KEGG ENZYME: 2.8.2.22

ENZYME: 2.8.2.22

Entry

EC 2.8.2.22                 Enzyme

Name

aryl-sulfate sulfotransferase;
arylsulfate-phenol sulfotransferase;
arylsulfotransferase (ambiguous);
ASST;
arylsulfate sulfotransferase;
arylsulfate:phenol sulfotransferase;
astA (gene name);
aryl-sulfate:phenol sulfotransferase

Class

Transferases;
Transferring sulfur-containing groups;
Sulfotransferases

Sysname

aryl-sulfate:phenol sulfonotransferase

Reaction(IUBMB)

an aryl sulfate + a phenol = a phenol + an aryl sulfate

Reaction(KEGG)

(other) R02996

Substrate

aryl sulfate [CPD:C00850];
phenol [CPD:C15584]

Product

phenol [CPD:C15584];
aryl sulfate [CPD:C00850]

Comment

The enzyme, characterized from bacteria that colonize the human and mouse intestine, catalyses the transfer of a sulfate group from a phenol sulfate ester to other phenolic compounds. Activity is enhanced by Mg2+ and Mn2+ [1]. Unlike EC 2.8.2.9, tyrosine-ester sulfotransferase and EC 2.8.2.1, aryl sulfotransferase, the enzyme does not act on 3'-phosphoadenylyl sulfate or adenosine 3',5'-bisphosphate [1].The level of sulfation of polyphenols depends on the positions of the hydroxyl groups [3-5]. Hydroxy groups of tyrosine residues in peptides such as angiotensin can also act as acceptors [2]. The reaction proceeds according to a ping pong bi bi mechanism [6].

History

EC 2.8.2.22 created 1990

Orthology

K01023

arylsulfate sulfotransferase

Genes

ECG:	E2348C_3334

ECP:

ECP_3130

ENA:	ECNA114_3129(asst)

ECOS:

EC958_3441(assT)

ECV:	APECO1_3375(assT)

ECM:	EcSMS35_3333

ECQ:	ECED1_3704(assT)

EUM:	ECUMN_3523(assT)

ECI:	UTI89_C3473(asst)

EIH:	ECOK1_3467

ECZ:	ECS88_3432(assT)

ECC:	c3785(asst)

ELO:	EC042_3329(assT)

ELN:	NRG857_15125

ESE:

ECSF_2880

EAB:	ECABU_c34540

ELU:	UM146_01115

ELC:	i14_3479(asst)

ELD:	i02_3479(asst)

ELF:

LF82_506

ECOI:

ECOPMV1_03352

ECOJ:

P423_17180

EFE:	EFER_2980(assT) EFER_3637

EAL:	EAKF1_ch2891c

EMA:	C1192_20305

ESZ:	FEM44_06260

ERUY:

OSH18_16405

STY:	STY3370(assT) STY3579

STT:	t3112(assT) t3317

SEX:	STBHUCCB_32900 STBHUCCB_35050

SENT:

TY21A_15755 TY21A_16810 TY21A_17775

STM:	STM3191 STM4098

SEO:	STM14_3866 STM14_4926

SEV:	STMMW_31521 STMMW_39511 STMMW_40631

SEY:	SL1344_3165(assT) SL1344_3934 SL1344_4047

SEM:	STMDT12_C32480 STMDT12_C41310 STMDT12_C42450

SEJ:	STMUK_3181 STMUK_3965 STMUK_4083

SEB:	STM474_3346 STM474_4159 STM474_4281

SEF:	UMN798_3471(assT) UMN798_4319 UMN798_4442

SETU:

STU288_16165 STU288_20640

SETC:

CFSAN001921_01050 CFSAN001921_19925 CFSAN001921_20525

SENR:

STMDT2_30851(assT) STMDT2_38481 STMDT2_39611

SEND:

DT104_39941 DT104_41071

SENI:

CY43_16635 CY43_20825 CY43_21425

SEEN:

SE451236_00395 SE451236_00995 SE451236_22085

SPT:	SPA3060(assT) SPA3941

SEK:	SSPA2856 SSPA3668

SPQ:	SPAB_03985 SPAB_04937 SPAB_05076

SEI:	SPC_3266(assT) SPC_4088 SPC_4206

SEC:	SCH_3136(astJ) SCH_3878 SCH_3989

SEH:	SeHA_C3443 SeHA_C4307 SeHA_C4430

SHB:

SU5_089

SENH:

CFSAN002069_11575 CFSAN002069_12155 CFSAN002069_16180

SEEH:

SEEH1578_02105 SEEH1578_05985 SEEH1578_06755

SEE:	SNSL254_A3450 SNSL254_A4260 SNSL254_A4429

SENN:

