KEGG ENZYME: 2.7.8.38

ENZYME: 2.7.8.38

Entry

EC 2.7.8.38                 Enzyme

Name

archaetidylserine synthase

Class

Transferases;
Transferring phosphorus-containing groups;
Transferases for other substituted phosphate groups

Sysname

CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol:L-serine 2,3-bis-(O-geranylgeranyl)-sn-glycerol phosphotransferase

Reaction(IUBMB)

(1) CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol + L-serine = CMP + 2,3-bis-(O-geranylgeranyl)-sn-glycero-1-phospho-L-serine [RN:R10255];
(2) CDP-2,3-bis-(O-phytanyl)-sn-glycerol + L-serine = CMP + 2,3-bis-(O-phytanyl)-sn-glycero-1-phospho-L-serine [RN:R10441]

Reaction(KEGG)

R10255 R10441

Substrate

CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol [CPD:C18059];
L-serine [CPD:C00065];
CDP-2,3-bis-(O-phytanyl)-sn-glycerol [CPD:C20627]

Product

CMP [CPD:C00055];
2,3-bis-(O-geranylgeranyl)-sn-glycero-1-phospho-L-serine [CPD:C20466];
2,3-bis-(O-phytanyl)-sn-glycero-1-phospho-L-serine [CPD:C20628]

Comment

Requires Mn2+. Isolated from the archaeon Methanothermobacter thermautotrophicus.

History

EC 2.7.8.38 created 2013, modified 2013

Pathway

ec00564

Glycerophospholipid metabolism

ec01110

Biosynthesis of secondary metabolites

Orthology

K19665

archaetidylserine synthase

Genes

EPS:	L0Y14_09115

MJA:

MJ_1212

MFE:	Mefer_0273

MVU:	Metvu_1372

MFS:	MFS40622_0843

MIF:	Metin_0469

MJH:	JH146_0624

MESG:

MLAUSG7_0063(pssA)

MESA:

MLASG1_1245(pssA)

MIG:	Metig_0758

MMP:	MMP1171(pssA)

MMQ:	MmarC5_0416

MMX:	MmarC6_1500

MMZ:	MmarC7_0419

MMD:

GYY_06700

MMAK:

MMKA1_13490(pssA)

MMAO:

MMOS7_12790(pssA)

MMAD:

MMJJ_16740

MAE:

Maeo_1058

MVN:	Mevan_0491

MVO:

Mvol_0960

MOK:	Metok_1327

METF:

CFE53_05690(pssA)

MTH:

MTH_1027

MMG:	MTBMA_c14090(pssA)

MWO:	MWSIV6_1413

MTEE:

MTTB_03960

METC:

MTCT_0935

METE:

tca_00988

METZ:

METMT2_1053

METK:

FVF72_06475(pssA)

MTHM:

FZP57_06755(pssA)

METJ:

FZP68_03905(pssA)

MST:

Msp_1394

METB:

AW729_08535

MEIS:

PXD04_00100(pssA)

MRU:	mru_1834(pssA)

MSI:

Msm_0982

MEB:

Abm4_1497

MMIL:

sm9_1037(pssA)

MEYE:

TL18_09180

MOL:

YLM1_1292

MARO:

MarbSA_17000

METV:

K4897_06565

MEL:	Metbo_2427

MEW:	MSWAN_0215

METH:

MBMB1_0210

MFC:	BRM9_2090(pssA)

MFI:	DSM1535_1591

MCUB:

MCBB_0224

MSUB:

BK009_10845

METN:

BK008_06485

METT:

CIT01_02880(pssA)

METO:

CIT02_05970(pssA)

MEME:

HYG87_04370

MFEG:

GCM10025860_10300

MKA:	MK0161(pssA)

AFU:

AF_2044

AFG:	AFULGI_00023120

APO:	Arcpr_0869

AVE:	Arcve_0399

AST:	Asulf_01999

FPL:

Ferp_1409

GAC:

GACE_0950

GAH:

GAH_01927

MBA:	Mbar_A0874

MBY:	MSBRM_0121

MBW:	MSBRW_0124

MBAR:

MSBR2_2259

MBAK:

MSBR3_2310

MAC:	MA_0116(pss)

MMA:

MM_1403

MMAZ:

MmTuc01_1461

MMJ:	MSMAS_3260

MMAC:

MSMAC_3281

MVC:	MSVAZ_3392

MEK:	MSKOL_3352

MLS:	MSLAZ_3173

METM:

MSMTP_1929 MSMTP_3154

MEF:	MSWH1_3106

MEQ:	MSWHS_3315

MSJ:	MSSAC_0094

MSZ:	MSSIH_0084

MSW:	MSSIT_0085

MTHR:

MSTHT_1900

MTHE:

MSTHC_1383

MHOR:

MSHOH_4008

MFZ:	AOB57_008805

MBU:	Mbur_0786 Mbur_2198

MMET:

MCMEM_0374

MELO:

J7W08_03755 J7W08_12000

MMH:

Mmah_0393

MHAZ:

BHR79_01540

MPOT:

BKM01_06910

MEV:	Metev_1119

MZH:	Mzhil_1683

MPY:

Mpsy_2327

MZI:	HWN40_10705

MMAV:

RE476_12330

MSEB:

