KEGG ENZYME: 2.7.8.14

ENZYME: 2.7.8.14

Entry

EC 2.7.8.14                 Enzyme

Name

CDP-ribitol ribitolphosphotransferase;
teichoic-acid synthase (ambiguous);
polyribitol phosphate synthetase (ambiguous);
teichoate synthetase (ambiguous);
poly(ribitol phosphate) synthetase (ambiguous);
polyribitol phosphate polymerase (ambiguous);
teichoate synthase (ambiguous);
CDP-ribitol:poly(ribitol phosphate) ribitolphosphotransferase

Class

Transferases;
Transferring phosphorus-containing groups;
Transferases for other substituted phosphate groups

Sysname

CDP-ribitol:4-O-di[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol ribitolphosphotransferase

Reaction(IUBMB)

n CDP-ribitol + 4-O-di[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol = n CMP + 4-O-(D-ribitylphospho)n-di[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [RN:R11621 R12869]

Reaction(KEGG)

R11621 R12869(G)

Substrate

CDP-ribitol [CPD:C00789];
4-O-di[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [CPD:C21502]

Product

CMP [CPD:C00055];
4-O-(D-ribitylphospho)n-di[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [CPD:C21508]

Comment

Involved in the biosynthesis of poly ribitol phosphate teichoic acids in the cell wall of the bacterium Staphylococcus aureus. This enzyme adds around 40 ribitol units to the linker molecule.

History

EC 2.7.8.14 created 1972 as EC 2.4.1.55, transferred 1982 to EC 2.7.8.14, modified 2017

Pathway

ec00552

Teichoic acid biosynthesis

Orthology

K18704

CDP-ribitol ribitolphosphotransferase / teichoic acid ribitol-phosphate polymerase

Genes

CCON:

AFK62_03185

ESC:	Entcl_3738

YMA:	DA391_06385

BSUN:

A4G13_01115

APJ:	APJL_1614(cps3A)

VAQ:	FIV01_00150(tagB)

PPR:

PBPRA2702

ALJ:	G8D99_14940

PTN:	PTRA_a0500

PPHE:

PP2015_409

AAL:	EP13_00240

AAUS:

EP12_00250

ASP:	AOR13_2475

ASQ:	AVL57_11050

ALE:	AV939_10070

ALZ:	AV940_09840

TTI:	THITH_00255

HAHE:

ENC22_06700

CHAE:

CH06BL_44160

CKE:	B5M06_15315

HAD:	CDV25_02490

CJS:

CJS3_1521

CJY:	QZ67_01572

CJQ:	UC78_1376(tagB)

CJL:	PJ17_07560

CJR:

CJE1613

CCY:

YSS_07705

CCOF:

VC76_07105(epsJ_2)

CCOO:

ATE51_00688(epsJ_1)

CAVI:

CAV_0458

NAM:

NAMH_1605

DMA:

DMR_40290

DHY:	DESAM_20301

DLM:	DPPLL_12590

BSL:

A7A1_1140

BSY:	I653_17460

BSX:	C663_3471(tarL)

BSS:	BSUW23_17580(tarL)

BST:	GYO_3936(tarL)

BIT:	BIS30_07550

BHT:	DIC78_13170

BMOJ:

HC660_34700(tagB)

BTEQ:

G4P54_18355 G4P54_18385

BIQ:	AN935_18040

BRY:	M0696_18145

BJS:

MY9_3633

BACY:

QF06_16305

BCO:	Bcell_3613

BCIR:

C2I06_13960

BGI:	BGM20_12060

TAID:

KS242_14075

VHL:	BME96_16450

VIG:	BKP57_07895 BKP57_07900

FEC:	QNH15_21935

PPSR:

I6J18_16025

PRD:	F7984_17505 F7984_17510

GAJ:	MY490_02505 MY490_02510

FAF:	OE104_14490

TEI:	QS257_16340

PUK:	PU629_01935

SAU:	SA0243 SA0247

SAV:	SAV0253 SAV0257

SAW:	SAHV_0252 SAHV_0256

SAH:	SaurJH1_0244 SaurJH1_0248

SAJ:	SaurJH9_0238 SaurJH9_0242

SAM:	MW0229 MW0233

SAS:	SAS0229 SAS0234

SAR:	SAR0248 SAR0254

SAC:	SACOL0238 SACOL0242

SAX:	USA300HOU_0264(tagB1) USA300HOU_0268(tagB2)

