KEGG ENZYME: 2.8.2.29

ENZYME: 2.8.2.29

Entry

EC 2.8.2.29                 Enzyme

Name

[heparan sulfate]-glucosamine 3-sulfotransferase 2;
glucosaminyl 3-O-sulfotransferase;
heparan sulfate D-glucosaminyl 3-O-sulfotransferase;
isoform/isozyme 2 (3-OST-2, HS3ST2);
3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine 3-sulfotransferase

Class

Transferases;
Transferring sulfur-containing groups;
Sulfotransferases

Sysname

3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine 3-sulfonotransferase

Reaction(IUBMB)

3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate [RN:R05798]

Reaction(KEGG)

R05798

Substrate

3'-phosphoadenylyl sulfate [CPD:C00053];
[heparan sulfate]-glucosamine [CPD:C22549]

Product

adenosine 3',5'-bisphosphate [CPD:C00054];
[heparan sulfate]-glucosamine 3-sulfate [CPD:C11553]

Comment

This enzyme sulfates the residues marked with an asterisk in sequences containing at least -> IdoA2S-> GlcN*-> or -> GlcA2S-> GlcN*-> (symbols as in {iupac/2carb/38::2-Carb-38}). Preference for GlcN2S vs. unmodified GlcN has not yet been established. Additional structural features are presumably required for substrate recognition, since the 3-O-sulfated residue is of low abundance, whereas the above IdoA-containing sequence is quite abundant. This enzyme differs from the other [heparan sulfate]-glucosamine 3-sulfotransferases by modifying selected glucosamine residues preceded by GlcA2S; EC 2.8.2.23 ([heparan sulfate]-glucosamine 3-sulfotransferase 1) prefers GlcA or IdoA, whereas EC 2.8.2.30 ([heparan sulfate]-glucosamine 3-sulfotransferase 3) prefers IdoA2S.

History

EC 2.8.2.29 created 2001

Pathway

ec00534

Glycosaminoglycan biosynthesis - heparan sulfate / heparin

Orthology

K07808

[heparan sulfate]-glucosamine 3-sulfotransferase 2

Genes

HSA:	9956(HS3ST2)

PTR:	467924(HS3ST2)

PPS:	100969271(HS3ST2)

GGO:	101138321(HS3ST2)

PON:	100459958(HS3ST2)

NLE:	100590606(HS3ST2)

HMH:	116471133(HS3ST2)

MCC:	699722(HS3ST2)

MCF:	102143244(HS3ST2)

MTHB:

126943946

MNI:	105485010(HS3ST2)

CSAB:

103229688(HS3ST2)

CATY:

105586248(HS3ST2)

PANU:

101001300(HS3ST2)

TGE:	112614305(HS3ST2)

MLEU:

105545160(HS3ST2)

RRO:	104658241(HS3ST2)

RBB:	108513770 108538879(HS3ST2)

TFN:	117087502(HS3ST2)

PTEH:

111524206(HS3ST2)

CANG:

105502962(HS3ST2)

CJC:	100405177(HS3ST2)

SBQ:	101034115(HS3ST2)

CIMI:

108308516(HS3ST2)

CSYR:

103254962(HS3ST2)

MMUR:

105879736(HS3ST2)

LCAT:

123632477(HS3ST2)

PCOQ:

105810908(HS3ST2)

OGA:	100966487(HS3ST2)

MMU:	195646(Hs3st2)

MCAL:

110299038(Hs3st2)

MPAH:

110331923(Hs3st2)

RNO:	293451(Hs3st2)

MCOC:

116102901(Hs3st2)

ANU:	117715285(Hs3st2)

MUN:	110550644(Hs3st2)

CGE:	100765580(Hs3st2)

MAUA:

101830825(Hs3st2)

PROB:

127228282(Hs3st2)

PLEU:

114692188(Hs3st2)

MORG:

121458020(Hs3st2)

MFOT:

126502387

NGI:	103742741(Hs3st2)

HGL:	101715838(Hs3st2)

CPOC:

100720379(Hs3st2)

CCAN:

109678012(Hs3st2)

DORD:

105981814(Hs3st2)

DSP:	122116186(Hs3st2)

PLOP:

125340823(Hs3st2)

NCAR:

124969813

MMMA:

107146549(Hs3st2)

OCU:

100349071

OPI:	101520995(HS3ST2)

TUP:	102470961(HS3ST2)

GVR:	103594076(HS3ST2)

CFA:	489975(HS3ST2)

CLUD:

112640248(HS3ST2)

VVP:	112908295(HS3ST2)

VLG:	121486244(HS3ST2)

NPO:	129519157(HS3ST2)

