KEGG   ENZYME: 2.8.2.31
Entry
EC 2.8.2.31                 Enzyme                                 
Name
petromyzonol sulfotransferase;
PZ-SULT;
3'-phosphoadenylyl-sulfate:5alpha-cholan-3alpha,7alpha,12alpha,24-tetrol sulfotransferase
Class
Transferases;
Transferring sulfur-containing groups;
Sulfotransferases
Sysname
3'-phosphoadenylyl-sulfate:5alpha-cholan-3alpha,7alpha,12alpha,24-tetrol sulfonotransferase
Reaction(IUBMB)
3'-phosphoadenylyl sulfate + 5alpha-cholan-3alpha,7alpha,12alpha,24-tetrol = adenosine 3',5'-bisphosphate + 5alpha-cholan-3alpha,7alpha,12alpha-triol 24-sulfate [RN:R07797]
Reaction(KEGG)
R07797
Substrate
3'-phosphoadenylyl sulfate [CPD:C00053];
5alpha-cholan-3alpha,7alpha,12alpha,24-tetrol [CPD:C16258]
Product
adenosine 3',5'-bisphosphate [CPD:C00054];
5alpha-cholan-3alpha,7alpha,12alpha-triol 24-sulfate [CPD:C16259]
Comment
The enzyme from the lamprey Petromyzon marinus can also use the corresponding 3-ketone as a substrate. It is stereoselective (5alpha-cholane) and regioselective, exhibiting a preference for an hydroxy group at C-24. The enzyme is inactive when allocholic acid, which has a carboxy group at C-24, is used as a substrate.
History
EC 2.8.2.31 created 2004
Reference
1  [PMID:14657197]
  Authors
Venkatachalam KV, Llanos DE, Karami KJ, Malinovskii VA.
  Title
Isolation, partial purification, and characterization of a novel petromyzonol sulfotransferase from Petromyzon marinus (lamprey) larval liver.
  Journal
J Lipid Res 45:486-95 (2004)
DOI:10.1194/jlr.M300346-JLR200
Other DBs
ExplorEnz - The Enzyme Database: 2.8.2.31
IUBMB Enzyme Nomenclature: 2.8.2.31
ExPASy - ENZYME nomenclature database: 2.8.2.31
BRENDA, the Enzyme Database: 2.8.2.31

  All links  
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (3)   
   KEGG REACTION (1)   
   KEGG RCLASS (2)   
DNA sequence (2)   
   GenBank (1)   
   EMBL (1)   
All databases (9)   

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