Entry
Name
carboxyvinyl-carboxyphosphonate phosphorylmutase
Class
Transferases;
Transferring phosphorus-containing groups;
Transferases for other substituted phosphate groups
BRITE hierarchy
Sysname
1-carboxyvinyl carboxyphosphonate phosphorylmutase (decarboxylating)
Reaction(IUBMB)
1-carboxyvinyl carboxyphosphonate = 3-(hydroxyphosphinoyl)pyruvate + CO2 [RN:
R05165 ]
Reaction(KEGG)
Substrate
1-carboxyvinyl carboxyphosphonate [CPD:
C06367 ]
Product
3-(hydroxyphosphinoyl)pyruvate;
CO2 [CPD:
C00011 ]
Comment
Catalyses the transfer and decarboxylation of the carboxy(hydroxy)phosphoryl group, HOOC-P(O)(OH)- (phosphoryl being a 3-valent group), in the formation of an unusual C-P bond that is involved in the biosynthesis of the antibiotic bialaphos.
History
EC 2.7.8.23 created 1999
Pathway
ec00440 Phosphonate and phosphinate metabolism
ec01110 Biosynthesis of secondary metabolites
Orthology
K12909 carboxyvinyl-carboxyphosphonate phosphorylmutase
Reference
Authors
Pollack SJ, Freeman S, Pompliano DL, Knowles JR
Title
Cloning, overexpression and mechanistic studies of carboxyphosphonoenolpyruvate mutase from Streptomyces hygroscopicus.
Journal
Sequence
Reference
Authors
Anzai H, Murakami T, Imai S, Satoh A, Nagaoka K, Thompson CJ
Title
Transcriptional regulation of bialaphos biosynthesis in Streptomyces hygroscopicus.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 2.7.8.23
ExPASy - ENZYME nomenclature database: 2.7.8.23