)

PGUT:

117673154(DNTT)

APRI:

131200546(DNTT)

PTEX:

113442751(DNTT)

NSS:	113414037(DNTT)

VKO:	123018182(DNTT)

PMUA:

114596810(DNTT)

PRAF:

128413373(DNTT)

ZVI:	118096351(DNTT)

HCG:	128349029(DNTT)

GJA:	107110244(DNTT)

STOW:

125438057(DNTT)

EMC:	129332464(DNTT)

XLA:	378525(dntt.L)

XTR:	100495475(dntt)

NPR:	108788987(DNTT)

RTEM:

120910399(DNTT)

BBUF:

121005503(DNTT)

BGAR:

122942221(DNTT)

MUO:	115471126(DNTT)

GSH:	117359500(DNTT)

DRE:	544653(dntt)

SRX:

107750146

SANH:

107689364 107689760

SGH:	107562388 107565064(dntt)

CCAR:

109061132 109084734

CAUA:

113056613 113077836 113113209 113113212

CGIB:

127969949 128025839

PTET:

122356248(dntt)

LROH:

127175274(dntt)

OMC:	131551737(dntt)

PPRM:

120460955 120460956

RKG:	130069004(dntt)

MAMB:

125276495(dntt)

CIDE:

127525506

MASI:

127412006 127414375

TROS:

130558766(dntt)

TDW:	130431242(dntt)

MANU:

129416672(dntt)

IPU:

108262831

IFU:	128605866(dntt)

PHYP:

113539039(dntt)

SMEO:

124395153(dntt)

TFD:	113660969(dntt)

TVC:	132847466(dntt)

AMEX:

103039195(dntt)

CMAO:

118810640(dntt)

EEE:	113579896(dntt)

CHAR:

105893465(dntt)

TRU:	445927(dntt)

TFS:	130534197(dntt)

TNG:	GSTEN00031681G001

LCO:	104921904(dntt)

TBEN:

117475526(dntt)

CGOB:

115020233(dntt)

PGEO:

117459969(dntt)

GACU:

117551139(dntt)

EMAC:

134859266(dntt)

ELY:	117248468(dntt)

EFO:	125903507(dntt)

PLEP:

121954928(dntt)

SLUC:

116047855(dntt)

ECRA:

117960944(dntt)

ESP:

116705143

PFLV:

114572599(dntt)

GAT:	120820389(dntt)

PPUG:

119214495(dntt)

AFB:	129092620(dntt)

CLUM:

117744438(dntt)

MSAM:

119917012(dntt)

SCHU:

122884807(dntt)

CUD:	121511492(dntt)

ALAT:

119033118(dntt)

MZE:	101468990(dntt)

ONL:	100692116(dntt)

OAU:	116309670(dntt)

OLA:	101161827(dntt)

OML:	112161363(dntt)

CSAI:

133463776(dntt)

XMA:	102220485(dntt)

XCO:	114137448(dntt)

XHE:	116712604(dntt)

PRET:

103477089(dntt)

PFOR:

103131300

PLAI:

106935023

PMEI:

106930456(dntt)

GAF:	122842235(dntt)

PPRL:

129359536

CVG:	107088395(dntt)

CTUL:

119782867(dntt)

GMU:	124859346(dntt)

KMR:	108246559(dntt)

ALIM:

106527857

NWH:	119420755(dntt)

AOCE:

111572840(dntt)

MCEP:

125018400(dntT)

POV:	109631607(dntt)

SSEN:

122781507(dntt)

HHIP:

117775488(dntt)

HSP:	118119090(dntt)

SMAU:

118283757(dntt)

LCF:

108886302

SDU:	111220725(dntt)

SLAL:

111669406(dntt)

XGL:	120796576(dntt)

HCQ:	109523082(dntt)

SSCV:

125978672

SBIA:

133510091(dntt)

PEE:	133409794(dntt)

PTAO:

133485853(dntt)

BPEC:

110166297

MALB:

109960959

BSPL:

114842095(dntt)

SJO:	128372838(dntt)

SASA:

106576788 106605322

STRU:

115153048 115193964

OTW:	112252990 112253405

OMY:	100136754(tdt) 110526770

OGO:	124037185 124040812(dntt)

ONE:	115113350 115135271(dntt)

OKI:	109888751 109899068

OKE:	118369391 118401536

SALP:

111951682 111977656

SNH:	120017546 120045594

CCLU:

121553292 121569188

ELS:	105025934(dntt)

SFM:	108925807(dntt)

PKI:

111850348

AANG:

118218329(dntt)

LOC:	102690875(dntt)

PSPA:

121325345(dntt)

ARUT:

117418578(dntt)

PSEX:

120542898(dntt)

LCM:	102353127(DNTT)

CMK:	103180497(dntt)

RTP:	109913711(dntt) 109929373(polm)

CPLA:

122543109(polm) 122561105(dntt)

HOC:	132826456(dntt) 132836879(polm)

LERI:

129704368 129713196(polm)

LRJ:

133345621

SPU:

591373

LPIC:

129273471 129273472

DPX:	DAPPUDRAFT_300508

DMK:

116921683

SPIS:

111336409

» show all

Reference

1 [PMID:5543689]

Authors

Chang LM, Bollum FJ.

Title

Deoxynucleotide-polymerizing enzymes of calf thymus gland. V. Homogeneous terminal deoxynucleotidyl transferase.

Journal

J Biol Chem 246:909-16 (1971)

Reference

2 [PMID:4288534]

Authors

Gottesman ME, Canellakis ES.

Title

The terminal nucleotidyltransferases of calf thymus nuclei.

Journal

J Biol Chem 241:4339-52 (1966)

Reference

3 [PMID:14459258]

Authors

KRAKOW JS, COUTSOGEORGOPOULOS C, CANELLAKIS ES.

Title

Studies on the incorporation of deoxyribonucleic acid.

Journal

Biochim Biophys Acta 55:639-50 (1962)
DOI:10.1016/0006-3002(62)90842-9

Other DBs

ExplorEnz - The Enzyme Database:

2.7.7.31

IUBMB Enzyme Nomenclature:

2.7.7.31

ExPASy - ENZYME nomenclature database:

2.7.7.31

BRENDA, the Enzyme Database:

2.7.7.31

CAS:

9027-67-2

DBGET integrated database retrieval system