KEGG   ENZYME: 2.8.2.40
Entry
EC 2.8.2.40                 Enzyme                                 
Name
omega-hydroxy-beta-dihydromenaquinone-9 sulfotransferase;
stf3 (gene name)
Class
Transferases;
Transferring sulfur-containing groups;
Sulfotransferases
Sysname
3'-phosphoadenylyl-sulfate:omega-hydroxy-beta-dihydromenaquinone-9 sulfotransferase
Reaction(IUBMB)
3'-phosphoadenylyl sulfate + omega-hydroxy-beta-dihydromenaquinone-9 = adenosine 3',5'-bisphosphate + omega-sulfo-beta-dihydromenaquinone-9 [RN:R12794]
Reaction(KEGG)
R12794
Substrate
3'-phosphoadenylyl sulfate [CPD:C00053];
omega-hydroxy-beta-dihydromenaquinone-9 [CPD:C21885]
Product
adenosine 3',5'-bisphosphate [CPD:C00054];
omega-sulfo-beta-dihydromenaquinone-9 [CPD:C22399]
Comment
The enzyme catalyses the last step in the production of omega-sulfo-beta-dihydromenaquinone-9 by members of the Mycobacterium tuberculosis complex.
History
EC 2.8.2.40 created 2021
Orthology
K22905  omega-hydroxy-beta-dihydromenaquinone-9 sulfotransferase
Genes
PPHA: BVH74_17800
MICC: AUP74_01771
MCA: MCA2756
METU: GNH96_00035 GNH96_00395
MMEO: OOT43_10285 OOT43_19265
MMAI: sS8_4162
MSZE: MSZNOR_2490(stf)
MEIN: methR_P0932
NOC: Noc_1729
NHL: Nhal_0284
TVI: Thivi_2192
TTP: E6P07_04950
THIP: N838_15095 N838_32060
THIM: KFB96_18580
TBOG: LT988_06510
TLR: Thiosp_02380 Thiosp_04536
TFRI: Thiofri_02790
TWG: Thiowin_01842
SHAI: LMH63_03440
ABO: ABO_1043
ALN: AS19_11090
ALCA: ASALC70_00614
ADI: B5T_01851
AXE: P40_08825
GSN: YC6258_03339
SDF: ACG33_03610
ENM: EBS_0951
DOE: DENOEST_0413
ABRE: pbN1_33280
THU: AC731_008690
PMOB: HG718_04870
PECT: BN1012_Phect108
MCG: GL4_1680
METG: HT051_10670
MAAD: AZF01_09220
RBM: TEF_20330
CEH: CEW89_09445
SMED: JNX03_18500
LSAL: KBK07_02990
RHP: LPB142_16215
PSEB: EOK75_04360
HGN: E6W36_08420
ABS: AZOBR_p150006
ABQ: ABAZ39_20235
ABF: AMK58_14570
AZT: TSH58p_24410
AOZ: HUE56_02780
AARE: D3093_22255
SKT: IGS68_13670 IGS68_17780
SMUC: JL100_008230 JL100_014915
SROE: JL101_008110 JL101_010375
SUN: SUN_1532
DAF: Desaf_0194
DTI: Desti_0521
PCAY: FRD00_23090
CLS: CXIVA_00400
CSS: Cst_c20830
CSD: Clst_1990
MTU: Rv2267c
MTV: RVBD_2267c
MTC: MT2329
MRA: MRA_2287
MTF: TBFG_12294
MTB: TBMG_01715
MTK: TBSG_01725
MTZ: TBXG_001697
MTG: MRGA327_13980
MTI: MRGA423_14105
MTE: CCDC5079_2103
MTUR: CFBS_2400
MTL: CCDC5180_2075
MTO: MTCTRI2_2302
MTD: UDA_2267c
MTN: ERDMAN_2491
MTJ: J112_12170
MTUB: MT7199_2298
MTUC: J113_15805
MTUE: J114_12160
MTX: M943_11735
MTUL: TBHG_02217
MTUT: HKBT1_2391
MTUU: HKBT2_2393
MTQ: HKBS1_2397
MBO: BQ2027_MB2290C
MBB: BCG_2284c
MBT: JTY_2278
MBM: BCGMEX_2272c
MBK: K60_023520
MBX: BCGT_2090
MAF: MAF_22770
MMIC: RN08_2515
MCE: MCAN_05811 MCAN_22911
MCQ: BN44_50213
MCV: BN43_31509
MCX: BN42_20319 BN42_40189
MCZ: BN45_10647 BN45_50599
MORY: MO_002376
MUL: MUL_0658
MMI: MMAR_0905
MMAE: MMARE11_08550
MLI: MULP_00933
MPSE: MPSD_10360
MSHO: MSHO_26650
MKN: MKAN_03515 MKAN_08310
MYE: AB431_15275
MSHG: MSG_00556(stf3)
MFJ: MFLOJ_29390(stf3)
MSTO: MSTO_33340(stf3)
MSIM: MSIM_19190(stf3)
MSAK: MSAS_51810
MLW: MJO58_02970 MJO58_07380