SN31241_43220 SN31241_45890 SN31241_47480

SEW:	SeSA_A3378 SeSA_A4188 SeSA_A4314

SEA:	SeAg_B3373 SeAg_B4211 SeAg_B4344

SENS:

Q786_15545 Q786_19515 Q786_20120

SED:	SeD_A3545 SeD_A4367 SeD_A4498

SEG:	SG3088 SG3322 SG3471

SEL:	SPUL_3203 SPUL_3451 SPUL_3564

SEGA:

SPUCDC_3189 SPUCDC_3437 SPUCDC_3550

SET:	SEN3034 SEN3775 SEN3888

SENA:

AU38_15435 AU38_19515 AU38_20095

SENO:

AU37_15440 AU37_19510 AU37_20110

SENV:

AU39_15440 AU39_19530 AU39_20130

SENQ:

AU40_17395 AU40_21775 AU40_22460

SENL:

IY59_16040 IY59_19985 IY59_20590

SENJ:

CFSAN001992_13200 CFSAN001992_13780 CFSAN001992_17575

SEEC:

CFSAN002050_02785 CFSAN002050_03330 CFSAN002050_22935

SEEB:

SEEB0189_003910 SEEB0189_021855 SEEB0189_022440

SEEP:

I137_15285 I137_17130

SENB:

BN855_32720 BN855_40520 BN855_41750

SENE:

IA1_15430 IA1_19345 IA1_19940

SENC:

SEET0819_03740 SEET0819_04335 SEET0819_22970

SES:	SARI_03956 SARI_04436

SBG:	SBG_0038 SBG_0782

SBZ:	A464_3223 A464_39 A464_848

SBV:	N643_00180 N643_03870 N643_13875

SALZ:

EOS98_03355 EOS98_21820 EOS98_22425

ECLZ:

LI64_00125

ECLO:

ENC_41780

ENT:	Ent638_1509

ENX:	NI40_007005

LNI:	CWR52_20735

CCON:

AFK62_12290

CDM:	AFK67_07535

CMW:	AFK63_11320

CRO:	ROD_35871(assT)

CWE:	CO701_01305

CYO:	CD187_03650

CPOT:

FOB25_14985

CAF:	AL524_09350

CIF:	AL515_19805

CIR:	C2U53_29110

CPAR:

CUC49_15730

CITZ:

E4Z61_20470

CIX:	M4I31_03555

CIB:	HF677_003240

CEN:	LH86_00760

KAS:	KATP_00190

LEI:	C2U54_04965

LEA:	GNG26_00095

LEY:	DVA43_17780

AHN:	NCTC12129_04856

PSGC:

G163CM_35260 G163CM_42680(assT)

EIC:	NT01EI_0602

ETR:	ETAE_0524(assT)

ETD:

ETAF_0475

ETE:

ETEE_2284

ETC:	ETAC_02545

EDW:	QY76_00280

EDL:	AAZ33_02465

EHO:	A9798_13880

LRI:	NCTC12151_01683 NCTC12151_02903 NCTC12151_03505

PGH:	FH974_16730

PPG:	PputGB1_0236

PPW:	PputW619_5000

PPUH:

B479_01490

PPUT:

L483_00795

PPUN:

PP4_02300

PMOL:

CLJ08_11780

PIX:	RIN61_12830

PMOS:

O165_022200

PEN:

PSEEN0187

PSEC:

CCOS191_0184(assT)

PXA:	KSS93_03125

PXN:	HU772_000940

PFAK:

KSS94_25945

PMUY:

KSS95_02210

PMAM:

KSS90_00920

PORY:

EJA05_27160

PTW:	TUM18999_58740

PSIH:

LOY51_25975

PKM:	PZ739_01020

PKK:	QQ992_00895

AVN:	Avin_08230

AVL:	AvCA_08230

AVD:	AvCA6_08230

SON:	SO_3872(assT)

SSE:	Ssed_0237 Ssed_4001

SPL:	Spea_1584 Spea_4022 Spea_4027

SHL:	Shal_0231 Shal_0236 Shal_1652

SWD:

Swoo_1752

SWP:

swp_4147

SJA:	SJ2017_1305

SCAA:

TUM17387_30510(assT)

SEUR:

FM038_003455 FM038_007065 FM038_022130 FM038_024685

SYK:	KDN34_16710

SCHK:

GII14_17390

SACH:

K0H61_16950

SPSJ:

K0I62_04825

FBL:

