KEGG ENZYME: 2.7.7.82

ENZYME: 2.7.7.82

Entry

EC 2.7.7.82                 Enzyme

Name

CMP-N,N'-diacetyllegionaminic acid synthase;
CMP-N,N'-diacetyllegionaminic acid synthetase;
neuA (gene name);
legF (gene name)

Class

Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases

Sysname

CTP:N,N'-diacetyllegionaminate cytidylyltransferase

Reaction(IUBMB)

CTP + N,N'-diacetyllegionaminate = CMP-N,N'-diacetyllegionaminate + diphosphate [RN:R10182]

Reaction(KEGG)

R10182

Substrate

CTP [CPD:C00063];
N,N'-diacetyllegionaminate [CPD:C20418]

Product

CMP-N,N'-diacetyllegionaminate [CPD:C20419];
diphosphate [CPD:C00013]

Comment

Isolated from the bacteria Legionella pneumophila and Campylobacter jejuni. Involved in biosynthesis of legionaminic acid, a sialic acid-like derivative that is incorporated into virulence-associated cell surface glycoconjugates which may include lipopolysaccharide (LPS), capsular polysaccharide, pili and flagella.

History

EC 2.7.7.82 created 2012

Pathway

ec00520

Amino sugar and nucleotide sugar metabolism

ec01100

Metabolic pathways

Orthology

K18431

CMP-N,N'-diacetyllegionaminic acid synthase

Genes

CITZ:

E4Z61_12365

LEF:	LJPFL01_2718

SRL:	SOD_c14550(ptmB)

SQU:	E4343_08210

SOF:	NCTC11214_05338(neuA)

PPAR:

A8F97_19530

VPH:	VPUCM_0206

VCA:	M892_09465

VOW:	A9237_07125

VAF:	D1115_16670

VNL:	D3H41_01120

VAQ:	FIV01_00050(neuA1)

PMAI:

CF386_03190

PMED:

E3Z27_08385

PVK:	EPZ47_08515

PXA:	KSS93_10455

PSOA:

PSm6_37490(ptmB)

MLQ:	ASQ50_04370

MARJ:

MARI_04490(neuA)

PSYC:

DABAL43B_0735(neuA)

ABZ:	ABZJ_00083

ABD:	ABTW07_0089

ABAB:

BJAB0715_00100

ABAJ:

BJAB0868_00099

ATN:	FM020_15590

SBT:	Sbal678_3131

SBK:	SHEWBE_0693(siaB)

SLIT:

JQC75_12060

SSPA:

K0I31_07180

ILO:	IL0518(siaB)

ILI:	K734_02595 K734_02775

COZ:	A3Q34_06155

COV:	EKO29_16880

PIA:	PI2015_0476

PRR:	AT705_09930

AMK:	AMBLS11_04845

ASP:	AOR13_2478

ASQ:	AVL57_11065

AAW:	AVL56_10205

ALE:	AV939_10085

ALZ:	AV940_09855

PMES:

FX988_03696

PAEW:

KIH87_01875

PMAW:

MACH26_32740

FES:	HER31_10800

MVS:	MVIS_3783(siaB)

MMAA:

FR932_21270

LPN:	lpg0751(neuA)

LPH:	LPV_0877(neuA)

LPO:	LPO_0832(neuA)

LPU:	LPE509_02460

LPM:	LP6_0731(neuA)

LPF:	lpl0788(neuA)

LPP:	lpp0817(neuA)

LPC:	LPC_2541(neuA)

LPA:	lpa_01159(neuA)

LPE:

lp12_0761

LFA:

LFA_0803

LCD:	clem_09295(neuA_1) clem_09325(neuA_2) clem_09390(neuA_3) clem_09460(neuA_4)

LWA:	SAMEA4504053_1065(neuA)

LCAD:

PXX05_08085 PXX05_08230

MDN:	JT25_014965

MDH:	AYM39_17530

MKO:	MKLM6_3560

METL:

U737_04555

MSZE:

MSZNOR_4489

MOZ:	MoryE10_08870

MCAU:

MIT9_P1305

FPH:

Fphi_1170

FPI:

BF30_1414

FPX:

KU46_144

FHA:	CDV26_09110

FRC:

KX01_1743

TCX:

Tcr_1455

HTR:	EPV75_07790

HMAR:

HVMH_1501(neuA)

TAO:	THIAE_07300

THIO:

AYJ59_06125

THIG:

FE785_07400

TSE:	THMIRHAS_08980(neuA)

BLEP:

AL038_07835

TEE:

Tel_05530

THIM:

KFB96_06495

HNA:	Hneap_0634

HAZ:	A9404_06805

GAI:	IMCC3135_21680(neuA_1) IMCC3135_22670(neuA_2)

TBN:

TBH_C0743

HAHE:

ENC22_08715 ENC22_10840

MME:	Marme_0611

AAJ:	BOQ57_08300

AEM:	CK911_04480

ARV:	C7N77_17325

SLIM:

SCL_1208

THO:	SP60_02300 SP60_02365

CHRI:

DK842_11440

CHRB:

DK843_16885

CRZ:	D1345_23645

CARI:

FNU76_04770

PRB:	X636_09640

PIG:	EGT29_04930

POS:	DT070_03515

POO:	F7R28_05925

CBX:	Cenrod_0010(neuA)

MIU:	ABE85_17590

JAJ:	EKL02_02190

HHT:	F506_01245

TIN:

Tint_2653

THI:

THI_3182

NEU:	NE1569(neuA1)

NET:

Neut_1548

NST:	Nstercoris_01519

NMU:	Nmul_A0410

NLC:	EBAPG3_000885

METR:

BSY238_2006

SLAC:

SKTS_36100(neuA)

ACOM:

CEW83_19910

NAF:	GQ61_06870

PMOB:

HG718_03805

PECT:

BN1012_Phect351

RBS:	RHODOSMS8_01664(legF)

SIX:	BSY16_2621

EMX:	FKV68_30735

REL:	REMIM1_CH00778

REI:	IE4771_CH00806

RLG:

Rleg_0443

RRG:	J3P73_04770

RHT:

NT26_3158

BJA:	blr5996(ptmB)

BRC:	BCCGELA001_25440 BCCGELA001_25505

BRAD:

BF49_5664

BOT:	CIT37_24310 CIT37_24405

BRQ:	CIT40_21835 CIT40_21930

BGQ:	X265_13765

BSYM:

CIT39_21125 CIT39_21220

BDG:	LPJ38_31940

BSEI:

KMZ68_19020

BGK:	IC762_24870

RPB:

RPB_1536

RPE:

RPE_4239

NWI:

Nwi_2397

TALZ:

RPMA_09920

MCH:

Mchl_3990

RHZ:	RHPLAN_50180

DEI:	C4375_03860

DEA:	FPZ08_13195

BVR:

BVIR_1973

BLAG:

BLTE_00370

MHEY:

H2LOC_005775

PSIN:

CAK95_17660

RBM:

TEF_17260

BSB:	Bresu_3265

RLI:	RLO149_c044220

OTM:	OSB_23460(legF)

OCT:	FTO60_12850

RPEL:

N7U68_00770

OCD:	FHY55_17140

RCP:	RCAP_rcc02967

RBL:	B6K69_05230

PTP:	RCA23_c02120

DON:	BSK21_04525

RBZ:	B9057_08970 B9057_15025

LVS:	LOKVESSMR4R_02195(legF)

TAW:	EI545_04020

BOO:	E2K80_11645

PSEB:

EOK75_02965

PAED:

G5B38_19515

PAMO:

BAR1_08375

FAQ:	G5B39_16625

CBOT:

ATE48_13360

SAL:	Sala_1578 Sala_1581

SLAN:

GV829_10175

ARUE:

QQX03_02180

ERK:	CD351_01760

ALI:	AZOLI_p60076 AZOLI_p60140(neuA)

AZZ:	DEW08_29930 DEW08_30030

RCE:	RC1_3768(neuA)

MGY:	MGMSRv2__3413(ptmB)

MGRY:

MSR1_31150(neuA)

MAGX:

XM1_0964

MAGN:

