KEGG   ENZYME: 2.7.99.1
Entry
EC 2.7.99.1                 Enzyme                                 
Name
triphosphate---protein phosphotransferase;
diphosphate:microsomal-membrane-protein O-phosphotransferase (erroneous);
DiPPT (erroneous);
pyrophosphate:protein phosphotransferase (erroneous);
diphosphate---protein phosphotransferase (erroneous);
diphosphate:[microsomal-membrane-protein] O-phosphotransferase (erroneous)
Class
Transferases;
Transferring phosphorus-containing groups;
Other protein kinases
Sysname
triphosphate:[microsomal-membrane-protein] phosphotransferase
Reaction(IUBMB)
triphosphate + [microsomal-membrane protein] = diphosphate + phospho-[microsomal-membrane protein] [RN:R04312]
Reaction(KEGG)
R04312
Substrate
triphosphate [CPD:C00536];
microsomal-membrane protein [CPD:C03788]
Product
diphosphate [CPD:C00013];
phospho-[microsomal-membrane protein]
Comment
This enzyme was originally thought to use diphosphate as substrate [1] but this has since been disproved [2]. The activity is observed as the second part of a biphasic reaction after depletion of ATP. Tripolyphosphate is a contaminant of [gamma-32P]ATP.
History
EC 2.7.99.1 created 1983 as EC 2.7.1.104, transferred 2005 to EC 2.7.99.1
Reference
1  [PMID:6246514]
  Authors
Lam KS, Kasper CB.
  Title
Pyrophosphate:protein phosphotransferase: a membrane-bound enzyme of endoplasmic reticulum.
  Journal
Proc Natl Acad Sci U S A 77:1927-31 (1980)
DOI:10.1073/pnas.77.4.1927
Reference
2  [PMID:3949741]
  Authors
Tsutsui K.
  Title
Tripolyphosphate is an alternative phosphodonor of the selective protein phosphorylation of liver microsomal membrane.
  Journal
J Biol Chem 261:2645-53 (1986)
Other DBs
ExplorEnz - The Enzyme Database: 2.7.99.1
IUBMB Enzyme Nomenclature: 2.7.99.1
ExPASy - ENZYME nomenclature database: 2.7.99.1
BRENDA, the Enzyme Database: 2.7.99.1
CAS: 74092-32-3

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Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Protein sequence (6)   
   PDBSTR (6)   
3D Structure (1)   
   PDB (1)   
All databases (13)   

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