KEGG ENZYME: 2.7.8.46

ENZYME: 2.7.8.46

Entry

EC 2.7.8.46                 Enzyme

Name

teichoic acid ribitol-phosphate primase;
Tar primase;
tarK (gene name)

Class

Transferases;
Transferring phosphorus-containing groups;
Transferases for other substituted phosphate groups

Sysname

CDP-ribitol:4-O-[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol ribitylphosphotransferase

Reaction(IUBMB)

CDP-ribitol + 4-O-[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol = CMP + 4-O-[1-D-ribitylphospho-(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [RN:R11613 R12864]

Reaction(KEGG)

R11613 R12864(G)

Substrate

CDP-ribitol [CPD:C00789];
4-O-[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [CPD:C21464]

Product

CMP [CPD:C00055];
4-O-[1-D-ribitylphospho-(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [CPD:C21503]

Comment

Involved in the biosynthesis of teichoic acid linkage units in the cell wall of Bacillus subtilis W23. This enzyme adds the first ribitol unit to the disaccharide linker of the teichoic acid.

History

EC 2.7.8.46 created 2017

Pathway

ec00552

Teichoic acid biosynthesis

Orthology

K21592

teichoic acid ribitol-phosphate primase

Genes

BSL:

A7A1_1141

BSY:	I653_17455

BSUS:

Q433_19605

BSX:	C663_3470(tarK)

BSS:	BSUW23_17575(tarK)

BST:	GYO_3935(tarK)

BIT:	BIS30_07545

BHT:	DIC78_13175

BMOJ:

HC660_34690

BTEQ:

G4P54_18380

BIQ:	AN935_18035

BRY:	M0696_18140

BJS:

MY9_3632

BACY:

QF06_16300

BGI:	BGM20_12055

TAID:

KS242_14080

FEC:	QNH15_21940

PRD:	F7984_17515

BLEN:

NCTC4824_03821(tarK)

BVJ:	I5776_16310

FAF:	OE104_14485

PUK:	PU629_01930

ESI:

Exig_0191

EAN:	Eab7_0183(tarK)

EXU:	ESP131_03405

EACE:

KKI46_01225

LCAR:

BHS00_06055

CBV:

U729_1136

ALKA:

J0B03_04335 J0B03_04340

WCP:	H9Q76_02900 H9Q76_02905

ETM:	CE91St48_15330

TEM:	JW646_10245

FIT:	Fi14EGH31_11100(tagB)

CIU:	G4D55_18420

AHAT:

ADCFC_17170

RTS:	CE91St31_00290

MEST:

PTQ19_14615

LTN:	KVY00_06745

» show all

Reference

1 [PMID:21035733]

Authors

Brown S, Meredith T, Swoboda J, Walker S

Title

Staphylococcus aureus and Bacillus subtilis W23 make polyribitol wall teichoic acids using different enzymatic pathways.

Journal

Chem Biol 17:1101-10 (2010)
DOI:10.1016/j.chembiol.2010.07.017

Sequence

[bss:BSUW23_17575]

Other DBs

ExplorEnz - The Enzyme Database:

2.7.8.46

IUBMB Enzyme Nomenclature:

2.7.8.46

ExPASy - ENZYME nomenclature database:

2.7.8.46

BRENDA, the Enzyme Database:

2.7.8.46

DBGET integrated database retrieval system