WV31_13100

MAG:

amb0088

THAI:

IT893_15770

MAGQ:

MGMAQ_3695 MGMAQ_3718

THAR:

T8K17_13810

MGM:

Mmc1_0559

PEL:	SAR11G3_00107

APM:	HIMB5_00011120

ECOG:

FIV45_02400

HHQ:	HPSH169_04325

HHR:	HPSH417_04095

HPU:	HPCU_04475

HPT:	HPSAT_02535

HEP:	HPPN120_04175

HEU:	HPPN135_04155

HPYK:

HPAKL86_02825

HAC:	Hac_1269(neuA)

HMS:	HMU06140(siaB)

HFE:	HFELIS_02740(siaB)

HBI:	HBZC1_02550

HCE:

HCW_07295

HCM:

HCD_01685

HCP:	HCN_1207 HCN_1208 HCN_1209 HCN_1214

HCB:	HCBAA847_0752 HCBAA847_0757 HCBAA847_0758 HCBAA847_0759

HBL:	XJ32_10875

HAD:	CDV25_02410

HET:	BBW65_04550

HCL:	NCTC13205_00836(siaB)

SULG:

FJR48_00810

SPAL:

FM071_00620

SMAS:

HUE87_09335

SULR:

B649_08520

CJE:	Cj1331(ptmB)

CJB:	BN148_1331(ptmB)

CJJ:	CJJ81176_1161

CJU:

C8J_1333

CJN:	ICDCCJ07001_1101

CJI:	CJSA_1267(ptmB)

CJS:

CJS3_1425

CJP:	A911_06470

CJEJ:

N564_02275

CJEU:

N565_02365

CJEN:

N755_02425

CJEI:

N135_01419

CJER:

H730_07610

CJY:	QZ67_01222(neuA) QZ67_01467(legF_2)

CJQ:	UC78_1274(legF_2)

CJL:	PJ17_05855 PJ17_07040 PJ17_07460

CJW:	PJ18_05665 PJ18_06840

CJR:	CJE1520(ptmB)

CJD:	JJD26997_0378(ptmB)

CJZ:	M635_01415 M635_02350

CJX:	BN867_13160

CCO:	CCC13826_2299(legF)

CCOC:

CCON33237_1634(legF)

CLA:	CLA_1229(legF)

CLL:	CONCH_0311

CCOL:

BN865_08050c BN865_09870c

CCC:	G157_01710 G157_02165

CCQ:	N149_1294(legF)

CCF:

YSQ_02195

CCY:	YSS_06180 YSS_07220 YSS_07635

CCOI:

YSU_02230

CCOF:

VC76_06680(legF_2)

CCOO:

ATE51_00902(legF_2)

CAJ:	CIG1485E_0045 CIG1485E_0047(legF)

CIS:	CINS_1190(legF) CINS_1203(neuA)

CVO:	CVOL_1210(legF)

CSM:	CSUB8521_1413(legF)

CSF:	CSUB8523_1513(legF)

CHV:	CHELV3228_1651(legF)

CLX:	CLAN_1245(legF)

CAVI:

CAV_1245(legF)

CAMZ:

CVIC12175_0318(legF)

CAMY:

CSUIS_1332(legF)

COJ:

CORN_1302

CUX:	CUP3940_0188(legF) CUP3940_0882(neuA)

CBLA:

CBLAS_1484(neuA)

CARM:

CARM_1260(legF)

CMUC:

CMCT_0190(legF)

CNV:	CNZW441b_0378(legF)

CVU:	CVULP_0187(legF)

SBA:	Sulba_1894

ABT:

ABED_0623

ABL:	A7H1H_1746

ATP:

ATR_1810

ACIB:

ACBT_0323

ACRE:

ACRYA_0155

ALAN:

ALANTH_0846

AELL:

AELL_2678

ACLO:

ACLO_2502

ARC:

ABLL_0815

ALK:

ALEK_0983

AMYT:

AMYT_0901

APAI:

APAC_2449

HBV:

ABIV_2485

HCJ:	HCR_18680(legF)

GUR:

Gura_4089

GSUB:

KP001_18470 KP001_19695

GPL:	M1B72_02000 M1B72_03385

GSB:	GSUB_14700

PACE:

A6070_09810

PEF:	A7E78_05545

DEU:

DBW_1496

DFL:	DFE_2596 DFE_2600 DFE_2854

PSYF:

N1030_14900

DDE:

Dde_3257

DHY:	DESAM_21178

DAF:	Desaf_0644

DPI:

BN4_12686

PSEL:

GM415_02260 GM415_04205

PTHE:

LF599_11105

DVM:

DvMF_1844

CLIH:

KPS_002087

DSF:	UWK_02448 UWK_03118

DTO:	TOL2_C35410(neuA)

DMM:	dnm_097120

TAV:	G4V39_08740

BBAE:

FRD01_15930

BBA:	Bd1686(neuA)

BSTO:

C0V70_01595

SBF:	JCM31447_25320 JCM31447_25510

SAQI:

AXG55_11865

BZH:	NF868_08540

BCAO:

LC087_11890

BAEI:

RE735_10220

OCN:	CUC15_16540

ANM:	GFC28_3020

ANL:	GFC29_2415

LSP:

Bsph_1166

LYS:	LBYS11_03265

LYB:	C3943_04100

LYZ:	DCE79_02920

LPAK:

GDS87_03430

LMAC:

I6G82_14980

LYC:	FH508_0003275

LCAP:

ICJ70_21060

LLB:	R6U77_01535

TAID:

KS242_13215

FPN:	ABE65_018200

APAK:

AP3564_07765

POF:	GS400_17635

BVJ:	I5776_04785

FAF:	OE104_15055

AHAL:

FTX54_015180

BBE:	BBR47_53230

BPAB:

PSE45_25510

BHUI:

LOK74_18715

BRUM:

NDK47_24970

PPY:

PPE_04402

PTA:	HPL003_04500

PDU:	PDUR_25205

PPEO:

ABE82_23150

PAIH:

ASL14_14795

PALB:

EJC50_01620

PRZ:	GZH47_18515

PLYC:

GXP70_28080

PTRI:

KDC22_30460

PALO:

E6C60_3855

CCHL:

FPL14_11265

PLIG:

NAG76_07755

AFAS:

NZD89_15280

TUM:	CBW65_04520

TAB:	CIG75_02450

EFF:	skT53_28690

SIV:

SSIL_3274

SOB:	CSE16_03035

SPOS:

DV702_01120

SURL:

BI350_13810

PAEK:

D3873_03375

UTH:	DKZ56_05485

EFC:	EFAU004_01366

EFAU:

EFAU085_00965

EFU:	HMPREF0351_10922(neuA)

AUI:	APT62_03120

CARC:

NY10_945

CNO:	NT01CX_1783

CBN:

CbC4_0995

CKL:	CKL_2466(neuA)

CKR:

CKR_2180

CCB:	Clocel_2195

CEU:	A7L45_12115

CTAE:

BGI42_06500

CFM:	BJL90_21210

CCHV:

BTM20_03700

CGAS:

J1C67_15985

CTAG:

LL095_12340

HHW:	NCTC503_01055(neuA_1)

CTH:

Cthe_2639

CTX:	Clo1313_0228

CCL:	Clocl_4178

HSC:	HVS_09970(legF)

CAPR:

EQM14_03330

DDL:	Desdi_3205

DMT:	DESME_12770

DOR:	Desor_0346

FWA:	DCMF_13700

AACX:

DEACI_3995

AWO:	Awo_c24820(neuA)

THEP:

DYI95_003440

CTHM:

CFE_2504

BPB:	bpr_I0432(neuA1)

ARF:	AR1Y2_2888

PXV:	FXF36_03370

ANR:	Ana3638_07750 Ana3638_07860

LBW:	C3V36_05600

CLE:	Clole_3570

CBAR:

PATL70BA_2647

PSOR:

RSJ16_13970

CST:	CLOST_0369(neuA)

TIT:

Thit_0484

TXY:	Thexy_1873

TSH:

Tsac_2665

MTHO:

MOTHE_c07020(neuA)

MTHZ:

MOTHA_c07960(neuA)

HPK:	Hprae_0329

HALS:

D7D81_05085 D7D81_17920

AFT:	BBF96_11105

COB:	COB47_0923

SPOA:

EQM13_03515

SELO:

AXE86_07145

MANA:

MAMMFC1_02390(neuA)

TUR:	AT726_03470

LPIL:

LIP_2374

FCZ:	IMF26_04550

MSED:

E3O41_11640

HUW:	FPZ11_09620

ARTH:

C3B78_15465

ARI:	UM93_07615

MICK:

B1A86_00002525

RDN:	HMPREF0733_11424

RTER:

IDM49_08865

RAMA:

IDM48_08705

RKR:	I6G21_06730

NAE:	BHE16_04890

DNI:	HX89_10670

DAY:	FV141_09820

TEH:	GKE56_00605

PHW:	G7075_09745

ACTO:

C3V41_10125

PLAN:

A1s21148_00255

NHI:	B1s21160_05765

PBAJ:

LRS13_09225

SYG:	sync_0182(neuA-2)

DSL:	Dacsa_0260 Dacsa_2196

SYW:

SYNW0444

PMB:	A9601_13421

PMH:	P9215_14631

PRC:

EW14_1450

GEN:	GM3709_1255

CWA:	CwatDRAFT_1938

MPRO:

BJP34_15945 BJP34_26760 BJP34_35260

NOP:	Nos7524_1916

NSP:	BMF81_04461(legF)

STOQ:

K2F26_13040

RCS:	NIES932_28440

SCS:	Sta7437_2603

OBG:	Verru16b_02057(neuA)

BVO:	Pan97_06830(neuA)

BREM:

PSR63_07875

RLC:	K227x_18860(neuA)

SNEP:

Enr13x_40710(neuA)

GMR:	GmarT_17210(neuA)

GIM:	F1728_06175

GPN:	Pan110_17040(neuA)

GFM:	Enr17x_19880(neuA)

KST:	KSMBR1_2320(neuA)

PHM:	PSMK_03640

PCOR:

KS4_35120(neuA)

TPED:

TPE_0202

SLR:	L21SP2_3145

SCD:	Spica_0514

LIL:	LA_1605(neuA)

LIE:	LIF_A1292(neuA)

LIC:	LIC_12177(neuA)

LST:

LSS_16491

LAJ:	A0128_07325 A0128_07405

LMAY:

DPV73_15940

LKM:	EFP84_18000

GMA:	AciX8_1507

FVA:	FV113G1_25400

FUL:	C4N20_01270

FMO:	C4N19_03150

FGO:	C4N16_07640

FNF:	BSQ88_01800

BIS:	DXK01_010795

BUN:	Bun01g_24060(neuA)

BNO:	K8P02_14895

BVU:

BVU_4039

BDH:	GV66_21470

TFO:

BFO_1063

DUN:	FDZ78_09645

DDB:	E7747_02795

PII:	NF347_07540

COPR:

Cop2CBH44_22050(neuA)

ASX:	CDL62_03670

CHIH:

GWR21_21010

CSAC:

SIO70_18320

PGIN:

FRZ67_17745

PGO:	FSB84_04805

FLS:	GLV81_12310

PEP:	AQ505_02070

PSTY:

BFS30_06865

PEJ:	FYC62_11645

SDJ:	NCTC13534_05277

SCN:	Solca_4310

MGOS:

DIU38_000405

OLI:	FKG96_05960

ALM:	AO498_13835

DFE:

Dfer_3365

DPF:	ON006_22550

RSI:	Runsl_2327

RUN:	DR864_20415

RUP:	DTQ70_21565

FLI:	Fleli_3536

PACT:

CA264_12425

NIB:	GU926_17070

ASWU:

HUW51_14180

MHAA:

Q3Y49_14240

FBT:	D770_00740

FUV:	JR347_14615

RCG:	N7E81_05755

RSR:	T7867_07400

GFO:	GFO_0572(neuA)

GRL:	LPB144_06580

GFL:

GRFL_2398

GRS:	C7S20_00235

FIN:	KQS_03405(neuA)