SAA:	SAUSA300_0247 SAUSA300_0251

SAO:	SAOUHSC_00222 SAOUHSC_00227

SAE:	NWMN_0187 NWMN_0191

SAD:	SAAV_0221 SAAV_0225

SUU:	M013TW_0234 M013TW_0238

SUV:	SAVC_01005 SAVC_01025

SUE:	SAOV_0192 SAOV_0196

SUJ:	SAA6159_00230 SAA6159_00234

SUK:	SAA6008_00226 SAA6008_00231

SUC:	ECTR2_214 ECTR2_218

SUT:	SAT0131_00245 SAT0131_00250

SUQ:	HMPREF0772_10245 HMPREF0772_10250

SUZ:	MS7_0241 MS7_0247

SUD:	ST398NM01_0265 ST398NM01_0270

SUX:	SAEMRSA15_02120 SAEMRSA15_02160

SUW:	SATW20_02550(tarK) SATW20_02590(tarL)

SUG:	SAPIG0265 SAPIG0270

SUF:	SARLGA251_02170(tarK) SARLGA251_02210(tarL)

SAUA:

SAAG_00734 SAAG_00738

SAUE:

RSAU_000197 RSAU_000201

SAUN:

SAKOR_00230 SAKOR_00236

SAUS:

SA40_0211 SA40_0215

SAUU:

SA957_0226 SA957_0230

SAUG:

SA268_0223 SA268_0227

SAUZ:

SAZ172_0255 SAZ172_0260

SAUT:

SAI1T1_2001940 SAI1T1_2001980

SAUJ:

SAI2T2_1001940 SAI2T2_1001980

SAUK:

SAI3T3_1001940 SAI3T3_1001980

SAUQ:

SAI4T8_1001940 SAI4T8_1001980

SAUV:

SAI7S6_1001940 SAI7S6_1001980

SAUW:

SAI5S5_1001930 SAI5S5_1001970

SAUX:

SAI6T6_1001940 SAI6T6_1001980

SAUY:

SAI8T7_1001940 SAI8T7_1001980

SAUF:

X998_0229 X998_0233

SAB:	SAB0192 SAB0196

SUY:	SA2981_0253 SA2981_0257

SAUB:

C248_0240 C248_0245

SAUM:

BN843_2520 BN843_2560

SAUC:

CA347_260 CA347_264

SAUR:

SABB_01595 SABB_01600

SAUI:

AZ30_01270 AZ30_01290

SAUD:

CH52_04440 CH52_04460

SAMS:

NI36_01165 NI36_01185

SUH:	SAMSHR1132_02210 SAMSHR1132_02250

SER:

SERP0198

SEP:

SE_0321

SEPP:

SEB_00243

SEPS:

DP17_1631

SSP:

SSP0356

SCA:

SCA_2404

SXY:	BE24_10200

SXL:	SXYLSMQ121_0384

SXO:	SXYL_00387

SSCH:

LH95_01800

SEQO:

SE1039_21950

SCV:	A4G25_08200 A4G25_08205 A4G25_09305

SPET:

CEP67_06495 CEP67_08275

SKL:	C7J89_03595

SARL:

SAP2_04720

SPIC:

SAMEA4384060_0081

SSH:	NCTC13712_00199(tagF_1) NCTC13712_00203(tagF_3)

SSIM:

SAMEA4384339_0090(tagF_1)

SDB:	CNQ82_01380

SLLO:

ISP08_02340

SPSD:

JMB28_02430 JMB28_13565

SCAQ:

QMO72_02030(tarL)

SROT:

ML435_01080 ML435_01100

STAP:

AOB58_2216

SFF:	FOB90_06000

NMY:	CJ229_008685

LMO:	lmo1077 lmo1085

LMN:	LM5578_1160 LM5578_1168

LMY:	LM5923_1114 LM5923_1122

LMT:	LMRG_00539 LMRG_00547

LMOC:

LMOSLCC5850_1083 LMOSLCC5850_1091

LMOE:

BN418_1295 BN418_1303

LMOB:

BN419_1292 BN419_1300

LMOD:

LMON_1087 LMON_1095

LMOW:

AX10_13965 AX10_14005

LMOQ:

LM6179_01397 LM6179_01405

LMR:	LMR479A_1105 LMR479A_1113

LMOM:

IJ09_04860 IJ09_04900

LMF:	LMOf2365_1097

LMC:	Lm4b_01096

LMOG:

BN389_11100(tarL)

LMP:

MUO_05655

LMOL:

LMOL312_1077

LMOJ:

LM220_05507

LMOZ:

LM1816_14202

LMOX:

AX24_02805

LMH:	LMHCC_1548

LMQ:

LMM7_1109

LML:	lmo4a_1087

LMG:	LMKG_01835 LMKG_01843

LMS:	LMLG_2308 LMLG_2568

LMJ:	LMOG_00633 LMOG_03302

LMW:	LMOSLCC2755_1075 LMOSLCC2755_1083

LMX:	LMOSLCC2372_1091 LMOSLCC2372_1099

LMZ:	LMOSLCC2482_1120 LMOSLCC2482_1129

LMON:

LMOSLCC2376_1050

LMOS:

LMOSLCC7179_1058 LMOSLCC7179_1066

LMOO:

LMOSLCC2378_1094

LMOY:

LMOSLCC2479_1090 LMOSLCC2479_1099

LMOT:

LMOSLCC2540_1073 LMOSLCC2540_1082

LMOA:

LMOATCC19117_1099

LMOK:

CQ02_05615

LMV:	Y193_10350

LIN:

lin1068

LWE:

lwe1060

LSG:	lse_0967 lse_0975

LIV:

LIV_1026

LII:	JL52_05455

LIW:	AX25_05545

LIA:	JL58_05675

LIO:	JL53_06130

LWI:	UE46_11760

LGZ:	NCTC10812_01040(tagF_3) NCTC10812_01812(tagF_6) NCTC10812_01814(tagF_7) NCTC10812_02004(kfoC_3)

LMAR:

LAX80_004980

LNW:	OTR81_10215

ESI:

Exig_0188

EAN:	Eab7_0180(tarL)

EXU:	ESP131_03390

EACE:

KKI46_01210

PCX:	LPB68_14190

PLN:	Plano_2232

PDG:	BCM40_04090

PHC:	BBI08_08415

PGQ:	FK545_05100

KUR:	ASO14_2499

SPOR:

SporoP33_05625

SPOP:

SporoP37_06115

RST:	ATY39_17025

PANC:

E2636_12615

LLK:	LLKF_0947(ggaB)

LLX:	NCDO2118_0939(ggaB)

LLJ:	LG36_1406(ggaB)

LCAR:

BHS00_06080

LPL:	lp_1819(tarL)

LPJ:	JDM1_1532(tagB2)

LPT:	zj316_1807(tarL)

LPS:	LPST_C1461(tagB2)

LPR:	LBP_cg1415

LPZ:

Lp16_1408

LPB:	SH83_07570

LPX:	ASU28_07570

LPG:	BB562_08390

LARG:

LPA65_07290

PCE:

PECL_1837

PIO:	PI20285_08410

LEC:	LGMK_03545

WCE:

WS08_0699

WTR:	KHQ32_03755

WCT:

WS74_0701

WCI:	WS105_0761

WCB:	AO080_09205

WJO:	FOL01_0725

WHE:	EFA59_03560

WVR:	IE337_04450

TEY:	GLW17_02095

VTE:	BHY08_07870

VPI:	BW732_01925

CBT:

CLH_2994

CLS:	CXIVA_01260

CBV:

U729_1133

RAL:	Rumal_1248

RUS:	RBI_I00537 RBI_I01994

ALKA:

J0B03_04345

EUU:	ADJ67_05825

RIX:

RO1_35060

RIM:

ROI_04730

RRK:	H8S51_015580

BLAB:

EYS05_02830

BLAR:

LC508_26875

BCOC:

BLCOC_40530

LACY:

A4V08_21485

HSD:

SD1D_2042

EHL:	EHLA_1018 EHLA_2957 EHLA_2962 EHLA_3127 EHLA_3144

ERE:	EUBREC_2652

LBX:	lbkm_2929 lbkm_2930 lbkm_2931

PSOR:

RSJ16_02160

KPAR:

JL105_07995

AARG:

Aargi30884_26940(tagB)

ABSI:

A9CBEGH2_00110(tagB)

EBM:	SG0102_21250 SG0102_21290

LCG:	L3BBH23_26570

ERM:	EYR00_06710

CMIT:

NQ499_09020

SHI:	Shel_14500 Shel_14640

AEQ:

AEQU_0651

AHAT:

ADCFC_17250

DDT:	AAY81_07475

SCYE:

R2B67_11495

LXL:	KDY119_02610(tarL)

MOO:	BWL13_02197(tarL)

MELY:

L2X98_21170

MEST:

PTQ19_14610

ARN:	CGK93_08975

ACIT:

HPK19_20705

JDE:

Jden_1795

XCE:

Xcel_2590

IDO:	I598_2371(tagF_2)

PHW:	G7075_10605

AEZ:	C3E78_05610

AEF:	GEV26_05360

MGG:	MPLG2_2612(tagB)

BBP:	BBPR_0698 BBPR_0699(tagB)

BBI:	BBIF_0729 BBIF_0730

BBF:	BBB_0690(tarK) BBB_0691

SNG:	SNE_A00880

FMO:	C4N19_12415

OSP:	Odosp_3547

BUY:	D8S85_08740

BVIR:

I6J59_07105

PIT:	PIN17_A0661

POC:	NCTC13071_00553 NCTC13071_01724

DOK:	MED134_02960

DDO:

I597_2601

LUT:	Lupro_03965

TRQ:

TRQ2_0300

MRU:

mru_1079

MSI:

Msm_1327

MEB:

Abm4_1699

MMIL:

sm9_2259

MEYE:

TL18_00335

MOL:

YLM1_0599

MARO:

MarbSA_12200

METV:

K4897_04690

MCUB:

MCBB_1531(tarL)

HALJ:

G9465_17790

» show all

Reference

1 [PMID:5908130]

Authors

Ishimoto N, Strominger JL.

Title

Polyribitol phosphate synthetase of Staphylococcus aureus.

Journal

J Biol Chem 241:639-50 (1966)

Reference

2 [PMID:18215769]

Authors

Brown S, Zhang YH, Walker S

Title

A revised pathway proposed for Staphylococcus aureus wall teichoic acid biosynthesis based on in vitro reconstitution of the intracellular steps.

Journal

Chem Biol 15:12-21 (2008)
DOI:10.1016/j.chembiol.2007.11.011

Sequence

[sao:SAOUHSC_00227]

Reference

3 [PMID:18556787]

Authors

Pereira MP, D'Elia MA, Troczynska J, Brown ED

Title

Duplication of teichoic acid biosynthetic genes in Staphylococcus aureus leads to functionally redundant poly(ribitol phosphate) polymerases.

Journal

J Bacteriol 190:5642-9 (2008)
DOI:10.1128/JB.00526-08

Reference

4 [PMID:21035733]

Authors

Brown S, Meredith T, Swoboda J, Walker S

Title

Staphylococcus aureus and Bacillus subtilis W23 make polyribitol wall teichoic acids using different enzymatic pathways.

Journal

Chem Biol 17:1101-10 (2010)
DOI:10.1016/j.chembiol.2010.07.017

Other DBs

ExplorEnz - The Enzyme Database:

2.7.8.14

IUBMB Enzyme Nomenclature:

2.7.8.14

ExPASy - ENZYME nomenclature database:

2.7.8.14

BRENDA, the Enzyme Database:

2.7.8.14

CAS:

9076-71-5

DBGET integrated database retrieval system