RE474_09245

MHZ:	Metho_0453

MEHF:

MmiHf6_15280

MEES:

MmiEs2_00770

MTP:

Mthe_1331

MCJ:	MCON_0461(pssA)

MHI:

Mhar_2192

HAL:	VNG_0784G(pssA)

HSL:	OE_2155R(pgsA3)

HANR:

LJ422_03225

HDL:	HALDL1_08325

HHB:	Hhub_1848(pgsA1)

HAGS:

JT689_04500

HABO:

JRZ79_03005

HNO:	LT974_04195

HLU:	LT972_08415

HALH:

HTSR_1242(pssA)

HHSR:

HSR6_1314(pssA)

HSU:	HLASF_1159(pssA)

HSF:	HLASA_1147(pssA)

HAHS:

HSRCO_1412(pssA)

SALR:

FQU85_10535

HALR:

EFA46_008265

HJE:	HacjB3_10815

HDO:	MUK72_09135

HALX:

M0R89_13810

HAYC:

NGM10_03545

HAXY:

NGM07_19130

SALI:

L593_13620

SAIM:

K0C01_00080

HARA:

AArcS_2035(pssA)

HMA:	rrnAC0788(pssA)

HHI:	HAH_1434(pssA)

HHN:	HISP_07325

HAB:	SG26_15170

HTA:	BVU17_06970

HALJ:

G9465_12530

HSIN:

KDQ40_06320

NPH:	NP_3230A(assA)

NMO:	Nmlp_1867(pgsA3)

NHO:	HWV23_04800

NSAL:

HWV07_04835

HUT:

Huta_0720

HTI:

HTIA_0627

HALA:

Hrd1104_09390

HASV:

SVXHr_0873(pssA)

HABN:

HBNXHr_0864(pssA)

HMU:

Hmuk_2392

HALZ:

E5139_15090

HALL:

LC1Hm_1749(pssA)

HAZP:

GBQ70_15110

HALI:

BV210_02670

HSN:	DV733_01725

HDS:	HSR122_1044(pssA)

HRR:	HZS55_15510

HPEL:

HZS54_18560

HLT:	I7X12_20080

SSAI:

N0B31_02875

HAAD:

MW046_10585

HWA:	HQ_2356A(assA)

HWC:	Hqrw_2603(assA)

HVO:	HVO_1143(assA)

HME:	HFX_1155(pssA)

HGI:	ABY42_05580

HALE:

G3A49_08935

HLS:	KU306_10430

HLN:	SVXHx_1097(pssa)

HBO:	Hbor_20980

HAQ:	DU484_14580

HAJ:	DU500_14610

HAER:

DU502_12740

HRA:	EI982_05010

HLM:	DV707_10315

HALM:

FCF25_12415

HLA:

Hlac_0607

HALP:

DOS48_02905

HALB:

EKH57_08310

HEZZ:

EO776_04185

HALQ:

Hrr1229_003130

HSS:	J7656_12675

HSAI:

HPS36_03020

HAZZ:

KI388_01670

SRUB:

C2R22_07300

HAE:	halTADL_3140

HALN:

B4589_002185

HALG:

HUG10_02765

HALU:

HUG12_13975

HMP:	K6T50_00685

HRE:	K6T36_00905

HRM:	K6T25_00325

HACB:

Hbl1158_08105

HDF:	AArcSl_2371(pssA)

HAH:	Halar_1044

HTU:

Htur_1508

HSAL:

JMJ58_01155

HAKZ:

J0X25_14405

NMG:	Nmag_2425(assA)

HXA:	Halxa_2866

NAT:

NJ7G_3135

NPE:	Natpe_2768

NVR:	FEJ81_12770

NPL:	FGF80_12520

NAY:	HYG81_16135

HALY:

HYG82_00155

HJT:	DVR14_03780

HLO:	J0X27_12315

NGE:	Natgr_0924

HRU:	Halru_0823

SAWL:

NGM29_16905

HALV:

NGM15_07950

NOU:	Natoc_0839

HLR:	HALLA_09750

HLC:	CHINAEXTREME16935

NAJ:	B1756_01745

NAG:	AArcMg_1128

NAN:	AArc1_2494

NARA:

QQ977_14810

NBG:	DV706_12735

NAS:	GCU68_13485

HDA:	BB347_03740

PDL:	Pyrde_1316

FFO:	FFONT_0336

LOKI:

Lokiarch_19230 Lokiarch_20140

PSYT:

DSAG12_02960

» show all

Reference

1 [PMID:12562787]

Authors

Morii H, Koga Y

Title

CDP-2,3-Di-O-geranylgeranyl-sn-glycerol:L-serine O-archaetidyltransferase (archaetidylserine synthase) in the methanogenic archaeon Methanothermobacter thermautotrophicus.

Journal

J Bacteriol 185:1181-9 (2003)
DOI:10.1128/JB.185.4.1181-1189.2003

Sequence

[mth:MTH_1027]

Other DBs

ExplorEnz - The Enzyme Database:

2.7.8.38

IUBMB Enzyme Nomenclature:

2.7.8.38

ExPASy - ENZYME nomenclature database:

2.7.8.38

BRENDA, the Enzyme Database:

2.7.8.38

DBGET integrated database retrieval system