AML:	100475753(HS3ST2)

UMR:	103668867(HS3ST2)

UAH:	113267566(HS3ST2)

UAR:	123778849(HS3ST2)

ELK:	111162195 111162334

LLV:

125090267

MPUF:

101671242(HS3ST2)

MNP:	132026809(HS3ST2)

MLK:	131819605(HS3ST2)

NVS:	122895405(HS3ST2)

ORO:	101384501(HS3ST2)

EJU:	114198795(HS3ST2)

ZCA:	113932147(HS3ST2)

MLX:	117999137(HS3ST2)

NSU:	110577492(HS3ST2)

LWW:

102731229

FCA:	101090732(HS3ST2)

PYU:	121019387(HS3ST2)

PCOO:

112853121(HS3ST2)

PBG:	122471560(HS3ST2)

PVIV:

125154853(HS3ST2)

LRUF:

124517915

PTG:	102955706(HS3ST2)

PPAD:

109255578(HS3ST2)

PUC:

125927959

AJU:

113592425

HHV:	120233281(HS3ST2)

BTA:	532099(HS3ST2)

BOM:	102266030(HS3ST2)

BIU:	109578864(HS3ST2)

BBUB:

102400846(HS3ST2)

BBIS:

104986570(HS3ST2)

CHX:	102183286(HS3ST2)

OAS:	101116370(HS3ST2)

BTAX:

128066073(HS3ST2)

ODA:	120876063(HS3ST2)

MBEZ:

129545450(HS3ST2)

SSC:	100522426(HS3ST2)

CFR:	102517676(HS3ST2)

CBAI:

105073683(HS3ST2)

CDK:	105094820(HS3ST2)

VPC:	102545006(HS3ST2)

BACU:

103004974(HS3ST2)

BMUS:

118881407(HS3ST2)

LVE:	103086879(HS3ST2)

OOR:	101273003(HS3ST2)

DLE:	111182252(HS3ST2)

PCAD:

102992441(HS3ST2)

PSIU:

116740667(HS3ST2)

NASI:

112399427(HS3ST2)

ECB:	100068342(HS3ST2)

EPZ:	103544564(HS3ST2)

EAI:	106846156(HS3ST2)

MYB:	102257576(HS3ST2)

MYD:	102760096(HS3ST2)

MMYO:

118656376(HS3ST2)

MLF:

102440987

PKL:	118731604(HS3ST2)

MNA:	107544805(HS3ST2)

DRO:	112304712(HS3ST2)

SHON:

118974842(HS3ST2)

AJM:	119045686(HS3ST2)

PDIC:

114503713(HS3ST2)

PHAS:

123825591(HS3ST2)

MMF:	118642641(HS3ST2)

PPAM:

129076801(HS3ST2)

HAI:	109386564(HS3ST2)

RFQ:	117019840(HS3ST2)

PALE:

102883217(HS3ST2)

PGIG:

120584549(HS3ST2)

PVP:	105301661(HS3ST2)

RAY:	107516096(HS3ST2)

MJV:	108395381(HS3ST2)

TOD:	119241833(HS3ST2)

SARA:

101546097(HS3ST2)

LAV:	100670647(HS3ST2)

TMU:

101354165

ETF:	101655983(HS3ST2)

DNM:	101413942(HS3ST2)

MDO:	100019945(HS3ST2)

GAS:	123232435(HS3ST2)

SHR:	100914793(HS3ST2)

AFZ:

127540224

PCW:	110201424(HS3ST2)

OAA:	100083841(HS3ST2)

GGA:	416581(HS3ST2)

PCOC:

116237443(HS3ST2)

MGP:

100540809

CJO:	107320809(HS3ST2)

TPAI:

128079393(HS3ST2)

LMUT:

125700703(HS3ST2)

NMEL:

110406058(HS3ST2)

APLA:

101800694(HS3ST2)

ACYG:

106046022

CATA:

118256417(HS3ST2)

AFUL:

116495402(HS3ST2)

TGU:	100222527(HS3ST2)

LSR:	110477749(HS3ST2)

SCAN:

103817555

PMOA:

120513234(HS3ST2)

OTC:	121334515(HS3ST2)

PRUF:

121365834(HS3ST2)

GFR:	102044079(HS3ST2)

FAB:	101808999(HS3ST2)

OMA:	130259202(HS3ST2)

PHI:	102113866(HS3ST2)

PMAJ:

107210993(HS3ST2)

CCAE:

111936210(HS3ST2)

CCW:	104684726(HS3ST2)

CBRC:

103615503

ETL:	114061459(HS3ST2)

ZAB:

102063564

ACHL:

103801571(HS3ST2)

