KEGG ENZYME: 2.7.8.23

ENZYME: 2.7.8.23

Entry

EC 2.7.8.23                 Enzyme

Name

carboxyvinyl-carboxyphosphonate phosphorylmutase

Class

Transferases;
Transferring phosphorus-containing groups;
Transferases for other substituted phosphate groups

Sysname

1-carboxyvinyl carboxyphosphonate phosphorylmutase (decarboxylating)

Reaction(IUBMB)

1-carboxyvinyl carboxyphosphonate = 3-(hydroxyphosphinoyl)pyruvate + CO2 [RN:R05165]

Reaction(KEGG)

R05165;
(other) R08868 R08869

Substrate

1-carboxyvinyl carboxyphosphonate [CPD:C06367]

Product

3-(hydroxyphosphinoyl)pyruvate;
CO2 [CPD:C00011]

Comment

Catalyses the transfer and decarboxylation of the carboxy(hydroxy)phosphoryl group, HOOC-P(O)(OH)- (phosphoryl being a 3-valent group), in the formation of an unusual C-P bond that is involved in the biosynthesis of the antibiotic bialaphos.

History

EC 2.7.8.23 created 1999

Pathway

ec00440

Phosphonate and phosphinate metabolism

ec01110

Biosynthesis of secondary metabolites

Orthology

K12909

carboxyvinyl-carboxyphosphonate phosphorylmutase

Reference

1 [PMID:1330557]

Authors

Pollack SJ, Freeman S, Pompliano DL, Knowles JR

Title

Cloning, overexpression and mechanistic studies of carboxyphosphonoenolpyruvate mutase from Streptomyces hygroscopicus.

Journal

Eur J Biochem 209:735-43 (1992)
DOI:10.1111/j.1432-1033.1992.tb17342.x

Sequence

[ag:CAA48139]

Reference

2 [PMID:3611020]

Authors

Anzai H, Murakami T, Imai S, Satoh A, Nagaoka K, Thompson CJ

Title

Transcriptional regulation of bialaphos biosynthesis in Streptomyces hygroscopicus.

Journal

J Bacteriol 169:3482-8 (1987)
DOI:10.1128/JB.169.8.3482-3488.1987

Other DBs

ExplorEnz - The Enzyme Database:

2.7.8.23

IUBMB Enzyme Nomenclature:

2.7.8.23

ExPASy - ENZYME nomenclature database:

2.7.8.23

BRENDA, the Enzyme Database:

2.7.8.23

CAS:	122799-57-9

DBGET integrated database retrieval system