FMG:	HYN48_06650

FSE:	DI487_03485

FOK:	KK2020170_01080(neuA)

FAG:	K5I29_08085

COL:	AM608_07330

ZPR:

ZPR_1113

FBC:	FB2170_05775

MART:

BTR34_08485

MARB:

CJ263_08125

LVN:	BWR22_10520

PTQ:	P700755_001634

NDO:

DDD_3551

NOB:	CW736_09225

NOJ:	EJ995_10785

NMF:

NMS_2728

POM:	MED152_05670

POLA:

BXQ17_03855 BXQ17_13945

POA:	CW731_03480

PHAL:

H9I45_03440

PPEC:

H9W90_01225 H9W90_03860

PBAT:

JL193_16070

PCEA:

J3359_01885

WIJ:	BWZ20_06335

TJE:	TJEJU_1147

LUL:	LPB138_01925

WFU:	AXE80_08440

FOP:	FNB79_09380

SALT:

AO058_07935

KOS:	KORDIASMS9_03605(neuA)

KAN:	IMCC3317_05770(neuA)

AFLA:

FHG64_14690

ANP:	FK178_08450

ALTI:

ALE3EI_0108

MUT:	GVT53_17470

AEST:

RBH94_01320

RCL:	NYR17_09600

CJG:	NCTC13459_02718(neuA)

CANT:

NCTC13489_01538(neuA)

FTE:	Fluta_2180

BBAU:

AEM51_03760

PROC:

Ptc2401_00369(neuA)

SRU:

SRU_0608

TTK:	TST_1476(neuA)

DTP:	JZK55_12430 JZK55_12510 JZK55_23620

NDE:	NIDE3000(neuA)

NALL:

PP769_00325

NLI:	G3M70_11120

NWT:	NSPWAT_0142(ptmB)

NVA:	G3M78_01115

PRF:	PeribacterA2_0950

MIB:	UY43_C0001G0714

CGW:	UR58_C0001G0067(neuA)

KBN:	HYS26_04610

NBN:	HYY55_00030

MMQ:	MmarC5_0507

MMAK:

MMKA1_03780

MAE:

Maeo_0417

MSJ:	MSSAC_2014

MSW:	MSSIT_2303

MBU:

Mbur_1585

MEND:

L6E24_13060

MESB:

L1S32_02475

MFO:	Metfor_1312

HABO:

JRZ79_04065

SAIM:

K0C01_02725

HALJ:

G9465_17995

HMU:

Hmuk_1467

HALZ:

E5139_10485

HAZP:

GBQ70_10480

HLS:	KU306_12650

HALQ:

Hrr1229_001175

HSAI:

HPS36_03935

HAE:	halTADL_2402

MAX:	MMALV_05366

NIN:	NADRNF5_2152(neuA)

NZT:	NZOSNM25_001971

NIC:	DSQ20_00895

TAH:	SU86_007060

LOB:	NEF87_004340

AGW:	QT03_C0001G0652

» show all

Reference

1 [PMID:18275154]

Authors

Glaze PA, Watson DC, Young NM, Tanner ME

Title

Biosynthesis of CMP-N,N'-diacetyllegionaminic acid from UDP-N,N'-diacetylbacillosamine in Legionella pneumophila.

Journal

Biochemistry 47:3272-82 (2008)
DOI:10.1021/bi702364s

Sequence

[lpn:lpg0751]

Reference

2 [PMID:19282391]

Authors

Schoenhofen IC, Vinogradov E, Whitfield DM, Brisson JR, Logan SM

Title

The CMP-legionaminic acid pathway in Campylobacter: biosynthesis involving novel GDP-linked precursors.

Journal

Glycobiology 19:715-25 (2009)
DOI:10.1093/glycob/cwp039

Sequence

[cje:Cj1331]

Other DBs

ExplorEnz - The Enzyme Database:

2.7.7.82

IUBMB Enzyme Nomenclature:

2.7.7.82

ExPASy - ENZYME nomenclature database:

2.7.7.82

BRENDA, the Enzyme Database:

2.7.7.82

DBGET integrated database retrieval system