Entry
Name
propanoyl-CoA:succinate CoA transferase;
succinyl-CoA:propionate CoA-transferase;
propionyl-CoA:succinyl-CoA transferase;
ASCT;
scpC (gene name)
Class
Transferases;
Transferring sulfur-containing groups;
CoA-transferases
BRITE hierarchy
Sysname
propanoyl-CoA:succinate CoA transferase
Reaction(IUBMB)
propanoyl-CoA + succinate = propanoate + succinyl-CoA [RN:
R11773 ]
Reaction(KEGG)
Substrate
Product
Comment
The enzyme is most specific in Escherichia coli, where the preferred substrates are propanoyl-CoA and succinate. In other organisms, the enzyme uses acetyl-CoA at the same rate as propanoyl-CoA (cf. EC
2.8.3.18 , succinyl-CoA:acetate CoA-transferase).
History
EC 2.8.3.27 created 2022
Pathway
Orthology
K22214 propionyl-CoA:succinyl-CoA transferase
Genes
ECOO : ECRM13514_3780(ygfH)
ECOH : ECRM13516_3641(ygfH)
EDJ : ECDH1ME8569_2821(scpC)
SFT : NCTC1_03196(ygfH_1) NCTC1_03197(ygfH_2)
YEE : YE5303_20611 YE5303_34011
POC : NCTC13071_00558(scpC)
» show all
Taxonomy
Reference
Authors
ALLEN SH, KELLERMEYER RW, STJERNHOLM RL, WOOD HG.
Title
PURIFICATION AND PROPERTIES OF ENZYMES INVOLVED IN THE PROPIONIC ACID FERMENTATION.
Journal
Reference
2
Authors
Schulz, T.KF. and Kluytmans, J.H.
Title
Pathway of propionate synthesis in the sea mussel Mytilus edulis L.
Journal
Comp Biochem Physiol B Comp Biochem 75:365-372 (1983)
Reference
Authors
Haller T, Buckel T, Retey J, Gerlt JA
Title
Discovering new enzymes and metabolic pathways: conversion of succinate to propionate by Escherichia coli.
Journal
Reference
Authors
van Grinsven KW, van Hellemond JJ, Tielens AG.
Title
Acetate:succinate CoA-transferase in the anaerobic mitochondria of Fasciola hepatica.
Journal
Sequence
Reference
Authors
Zhang B, Lingga C, Bowman C, Hackmann TJ.
Title
A New Pathway for Forming Acetate and Synthesizing ATP during Fermentation in Bacteria.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.8.3.27
ExPASy - ENZYME nomenclature database: 2.8.3.27