KEGG ENZYME: 2.8.2.36

ENZYME: 2.8.2.36

Entry

EC 2.8.2.36                 Enzyme

Name

desulfo-A47934 sulfotransferase;
StaL;
3'-phosphoadenylyl-sulfate:desulfo-A47934 sulfotransferase

Class

Transferases;
Transferring sulfur-containing groups;
Sulfotransferases

Sysname

3'-phosphoadenylyl-sulfate:desulfo-A47934 sulfonotransferase

Reaction(IUBMB)

3'-phosphoadenylyl sulfate + desulfo-A47934 = adenosine 3',5'-bisphosphate + A47934 [RN:R10655]

Reaction(KEGG)

R10655

Substrate

3'-phosphoadenylyl sulfate [CPD:C00053];
desulfo-A47934 [CPD:C20759]

Product

adenosine 3',5'-bisphosphate [CPD:C00054];
A47934 [CPD:C12016]

Comment

The enzyme from the bacterium Streptomyces toyocaensis catalyses the final step in the biosynthesis of the glycopeptide antibiotic A47934, a naturally occuring antibiotic of the vancomycin group.

History

EC 2.8.2.36 created 2014

Orthology

K21015

desulfo-A47934 sulfotransferase

Reference

1 [PMID:16492565]

Authors

Lamb SS, Patel T, Koteva KP, Wright GD

Title

Biosynthesis of sulfated glycopeptide antibiotics by using the sulfotransferase StaL.

Journal

Chem Biol 13:171-81 (2006)
DOI:10.1016/j.chembiol.2005.12.003

Sequence

[ag:AAM80529]

Reference

2 [PMID:17329243]

Authors

Shi R, Lamb SS, Bhat S, Sulea T, Wright GD, Matte A, Cygler M

Title

Crystal structure of StaL, a glycopeptide antibiotic sulfotransferase from Streptomyces toyocaensis.

Journal

J Biol Chem 282:13073-86 (2007)
DOI:10.1074/jbc.M611912200

Sequence

[ag:AAM80529]

Other DBs

ExplorEnz - The Enzyme Database:

2.8.2.36

IUBMB Enzyme Nomenclature:

2.8.2.36

ExPASy - ENZYME nomenclature database:

2.8.2.36

BRENDA, the Enzyme Database:

2.8.2.36

DBGET integrated database retrieval system