KEGG   ENZYME: 2.8.1.16
Entry
EC 2.8.1.16                 Enzyme                                 
Name
L-aspartate semialdehyde sulfurtransferase;
MA1821 (locus name);
MJ0100 (locus name)
Class
Transferases;
Transferring sulfur-containing groups;
Sulfurtransferases
Sysname
hydrogen sulfide:L-aspartate-4-semialdehyde sulfurtransferase
Reaction(IUBMB)
hydrogen sulfide + L-aspartate 4-semialdehyde + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ = L-homocysteine + H2O + 2 oxidized ferredoxin [iron-sulfur] cluster [RN:R12505]
Reaction(KEGG)
R12505
Substrate
hydrogen sulfide [CPD:C00283];
L-aspartate 4-semialdehyde [CPD:C00441];
reduced ferredoxin [iron-sulfur] cluster [CPD:C00138];
H+ [CPD:C00080]
Product
L-homocysteine [CPD:C00155];
H2O [CPD:C00001];
oxidized ferredoxin [iron-sulfur] cluster [CPD:C00139]
Comment
The enzyme, characterized from the archaeon Methanosarcina acetivorans, participates in an L-methionine biosysnthetic pathway found in most of the methanogenic archaea.
History
EC 2.8.1.16 created 2019
Pathway
ec00270  Cysteine and methionine metabolism
ec01100  Metabolic pathways
Orthology
K23975  L-aspartate semialdehyde sulfurtransferase
Genes
HMR: Hipma_0164
DAV: DESACE_02220
DFL: DFE_2712
PSYF: N1030_16530
DSB: LN040_15305
DMA: DMR_46290
DCB: C3Y92_19940
DGG: DGI_1165
DDE: Dde_3007
DMS: E8L03_15160
DSA: Desal_3782
DHY: DESAM_20787
DAF: Desaf_1190
DAS: Daes_3322
DPI: BN4_12199
DEJ: AWY79_02770
PPRF: DPRO_1935
PSEL: GM415_05005
DDN: DND132_2281
PSEF: PSDVSF_22760
PPOR: JCM14722_18180
PNW: SYK_23440
PTHE: LF599_00085
DSX: GD604_18225
DSD: GD606_13500
PBIZ: LWC08_11720
DVU: DVU_2938
DVL: Dvul_0430
DVM: DvMF_1464
DVG: Deval_2713
CLIH: KPS_001748
TMUR: JBF11_09500
DBA: Dbac_3098
DESU: NLA06_15430
THEW: TDMWS_05980
DRT: Dret_2469
DSF: UWK_02633
DLM: DPPLL_15440
DPR: Despr_3243
DOG: HP555_05040
DBK: DGMP_14500
DDU: GF1_17180
ECOM: QTN59_05140
DAL: Dalk_1368
DAT: HRM2_27800
DTO: TOL2_C21940
DOV: DSCO28_01030
DWD: DSCW_12590
DALK: DSCA_04730
DML: Dmul_10250
DLI: dnl_08380
DMM: dnm_024620
DEK: DSLASN_02770
SAT: SYN_01778
DAO: Desac_0386
DTI: Desti_2525
SFU: Sfum_1059
DAX: FDQ92_09500
DBR: Deba_3156
DMP: FAK_14090
TID: Thein_1355
TOP: TOPB45_0044
TCM: HL41_05065
THET: F1847_01765
CTHI: THC_0177
TAV: G4V39_02840
TMAI: FVE67_05875
DHR: LGS26_07215
CRS: FQB35_11345
SWO: Swol_1441
SLP: Slip_0735
DOR: Desor_0315
DAI: Desaci_0590
DMI: Desmer_0317