SVG:	106859262(HS3ST2)

MMEA:

130576506

HRT:	120759662(HS3ST2)

FPG:	101913235(HS3ST2)

FCH:	102054410(HS3ST2)

CLV:	102088439(HS3ST2)

EGZ:	104134551(HS3ST2)

NNI:	104015158(HS3ST2)

PLET:

104628415(HS3ST2)

EHS:	104511438(HS3ST2)

PCAO:

104044539(HS3ST2)

TALA:

122153979(HS3ST2)

PADL:

103913918(HS3ST2)

AFOR:

103905066

ACHC:

115335823(HS3ST2)

HLE:	104833750(HS3ST2)

AGEN:

126034066

GCL:

127022500

CCRI:

104161907(HS3ST2)

MUI:	104537356(HS3ST2)

BREG:

104633924(HS3ST2)

FGA:	104074609(HS3ST2)

GSTE:

104251657(HS3ST2)

LDI:

104344223

MNB:	103782325(HS3ST2)

OHA:

104329742

SHAB:

115606224(HS3ST2)

DPUB:

104306931(HS3ST2)

PGUU:

104471580(HS3ST2)

ACAR:

104528348

CPEA:

104393101(HS3ST2)

AVIT:

104278012(HS3ST2)

CVF:	104295082(HS3ST2)

RTD:	128913981(HS3ST2)

CUCA:

104065055

TEO:	104377242(HS3ST2)

BRHI:

104488344(HS3ST2)

AAM:	106487617(HS3ST2)

AROW:

112975028(HS3ST2)

NPD:

112959775

TGT:	104569292(HS3ST2)

DNE:	112985383(HS3ST2)

ASN:

102371657

AMJ:	102563033(HS3ST2)

CPOO:

109314786

GGN:	109294437(HS3ST2)

PSS:

102445195

CMY:	102932960(HS3ST2)

CCAY:

125644007(HS3ST2)

DCC:	119862616(HS3ST2)

CPIC:

101942810(HS3ST2)

TST:	117884522(HS3ST2)

CABI:

116816760(HS3ST2)

MRV:	120374124(HS3ST2)

ACS:

100560689

ASAO:

132781543

PVT:

110085030

SUND:

121914653

PBI:

103064628

PMUR:

107302604

CTIG:

120310813

TSR:

106543574

PGUT:

117667335

APRI:

131185012(HS3ST2)

PTEX:

113454085

NSS:	113425838(HS3ST2)

VKO:

123034828

PMUA:

114584827

PRAF:

128401950

ZVI:

118092847

HCG:

128336328

GJA:	107126204(HS3ST2)

STOW:

125431401(HS3ST2)

EMC:

129338950

XLA:	108701605(hs3st2.L) 108703165(hs3st2.S)

XTR:	100492586(hs3st2)

NPR:

108783720

RTEM:

120944390

BBUF:

121007419

BGAR:

122945462 122945496

MUO:	115476286(HS3ST2)

GSH:

117345550

DRE:	571246(hs3st2)

SRX:	107719184 107741797

SANH:

107674621 107703334

SGH:	107550309 107574133

CCAR:

109053513 109087956

CAUA:

113049787 113071519 113077348

CGIB:

127952350 127953253

PTET:

122333270(hs3st2)

LROH:

127155674(hs3st2)

OMC:	131537315(hs3st2)

PPRM:

120488998 120489001

RKG:	130076603(hs3st2)

MAMB:

125270149(hs3st2)

CIDE:

127510127

MASI:

127450081 127451454

TROS:

130560974(hs3st2)

TDW:	130426501(hs3st2)

MANU:

129431858(hs3st2)

IPU:	108256804(hs3st2)

IFU:	128600687(hs3st2)

PHYP:

113536146

SMEO:

124375707(hs3st2)

TFD:	113661747(hs3st2)

TVC:	132864161(hs3st2)

AMEX:

103021790

CMAO:

118805075(hs3st2)

EEE:

113575522

TRU:	101064090 101074017

TFS:	130514992(hs3st2) 130528659

TNG:	GSTEN00013185G001 GSTEN00024006G001 GSTEN00034422G001

LCO:

104918711

NCC:	104964195(hs3st2) 104965376

TBEN:

117473890 117493211(hs3st2)

CGOB:

115012318 115024689

PGEO:

117442983(hs3st2) 117464728

GACU:

117544950 117548287(hs3st2)

EMAC:

134870348 134878363(hs3st2)

ELY:	117247663 117268205(hs3st2)

EFO:	125879000(hs3st2) 125880681

PLEP:

121957100(hs3st2) 121959344

SLUC:

116059702(hs3st2) 116061576

ECRA:

117937242 117958648(hs3st2)

ESP:	116671694 116703403

PFLV:

114569957

GAT:	120819582 120827468(hs3st2)

PPUG:

119212656 119221150(hs3st2)

AFB:	129091563 129097911(hs3st2)

CLUM:

117735141(hs3st2) 117748882

PSWI:

130189284(hs3st2) 130203632

MSAM:

119908305 119916332 119916731(hs3st2)

SCHU:

122868046 122869340(hs3st2)

CUD:	121503659(hs3st2) 121528735

ALAT:

119009873 119013300(hs3st2)

MZE:	101482104 101484787

ONL:	100699275 100702060

OAU:	116318408(hs3st2) 116319843

OLA:	101156579 101160852

OML:	112145926(hs3st2) 112153866

CSAI:

133419072 133421798(hs3st2)

XMA:	102226871 102235101

XCO:	114151872 114160480

XHE:	116727673 116736281

PRET:

103468690 103481129

PFOR:

103143789 103151423

PLAI:

106954124 106959415(hs3st2)

PMEI:

106918741(hs3st2) 106919153

GAF:	122821503(hs3st2) 122823623

PPRL:

129352574(hs3st2) 129377757

CVG:	107083071 107084998

CTUL:

119785269(hs3st2) 119793709

GMU:	124863412 124863934 124874879

NFU:	107378401 107388017

KMR:	108237133 108243701(hs3st2)

ALIM:

106517333 106528639(hs3st2)

NWH:	119423459 119429702

AOCE:

111567923 111584633

MCEP:

124997342(hs3st2) 125022951

CSEM:

103392778(hs3st2) 103399474

POV:	109626603 109626785 109634147(hs3st2)

SSEN:

122759716 122785431(hs3st2)

HHIP:

117753348 117766707(hs3st2)

HSP:	118100170 118123537(hs3st2)

SMAU:

118287893 118289385(hs3st2)

LCF:	108886805 108903027

SDU:	111217673 111220268

SLAL:

111658670 111660490

XGL:	120788062(hs3st2) 120794406

HCQ:	109509140 109519290 109523884

SSCV:

125983879 125991402

SBIA:

133496003 133515103(hs3st2)

PEE:	133415002(hs3st2) 133417921

PTAO:

133466548(hs3st2) 133469247

BPEC:

110159637 110163912 110169180

MALB:

109963604 109965876

BSPL:

114845489 114860786(hs3st2)

SJO:	128378798(hs3st2) 128381536

SASA:

106579182 106601146 106607396

STRU:

115160113 115171185 115198709

OTW:	112223736 112225841 112246019

OMY:	110486321 110491642 110538265

OGO:	124000638 124016472 124047615

ONE:	115103624 115106603 115109878

OKI:	109865502 109892252 109897605

OKE:	118364745 118365322 118365531

SALP:

111978513 111980408 111981488

SNH:	120034556 120044546 120045506

CCLU:

121551748 121570432 121582356

ELS:	105013402 105030850

SFM:	108923900(hs3st2)

PKI:	111833428 111846401

AANG:

118217136(hs3st2) 118219763

LOC:	102685067(hs3st2)

PSPA:

121300658 121331210

ARUT:

117418104 117431277(hs3st2)

PSEX:

120542734(hs3st2)

LCM:	102347024(HS3ST2)

RTP:	109936394(hs3st2)

CPLA:

122560395

HOC:

132825600

LERI:

129706793

CIN:

108949851

LPIC:

129264701

SKO:	102800708 102805062

RPHI:

132718443

DPOL:

127870030 127870036

ATEN:

116286417

SPIS:

111331084

AQU:

105313345

SYNK:

KR100_13710

» show all

Reference

1 [PMID:9988767]

Authors

Shworak NW, Liu J, Petros LM, Zhang L, Kobayashi M, Copeland NG, Jenkins NA, Rosenberg RD.

Title

Multiple isoforms of heparan sulfate D-glucosaminyl 3-O-sulfotransferase. Isolation, characterization, and expression of human cdnas and identification of distinct genomic loci.

Journal

J Biol Chem 274:5170-84 (1999)
DOI:10.1074/jbc.274.8.5170

Sequence

[hsa:9956]

Reference

2 [PMID:9988768]

Authors

Liu J, Shworak NW, Sinay P, Schwartz JJ, Zhang L, Fritze LM, Rosenberg RD

Title

Expression of heparan sulfate D-glucosaminyl 3-O-sulfotransferase isoforms reveals novel substrate specificities.

Journal

J Biol Chem 274:5185-92 (1999)
DOI:10.1074/jbc.274.8.5185