MPAG: C0J29_08280 C0J29_24340
MCOO: MCOO_03730
MBAI: MB901379_00775
MGAU: MGALJ_24660
MLJ: MLAC_22880(stf3)
MSHJ: MSHI_09970(stf3)
MMAM: K3U93_19820
MOT: LTS72_03075
MPAA: MKK62_14530
MMEH: M5I08_17500
MCB: Mycch_1747
MFT: XA26_45540
MRH: MycrhN_4094
MAIC: MAIC_27010
MANY: MANY_22930
MPHU: MPHO_24890
MBOK: MBOE_28160
MPAE: K0O64_00520 K0O64_14740
MRF: MJO55_09065
MCRO: MI149_15600
MAU: Micau_0536
MIL: ML5_0732
MICB: MicB006_0549
MTUA: CSH63_22545
MTEM: GCE86_08255
RXY: Rxyl_1946
RUB: GBA63_11270
SYD: Syncc9605_0918
SYE: Syncc9902_1491
SYG: sync_0812
SYX: SynWH7803_1701
SYNR: KR49_13905
SYND: KR52_12360
SYNW: SynWH8103_01806
HHG: XM38_041650(stf3)
GLP: Glo7428_1510
MAR: MAE_31770
MPK: VL20_1757
MIQ: B5D77_02895
MVZ: myaer102_07180
CYJ: Cyan7822_5853
CAA: Caka_2387
LUO: HHL09_08300
SOA: G3M56_002050
RBA: RB7157
PSL: Psta_4359
PIR: VN12_12430
RUL: UC8_02040 UC8_53490
RML: FF011L_47510
MFF: MFFC18_41010
ROL: CA51_06410
RUV: EC9_07090
AHEL: Q31a_55000
LCRE: Pla8534_63940
AAGG: ETAA8_30890
BVO: Pan97_14450
BREM: PSR63_03585
RLC: K227x_09690
SMAM: Mal15_66790
SNEP: Enr13x_68390
TTF: THTE_1115
LPAV: PLANPX_4132
LLH: I41_43190
AMUC: Pan181_14740
PND: Pla175_15880 Pla175_45830
AMOB: HG15A2_33700
BMEI: Spa11_34930
PLM: Plim_0831
PEH: Spb1_15890
PBS: Plabr_0431 Plabr_1084
PLS: VT03_20370
FMR: Fuma_02395 Fuma_03636 Fuma_05923
GMR: GmarT_50380
GIM: F1728_20290
GPN: Pan110_50120
GFM: Enr17x_50160
MRI: Mal4_44530 Mal4_45320
SDYN: Mal52_07500
TPOL: Mal48_22390
CCOS: Pan44_03570 Pan44_28500
PVAR: SH412_002337 SH412_002745
CCOP: Mal65_46130 Mal65_47980
GES: VT84_18745
GOG: C1280_16330
GMS: SOIL9_15250 SOIL9_28300
TIM: GMBLW1_07820
LRS: PX52LOC_02136
FTJ: FTUN_7086
ULI: ETAA1_26670
TSPH: KIH39_11780
SACI: Sinac_5512
AGV: OJF2_54860
PGIN: FRZ67_20620
LACS: H4075_18220
PROW: OO006_13145
CABY: Cabys_1314 Cabys_1386
 » show all
Reference
1  [PMID:16537518]
  Authors
Mougous JD, Senaratne RH, Petzold CJ, Jain M, Lee DH, Schelle MW, Leavell MD, Cox JS, Leary JA, Riley LW, Bertozzi CR.
  Title
A sulfated metabolite produced by stf3 negatively regulates the virulence of Mycobacterium tuberculosis.
  Journal
Proc Natl Acad Sci U S A 103:4258-63 (2006)
DOI:10.1073/pnas.0510861103
Reference
2  [PMID:18928249]
  Authors
Holsclaw CM, Sogi KM, Gilmore SA, Schelle MW, Leavell MD, Bertozzi CR, Leary JA
  Title
Structural characterization of a novel sulfated menaquinone produced by stf3 from Mycobacterium tuberculosis.
  Journal
ACS Chem Biol 3:619-24 (2008)
DOI:10.1021/cb800145r
Other DBs
ExplorEnz - The Enzyme Database: 2.8.2.40
IUBMB Enzyme Nomenclature: 2.8.2.40
ExPASy - ENZYME nomenclature database: 2.8.2.40
BRENDA, the Enzyme Database: 2.8.2.40

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Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (1043)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (232)   
   KEGG MGENES (810)   
Protein sequence (6)   
   UniProt (3)   
   SWISS-PROT (3)   
Protein domain (2)   
   InterPro (2)   
All databases (1057)   

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