DCA: Desca_0089
PTH: PTH_1472
DRM: Dred_0101
DRU: Desru_0171
DFG: B0537_01265
DAE: Dtox_3584
DKU: Desku_1645
DAU: Daud_0911
TFR: BR63_10460
FWA: DCMF_03305
TJR: TherJR_1173
DGI: Desgi_2433
ELM: ELI_3644
EMT: CPZ25_018535
ELIM: B2M23_08225
AWO: Awo_c28040
AWI: CHL1_000701
ALKA: J0B03_00425
CSPO: QNI18_01750
ADG: Adeg_1432
TPZ: Tph_c18160
TEP: TepRe1_2592
TAE: TepiRe1_2794
HALS: D7D81_00205
IFN: GM661_16200
KME: H0A61_00691
HPRF: HLPR_19650
CALK: HUE98_00810
SYN: slr0689
SYZ: MYO_14070
SYY: SYNGTS_0403(slr0689)
SYT: SYNGTI_0403(slr0689)
SYS: SYNPCCN_0403(slr0689)
SYQ: SYNPCCP_0403(slr0689)
SYJ: D082_06630
SYO: C7I86_02090
SYC: syc1103_c
SYU: M744_00900
SYF: Synpcc7942_0414
SYR: SynRCC307_0741
CYA: CYA_1941
CYB: CYB_0133
SYNE: Syn6312_3160
SYNP: Syn7502_00796
SYNC: CB0101_13020
DSL: Dacsa_1741
CGC: Cyagr_3295
CYI: CBM981_1238
WNA: KA717_19995
CMP: Cha6605_4919
CYN: Cyan7425_0812
CEP: Cri9333_1242
TVN: NIES2134_103410
SLW: BRW62_11990
AMR: AM1_4338
TEL: tll2362
THN: NK55_08785
THEC: FFX45_06715
TSZ: OOK60_15975
LEN: LEP3755_12480
LET: O77CONTIG1_03371
LBO: LBWT_38250
KOV: K9N68_18600
LSC: KIK02_03005
LSK: J5X98_24355
HHG: XM38_043210
PSEU: Pse7367_2607
PSER: ABRG53_1141
PGX: OA858_05925
THEU: HPC62_06500
TOG: HNI00_10640
TSIN: OXH18_12005
GLP: Glo7428_2384
CHON: NIES4102_17580
GDU: P0S91_03735
GEN: GM3709_1191
GEE: GM3708_3030
CAN: Cyan10605_3460
CSN: Cyast_0235
CYL: AA637_05905
SYP: SYNPCC7002_A0581
SYV: AWQ23_03070
SYL: AWQ21_03040
LEP: Lepto7376_4246
SYNN: NIES970_03150
MAR: MAE_17670
MPK: VL20_3116
MIQ: B5D77_16555
MVZ: myaer102_50970
HAO: PCC7418_0404
ENN: FRE64_14180
CYT: cce_2273
CWA: CwatDRAFT_3992
CYP: PCC8801_2541
CYH: Cyan8802_3565
CYC: PCC7424_5211
CYJ: Cyan7822_1085
TER: Tery_2393
ARP: NIES39_C02980
PAGH: NIES204_23590
PPSU: NO713_03154
PRUN: PCC7821_02841
OXY: HCG48_20610
MVAG: D0A34_06710
LFS: HFV01_11580
OAC: Oscil6304_3994
ONI: Osc7112_0745
MPRO: BJP34_25695
PHOR: JWS08_20780
PYH: NEA10_12555
MIC: Mic7113_6125
GEI: GEI7407_3368
GVI: glr3673
GLJ: GKIL_0338
GML: ISF26_18310
ANA: all1701
NPU: Npun_F2759
NOS: Nos7107_1988
NOP: Nos7524_2333
NON: NOS3756_00480
NFL: COO91_04664
NOE: CLI64_09945
NSH: GXM_04842
NED: HUN01_20545
NPZ: ACX27_23525
AVA: Ava_0664
NAZ: Aazo_2809
ANB: ANA_C20754
ACY: Anacy_2710
AWA: AA650_18190
ANN: EH233_29085
CSG: Cylst_3583
RSIN: B6N60_03724
HBQ: QI031_19890
CALO: Cal7507_3004
CALT: Cal6303_4507