Fbal_0078

FES:	HER31_00965 HER31_02125 HER31_04565 HER31_09195 HER31_11605 HER31_12540 HER31_12585 HER31_14280 HER31_14730 HER31_15215 HER31_15250 HER31_15265 HER31_15290 HER31_15340 HER31_16180

MII:	BTJ40_19675

MICT:

FIU95_18450(assT)

ATEP:

Atep_00940

AAJ:	BOQ57_02105

AMED:

B224_6011

ARV:	C7N77_02410

ARIV:

KYK33_01720

RGE:

RGE_17750

MTIM:

DIR46_02970

SUTT:

SUTMEG_06630 SUTMEG_06740 SUTMEG_07190 SUTMEG_08390 SUTMEG_08590 SUTMEG_08610 SUTMEG_10500 SUTMEG_14160 SUTMEG_16630 SUTMEG_17370 SUTMEG_19330 SUTMEG_20600

SUTK:

FG381_00315 FG381_00545 FG381_01165 FG381_01255 FG381_02545 FG381_03410 FG381_06585 FG381_10695 FG381_10770

SWS:	I6J16_02505 I6J16_03380 I6J16_03820 I6J16_03960 I6J16_04290 I6J16_04300 I6J16_04510 I6J16_05055 I6J16_05825 I6J16_07180 I6J16_07565 I6J16_07835 I6J16_08315 I6J16_11910

BEB:	AEM42_02870

HBC:	AEM38_03200

NOT:	C7W88_16305

SLAA:

EUU25_08765

CJJ:	CJJ81176_0882

CJU:

C8J_0813

CJN:	ICDCCJ07001_830

CJM:	CJM1_0839(astA)

CJV:	MTVDSCj20_0871

CJY:	QZ67_00935(assT)

CJQ:	UC78_0827(assT_1)

CJX:	BN867_08620

CFF:	CFF8240_0436

CFT:	CFF04554_0434(astA)

CFV:	CFVI03293_0433(astA)

CFX:	CFV97608_0436(astA)

CFZ:

CSG_5150

CAMP:

CFT03427_0445(astA)

CFP:	CR44_02240

CCV:	CCV52592_0844(astA1) CCV52592_1148(astA2) CCV52592_1149(astA3)

CCO:	CCC13826_0231(astA1) CCC13826_0901(astA2)

CCOC:

CCON33237_0098(astA1) CCON33237_1797(astA2)

CLA:	CLA_0560(astA)

CLR:	UPTC16701_0560(astA)

CLM:	UPTC16712_0566(astA)

CLQ:	UPTC4110_0568(astA)

CLN:	UPTC3659_0594(astA1) UPTC3659_0595(astA2)

CLL:	CONCH_0566(astA)

CIS:	CINS_0482(astA)

CVO:	CVOL_0497(astA)

CPEL:

CPEL_0515(astA)

CAMR:

CAQ16704_0592(astA1) CAQ16704_0593(astA2)

CSM:	CSUB8521_0597(astA)

CSF:	CSUB8523_0584(astA)

CGRA:

CGRAC_2066 CGRAC_2074(assT)

CURE:

CUREO_0090 CUREO_0091 CUREO_0092

CSPF:

CSF_0054(astA1) CSF_0055(astA2) CSF_0056(astA3) CSF_0057(astA4) CSF_0468(astA5)

CPIN:

CPIN18020_0377(astA1) CPIN18020_0597(astA2)

COJ:	CORN_0581(astA)

CRX:	CRECT_2203(astA1) CRECT_2211(astA2)

CGEO:

CGEO_0082(astA1) CGEO_0083(astA2) CGEO_1484(astA3)

CBLA:

CBLAS_1637(astA1) CBLAS_1805(astA2)

CCOR:

CCORG_0423(astA1) CCORG_0424(astA2) CCORG_0425(astA3) CCORG_0426(astA4)

CARM:

CARM_0565(astA)

CSHO:

CSHOW_0176(astA1) CSHOW_0183(astA2)

CNV:	CNZW441b_0765(astA)

SMUL:

SMUL_0054(assT)

SHAL:

SHALO_0031

HEBR:

AEBR_0712(astA1) AEBR_2662(astA2)

GSK:	KN400_3060

GME:

Gmet_1382

GEM:

GM21_1436

GEO:

Geob_2732

TAMM:

GEAMG1_1920(assT)

GBN:	GEOBRER4_14410

GSUB:

KP001_12990

GSB:	GSUB_01485

DEP:

AOP6_2629

DMS:	E8L03_13135

PBIZ:

LWC08_12360

DPR:	Despr_1642

DEO:	CAY53_02860

DOG:	HP555_04320

BEO:

BEH_12040

HNZ:	P9989_16890

HAMY:

MUO15_17995

VIR:	X953_17070

VHL:	BME96_16560

VIL:	CFK37_00285

VNE:	CFK40_16195

VIM:	GWK91_11265

LAO:	AOX59_14605 AOX59_15905

BOU:	I5818_22545

FAF:	OE104_11575

SHV:	AAT16_01965

NAMP:

KPF49_00255

NMY:	CJ229_006465

LSG:	lse_1957(astA)

LIV:

LIV_1951

LII:	JL52_10270

LIW:	AX25_10435

LIA:	JL58_10460

LIO:	JL53_10930

VIJ:	JNUCC6_13850

LHD:

HUO_04080

LAI:	LAC30SC_08330

LAY:	LAB52_07760

LKE:

WANG_0248

LPL:	lp_1381(astA)

LPJ:	JDM1_1159(astA)

LPT:	zj316_1433(astA)

LPS:	LPST_C1109(astA)

LPR:	LBP_cg1052

LPZ:

Lp16_1060

LPB:	SH83_05730

LPX:	ASU28_05630

LPG:	BB562_10405

LARG:

LPA65_05500

LMU:	LBLM1_03830

LNG:	BSQ50_03935

LBR:	LVIS_0405 LVIS_2143

LBK:	LVISKB_0416 LVISKB_2203

LKO:	ABN16_02825 ABN16_04120

LZY:	LZ3411_0180

LSUA:

H3M12_04325 H3M12_05150

LNA:	RIN67_11105 RIN67_12130

LAGL:

BEN83_08330

LACA:

LAC1533_2290

LBT:	AYR52_00910

LCY:	LC20004_11875

LMAE:

FGL90_02895 FGL90_02900

PACI:

A4V11_07050

PIO:	PI20285_08415

LGN:	ABM34_11400

LALW:

BTM29_05890

LALI:

LA20249_06520

LFM:	LF20184_08670

LFT:	FG051_08460

CPAB:

G6534_03175

LSA:

LCA_0090

LGM:	LG542_08745

LAH:	LA20533_04605

LDX:	LH506_01230

WJO:	FOL01_0406

WPA:	CO680_06160

WHE:	EFA59_01920

EAV:	EH197_05885

ECEC:

NCTC12421_01260

ERAF:

J9537_17180

AUR:	HMPREF9243_0620 HMPREF9243_1609

AUN:	AWM73_01900 AWM73_06485

ACG:	AWM71_03515

ALOY:

CJ190_002065

AMIT:

DBT49_0002515

ATJ:	DBT50_001840 DBT50_008210 DBT50_008215

CLT:	CM240_1051

FPLA:

A4U99_08695

ACOL:

K5I23_03990

DSY:	DSY0226 DSY1457 DSY2571

DHD:	Dhaf_0171 Dhaf_3734

DDH:	Desde_0143 Desde_2126 Desde_3219

DDL:	Desdi_0387 Desdi_2195 Desdi_2623 Desdi_3428

DOR:	Desor_1828 Desor_3930 Desor_4965

DAI:	Desaci_3392

DMI:	Desmer_1264 Desmer_1906

DFG:	B0537_02840 B0537_14460

ELM:

ELI_4422

EMT:	CPZ25_012525

ELIM:

B2M23_02440

ALKA:

J0B03_01585

ROB:	CK5_20920 CK5_20930

CPY:

Cphy_3285

CSCI:

HDCHBGLK_00212

CHYL:

CE91St63_07810

BPRL:

CL2_18210

ARF:	AR1Y2_1265 AR1Y2_1266

ACAC:

EYQ97_11040

DLO:	K5I24_05260

SINT:

K5I26_02320

CBIL:

EUBC25_17220

AARG:

Aargi30884_23650

ABSI:

A9CBEGH2_21100

ERB:	A4V01_02480

TUR:	AT726_00790 AT726_11785

TSG:	HLK68_11980 HLK68_13645

TBB:	J0J69_01840 J0J69_03320

FIT:	Fi14EGH31_01720

CIU:	G4D55_00755

ERM:	EYR00_04000

MBJ:	KQ51_01780(assT)

KRS:	EQG70_00425

BRX:	BH708_14085

BSAU:

DWV08_14830

AACI:

ASQ49_04305

BLJ:

BLD_0063

BLF:

BLIF_1444

BLG:

BIL_01140

BLZ:	BLGT_07485

BDE:

BDP_1333

BDN:

BBDE_1271

BCAT:

BBCT_1065

BANG:

BBAG_0512

BPSC:

BBPC_1067

BSCA:

BBSC_1060

BGX:	ESN35_07120

BLEM:

BL8807_07825

BEU:	BE0216_03215

SIJ:

SCIP_0304

PDO:

PSDT_1202

AYM:	YM304_39250

PPHT:

GA004_09905

AHEL:

Q31a_02720(assT)

TPOL:

Mal48_14220(assT_1)

PBU:	L21SP3_01066(assT)

PBP:	STSP1_01607(assT)

BHY:	BHWA1_01792

BHD:	BHYOB78_07110

BRM:	Bmur_1462 Bmur_1825

BPO:	BP951000_1092

BPJ:	B2904_orf247 B2904_orf502

BPIP:

BPP43_09595

BPW:

WESB_2441

BIP:

Bint_2909

BHP:	BHAMNSH16_07205

ABA:	Acid345_1756

ACA:	ACP_1671 ACP_3365

ABAS:

ACPOL_3964

SUS:

Acid_2872

FVA:	FV113G1_07730 FV113G1_10570

FUL:	C4N20_11400

FMO:	C4N19_08175

CSOM:

MKD34_08850

BVU:

BVU_0583

PGOL:

K6V26_19365

POC:	NCTC13071_01100

MCOS:

GM418_15250

NSO:	NIASO_15775

PGIN:

FRZ67_04340

PEP:	AQ505_04035

PSTY:

BFS30_03955

PGS:	CPT03_00665

PROE:

H9L23_18370

PGJ:	QG516_10865

SPHN:

BV902_08935 BV902_25995

SPHE:

GFH32_17925

SPDR:

G6053_27945

SSPI:

I6J01_08670

SSIY:

JVX97_05325

MUH:	HYN43_010290

MGK:	FSB76_29340

MGOS:

DIU38_013485

OLI:	FKG96_00205

SBX:	CA265_17045

SOQ:	LQ777_04600

HYP:	A0257_01630

HYZ:	AXW84_09550

FJG:	BB050_00264

FBC:	FB2170_04585

CAO:	Celal_3865

MUR:	EQY75_02610

» show all

Reference

1 [PMID:3460636]

Authors

Kim DH, Konishi L, Kobashi K.

Title

Purification, characterization and reaction mechanism of novel arylsulfotransferase obtained from an anaerobic bacterium of human intestine.

Journal

Biochim Biophys Acta 872:33-41 (1986)
DOI:10.1016/0167-4838(86)90144-5

Reference

Authors

Kobashi, K., Kim, D.-H. and Morikawa, T.

Title

A novel type of arylsulfotransferase.

Journal

J Protein Chem 6:237-244 (1987)

Reference

3 [PMID:2347024]

Authors

Koizumi M, Shimizu M, Kobashi K

Title

Enzymatic sulfation of quercetin by arylsulfotransferase from a human intestinal bacterium.

Journal

Chem Pharm Bull (Tokyo) 38:794-6 (1990)
DOI:10.1248/cpb.38.794

Reference

4 [PMID:1806284]

Authors

Koizumi M, Akao T, Kadota S, Kikuchi T, Okuda T, Kobashi K

Title

Enzymatic sulfation of polyphenols related to tannins by arylsulfotransferase.

Journal

Chem Pharm Bull (Tokyo) 39:2638-43 (1991)
DOI:10.1248/cpb.39.2638

Reference

5 [PMID:7820100]

Authors

Konishi-Imamura L, Sato M, Dohi K, Kadota S, Namba T, Kobashi K

Title

Enzymatic sulfation of glycosides and their corresponding aglycones by arylsulfate sulfotransferase from a human intestinal bacterium.

Journal

Biol Pharm Bull 17:1018-22 (1994)
DOI:10.1248/bpb.17.1018

Reference

6 [PMID:8576095]

Authors

Lee NS, Kim BT, Kim DH, Kobashi K

Title

Purification and reaction mechanism of arylsulfate sulfotransferase from Haemophilus K-12, a mouse intestinal bacterium.

Journal

J Biochem 118:796-801 (1995)
DOI:10.1093/oxfordjournals.jbchem.a124982

Reference

7 [PMID:17202651]

Authors

Kim B, Hyun YJ, Lee KS, Kobashi K, Kim DH

Title

Cloning, expression and purification of arylsulfate sulfotransferase from Eubacterium A-44.

Journal

Biol Pharm Bull 30:11-4 (2007)
DOI:10.1248/bpb.30.11

Other DBs

ExplorEnz - The Enzyme Database:

2.8.2.22

IUBMB Enzyme Nomenclature:

2.8.2.22

ExPASy - ENZYME nomenclature database:

2.8.2.22

BRENDA, the Enzyme Database:

2.8.2.22

CAS:	158254-86-5

DBGET integrated database retrieval system