KEGG ENZYME: 2.7.8.48

ENZYME: 2.7.8.48

Entry

EC 2.7.8.48                 Enzyme

Name

ceramide phosphoethanolamine synthase;
Cpes (gene name);
CPE synthase

Class

Transferases;
Transferring phosphorus-containing groups;
Transferases for other substituted phosphate groups

Sysname

CDP-ethanolamine:ceramide phosphoethanolaminyltransferase

Reaction(IUBMB)

CDP-ethanolamine + a ceramide = a ceramide phosphorylethanolamine + CMP [RN:R01503]

Reaction(KEGG)

R01503

Substrate

CDP-ethanolamine [CPD:C00570];
ceramide [CPD:C00195]

Product

ceramide phosphorylethanolamine;
CMP [CPD:C00055]

Comment

The enzyme, studied from the fly Drosophila melanogaster, has homologues among the invertebrates, but not in other animal phyla. Its product, ceramide phosphoethanolamine, is synthesized as the main sphingolipid in cell membranes of arthropods, such as Drosophila and Musca, and is common in worms, bees, spiders, and scorpions. It has also been reported in deep-sea mussels and some sea snails, as well as protozoans and oomycetes. The enzyme requires a Mn(II) cofactor.

History

EC 2.7.8.48 created 2022

Pathway

ec00600

Sphingolipid metabolism

Orthology

K26283

ceramide phosphoethanolamine synthase

Genes

DME:	Dmel_CG4585(Cpes)

DER:

6548017

DSE:

6615787

DSI:	Dsimw501_GD25004(Dsim_GD25004)

DYA:	Dyak_GE11520

DAN:

6494919

DSR:

110191497

DPO:

26534028

DPE:

6590368

DMN:	108160581 117190958

DWI:

6641049

DMO:	Dmoj_GI20723

DAZ:

108616641

DNV:

108652965

DHE:

111600017

DVI:	116651094 6625014

CCAT:

105664470

BOD:

106626898

BDR:

109579586

RZE:

108359268

AOQ:

129244607

TDA:	119661876 119661929 119679379 119683850

MDE:

101900101

LCQ:

111677038

CLON:

129609909

HIS:

119656308

ACOZ:

120959226

AARA:

120904060

AMER:

121598679

ASTE:

118504095

AFUN:

125767051

AMOU:

128310341

AALI:

118462767

AAG:

5563823

AALB:

109623351

CQU:	CpipJ_CPIJ017392

CPII:

120422957

CNS:

116349052

BCOO:

119082369

ACER:

107997556

ALAB:

122711578

BIM:

105680864

BBIF:

117208330

BVK:

117237731

BVAN:

117157992

BTER:

105666543

BAFF:

126918767

BPYO:

122577005

BPAS:

132908421

FVI:

122527739

CCAL:

108632699

OBB:

114871911

MGEN:

117225071

CGIG:

122402301

SOC:

105207917

MPHA:

105830809 105840354

PBAR:

105427572

VEM:

105569516

HST:

105185092

DQU:

106744003

CFO:

105249576

FEX:

115238445

LHU:

105670787

PGC:

109860914

OBO:

105277222

PCF:

106793553

PFUC:

122515659

VPS:

122632296

VCRB:

124427225

VVE:

124951068

NVI:

107980947

CSOL:

105366345

TPRE:

106650334

LHT:

122499655

LBD:

127278833

CGLO:

123268518

FAS:

105266352

AGIF:

122858141

DSM:

124414926

NPT:

124223567

NFB:

124186325

NLO:

107222915

NVG:

124308368

AROA:

105690704

DPA:

109546868

SOY:

115887345

AGRG:

126735409

CSET:

123322866

AGB:

108914434

LDC:

111510677

NVL:

108563771

PPYR:

116180598

OTU:

111417168

BMOR:

101737048

BMAN:

114241042

MSEX:

115453083

DPL:	KGM_207691

BANY:

112046696

MJU:

123878129

NIQ:

126778522

VCD:

124540705

MCIX:

123667545

PMAC:

106711765

PPOT:

106108885

PXU:

106113472

PRAP:

110992867

PBX:

123720878

PNAP:

125052367

ZCE:

119835982

CCRC:

123703716

LSIN:

126976185

AAGE:

121737999

HAW:

110377854

HZE:

124642903

TNL:

113505072

SLIU:

111358046

OFU:

114350759

PXY:

105393507

PGW:

126378143

CFEL:

113382717 113382933

CCRN:

123293973

CSEC:

111873192

IEL:	124158055 124170790

TCF:

131881032

DSV:

119433103

RSAN:

119405065

RMP:

119180600

VDE:

111250463

VJA:

111261934

TUT:

107359969

CSCU:

111634940

PTEP:

107443179

ABRU:

129981013

UDV:

129227044

SDM:

118204435

LPOL:

106471127

LGI:	LOTGIDRAFT_237577

PVUL:

126829548

PCAN:

112559354

BGT:

106057937

GAE:

121376347

HRF:	124132655 124134454

HRJ:	124272727 124274695

CRG:

105341300

CVN:	111125476 111125840

CANU:

128192953

OED:

125680323

MYI:	110452410 110452415 110456550 110456553

PMAX:

117329305 117329306 117329839 117329841

MMER:

123557088 123557153

RPHI:

132718310 132729245 132758356

OBI:	106872238 106883106

OSN:	115213952 115228066

LAK:

106181082

NVE:	5512961 5512969

EPA:

110238851

ATEN:

116304526 116304527

ADF:

107331264

AMIL:

114977512

PDAM:

113667155

SPIS:

111327304

DGT:

114532928

XEN:

124440925

HMG:

101240720

HSY:

130657730

» show all

Reference

1 [PMID:19506037]

Authors

Vacaru AM, Tafesse FG, Ternes P, Kondylis V, Hermansson M, Brouwers JF, Somerharju P, Rabouille C, Holthuis JC

Title

Sphingomyelin synthase-related protein SMSr controls ceramide homeostasis in the ER.

Journal

J Cell Biol 185:1013-27 (2009)
DOI:10.1083/jcb.200903152

Reference

2 [PMID:23449981]

Authors

Vacaru AM, van den Dikkenberg J, Ternes P, Holthuis JC.

Title

Ceramide phosphoethanolamine biosynthesis in Drosophila is mediated by a unique ethanolamine phosphotransferase in the Golgi lumen.

Journal

J Biol Chem 288:11520-30 (2013)
DOI:10.1074/jbc.M113.460972

Sequence

[dme:Dmel_CG4585]

Other DBs

ExplorEnz - The Enzyme Database:

2.7.8.48

IUBMB Enzyme Nomenclature:

2.7.8.48

ExPASy - ENZYME nomenclature database:

2.7.8.48

BRENDA, the Enzyme Database:

2.7.8.48

DBGET integrated database retrieval system