CALH: IJ00_20895
CALN: NIES2098_63950
CALS: NIES3974_18430
RIV: Riv7116_1289
FIS: FIS3754_48300
NSPH: BDGGKGIB_02331
DOU: BMF77_03441
DFS: HGD76_03375
DHT: NG743_07150
CCUR: IAR63_07475
CRK: L3I90_07915
AFLO: HEQ12_02920
STOQ: K2F26_13650
AEE: IM676_09535
RCS: NIES932_05320
TOQ: HCG51_08075
ALAX: NIES50_38630
NCN: BZZ01_28855
CTHE: Chro_2043
PLP: Ple7327_0717
SCS: Sta7437_2930
STAN: STA3757_20740
GLT: GlitD10_2770
GCY: LQF76_10780
CEO: ETSB_1648
CER: RGRSB_1363
CEEC: P3F56_08435
DET: DET0921
DEH: cbdbA872
DEB: DehaBAV1_0805
DEV: DhcVS_792
DEG: DehalGT_0766
DMC: btf_817
DMD: dcmb_855
DMG: GY50_0800
DMX: X792_04160
DMY: X793_04330
DMZ: X794_03960
DUC: UCH007_07530
DEW: DGWBC_0778
DFO: Dform_00758
DETH: HX448_05545
TNR: Thena_0230
TACI: TDSAC_0221
SSM: Spirs_1309
OCK: EXM22_00480
SBU: SpiBuddy_0032
SGP: SpiGrapes_1889
SASS: MUG09_00165
SCD: Spica_1547
BHC: JFL75_11025
OSP: Odosp_3419
BUY: D8S85_03050
BVIR: I6J59_10590
BFH: F1611_05050
ACOU: A5CBH24_17170
DORI: FH5T_06660
DRC: G0Q07_00095
MCOS: GM418_14080
ANF: AQPE_2027
TAM: Theam_1635
DTE: Dester_1534
TTK: TST_1097 TST_1600
TLE: Tlet_1363
TTA: Theth_0529
PHY: AJ81_01635
TME: Tmel_0733
TAF: THA_1098
TFE: JYK00_07385
FNO: Fnod_1281
FPE: Ferpe_1660
FIA: NA23_08215
FRR: IB67_03255
OCY: OSSY52_04190
OCS: OF820_01045
CPO: COPRO5265_0016
DTH: DICTH_0569
DTU: Dtur_0732
ALAM: RT761_01519
MJA: MJ_0100
MFE: Mefer_0355
MVU: Metvu_0926
MFS: MFS40622_1018
MIF: Metin_0262
MJH: JH146_0779
MESG: MLAUSG7_0883
MESA: MLASG1_0976
MIG: Metig_0741 Metig_1786
MMP: MMP1359
MMQ: MmarC5_0219
MMX: MmarC6_1314
MMZ: MmarC7_0604
MMD: GYY_07625
MMAK: MMKA1_15830
MMAO: MMOS7_14640
MMAD: MMJJ_14800(guaB_5)
MAE: Maeo_0793
MVN: Mevan_0669
MVO: Mvol_1031
MOK: Metok_0495
METF: CFE53_04920
MTH: MTH_855
MMG: MTBMA_c12520
MWO: MWSIV6_1231
MTEE: MTTB_05240
METC: MTCT_0768
METE: tca_00822
METZ: METMT2_0925
METK: FVF72_07270
MTHM: FZP57_05850
METJ: FZP68_00355
MSI: Msm_0085
MEB: Abm4_0692
MMIL: sm9_0981
MEYE: TL18_05465
MOL: YLM1_0877
MEL: Metbo_1965
MEW: MSWAN_0653
METH: MBMB1_0672
MFC: BRM9_1523
MFI: DSM1535_2225
MCUB: MCBB_0683
MSUB: BK009_01590
METN: BK008_09335
METT: CIT01_02115
METO: CIT02_03405
MEME: HYG87_03580
MFEG: GCM10025860_17380
MFV: Mfer_1260
MKA: MK0907
AFU: AF_1186
AFG: AFULGI_00012860
APO: Arcpr_1399
AVE: Arcve_1085
AST: Asulf_01823
FPL: Ferp_1951
GAC: GACE_0621
GAH: GAH_01959
MBA: Mbar_A2085
MBY: MSBRM_2423
MBW: MSBRW_2654
