KEGG ENZYME: 2.8.3.26

ENZYME: 2.8.3.26

Entry

EC 2.8.3.26                 Enzyme

Name

succinyl-CoA:mesaconate CoA transferase;
mct (gene name)

Class

Transferases;
Transferring sulfur-containing groups;
CoA-transferases

Sysname

succinyl-CoA:mesaconate CoA transferase

Reaction(IUBMB)

succinyl-CoA + mesaconate = 2-methylfumaryl-CoA + succinate [RN:R10904]

Reaction(KEGG)

R10904

Substrate

succinyl-CoA [CPD:C00091];
mesaconate [CPD:C01732]

Product

2-methylfumaryl-CoA [CPD:C06028];
succinate [CPD:C00042]

Comment

The enzyme participates in the methylaspartate cycle, an anaplerotic pathway that operates in some members of the haloarchaea and forms malate from acetyl-CoA.

History

EC 2.8.3.26 created 2020

Pathway

ec00630

Glyoxylate and dicarboxylate metabolism

ec01100

Metabolic pathways

ec01120

Microbial metabolism in diverse environments

Orthology

K19280

succinyl-CoA:mesaconate CoA transferase

Genes

HALX:

M0R89_18065

HAXY:

NGM07_04595

SALI:

L593_04685

HMA:

rrnAC0683

HHI:	HAH_1336(caiB)

HHN:	HISP_06840

HAB:	SG26_14685

HTA:	BVU17_06510

HALJ:

G9465_08560

HSIN:

KDQ40_06790

HMU:

Hmuk_2979

HALZ:

E5139_02170

HALL:

LC1Hm_2316(mct)

HAZP:

GBQ70_02170

HRR:	HZS55_20010

HPEL:

HZS54_23510

HTU:

Htur_1595

HSAL:

JMJ58_00660

HAKZ:

J0X25_14785

NMG:	Nmag_3333(mct)

HXA:	Halxa_3154

NAT:

NJ7G_3294

NPE:	Natpe_2595

NVR:	FEJ81_11905

NPL:	FGF80_10945

NAY:	HYG81_14715

HALY:

HYG82_17335

HJT:	DVR14_02960

HLO:	J0X27_02320

NGE:	Natgr_3389

HRU:	Halru_1553

SAWL:

NGM29_08795

HALV:

NGM15_00960

NOU:	Natoc_1514

HLR:	HALLA_10860

HLC:	CHINAEXTREME16100

NAJ:	B1756_12000

NAG:	AArcMg_1650

NAN:	AArc1_1989

NARA:

QQ977_05675(mct)

NBG:	DV706_13005

NAS:	GCU68_13750

HDA:	BB347_04035

» show all

Reference

1 [PMID:21252347]

Authors

Khomyakova M, Bukmez O, Thomas LK, Erb TJ, Berg IA

Title

A methylaspartate cycle in haloarchaea.

Journal

Science 331:334-7 (2011)
DOI:10.1126/science.1196544

Sequence

[hma:rrnAC0683]

Reference

2 [PMID:28932214]

Authors

Borjian F, Johnsen U, Schonheit P, Berg IA

Title

Succinyl-CoA:Mesaconate CoA-Transferase and Mesaconyl-CoA Hydratase, Enzymes of the Methylaspartate Cycle in Haloarcula hispanica.

Journal

Front Microbiol 8:1683 (2017)
DOI:10.3389/fmicb.2017.01683

Sequence

[hhi:HAH_1336]

Other DBs

ExplorEnz - The Enzyme Database:

2.8.3.26

IUBMB Enzyme Nomenclature:

2.8.3.26

ExPASy - ENZYME nomenclature database:

2.8.3.26

BRENDA, the Enzyme Database:

2.8.3.26

DBGET integrated database retrieval system