MBAR: MSBR2_2388
MBAK: MSBR3_2445
MAC: MA_1821
MMA: MM_0241
MMAZ: MmTuc01_0248
MMJ: MSMAS_1060
MMAC: MSMAC_2424
MVC: MSVAZ_1104
MEK: MSKOL_1059
MLS: MSLAZ_2048
METM: MSMTP_1092
MEF: MSWH1_1180
MEQ: MSWHS_1256
MSJ: MSSAC_2171
MSZ: MSSIH_1745
MSW: MSSIT_1805
MTHR: MSTHT_0029
MTHE: MSTHC_0699
MHOR: MSHOH_1266
MFZ: AOB57_002390
MBU: Mbur_0311
MMET: MCMEM_0825
MELO: J7W08_02345
MMH: Mmah_1251
MHAZ: BHR79_07280
MPOT: BKM01_03525
MEV: Metev_1059
MZH: Mzhil_0894
MPY: Mpsy_0868
MZI: HWN40_04325
MMAV: RE476_05965
MSEB: RE474_02390
MHZ: Metho_0925
MEHF: MmiHf6_05210(impDH_1)
MEES: MmiEs2_04710(impDH_2)
MTP: Mthe_0019
MCJ: MCON_1340
MHI: Mhar_2345
MHU: Mhun_0138
MRTJ: KHC33_13525
MLA: Mlab_0451
MEM: Memar_1517
MBG: BN140_1854
MEMA: MMAB1_2385
MCHK: MchiMG62_16830
MSUM: OH143_01795
MRC: R6Y96_08075
MPI: Mpet_1603
MEND: L6E24_01840
MEFW: F1737_03820
MAQE: RJ40_00260
MFK: E2N92_02115
MOU: OU421_01020
MESB: L1S32_01980
MANQ: L1994_05340
MBN: Mboo_1272
MFO: Metfor_2035
MPL: Mpal_1290
MPD: MCP_0132
MEZ: Mtc_0355
RCI: RCIX1241
MELU: MTLP_06200
MER: MMINT_14480
MARC: AR505_0724
BARB: AOA66_0665(guaB_3)
FLT: Sv326_0760
LOKI: Lokiarch_29370
 » show all
Reference
1  [PMID:25315403]
  Authors
Rauch BJ, Gustafson A, Perona JJ
  Title
Novel proteins for homocysteine biosynthesis in anaerobic microorganisms.
  Journal
Mol Microbiol 94:1330-42 (2014)
DOI:10.1111/mmi.12832
  Sequence
[mac:MA_1821 MA_1822]
Reference
2  [PMID:25938369]
  Authors
Allen KD, Miller DV, Rauch BJ, Perona JJ, White RH
  Title
Homocysteine is biosynthesized from aspartate semialdehyde and hydrogen sulfide in methanogenic archaea.
  Journal
Biochemistry 54:3129-32 (2015)
DOI:10.1021/acs.biochem.5b00118
  Sequence
[mja:MJ_0100 MJ_0099]
Other DBs
ExplorEnz - The Enzyme Database: 2.8.1.16
IUBMB Enzyme Nomenclature: 2.8.1.16
ExPASy - ENZYME nomenclature database: 2.8.1.16
BRENDA, the Enzyme Database: 2.8.1.16

  All links  
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (7)   
   KEGG COMPOUND (7)   
Chemical reaction (3)   
   KEGG REACTION (1)   
   KEGG RCLASS (2)   
Gene (915)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (419)   
   KEGG MGENES (495)   
Protein sequence (5)   
   UniProt (3)   
   SWISS-PROT (2)   
DNA sequence (8)   
   GenBank (5)   
   EMBL (3)   
Protein domain (6)   
   InterPro (6)   
All databases (948)   

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