KEGG   ENZYME: 2.8.3.28
Entry
EC 2.8.3.28                 Enzyme                                 
Name
phenylsuccinyl-CoA transferase;
iaaL (gene name)
Class
Transferases;
Transferring sulfur-containing groups;
CoA-transferases
Sysname
succinyl-CoA:2/3-phenylsuccinate CoA-transferase
Reaction(IUBMB)
(1) phenylsuccinate + succinyl-CoA = 2-phenylsuccinyl-CoA + succinate [RN:R12981];
(2) phenylsuccinate + succinyl-CoA = 3-phenylsuccinyl-CoA + succinate [RN:R12982]
Reaction(KEGG)
R12981 R12982
Substrate
phenylsuccinate [CPD:C22494];
succinyl-CoA [CPD:C00091]
Product
2-phenylsuccinyl-CoA [CPD:C22495];
succinate [CPD:C00042];
3-phenylsuccinyl-CoA [CPD:C22496]
Comment
The enzyme, characterized from the bacterium Aromatoleum aromaticum, is involved in degradation of (indol-3-yl)acetate, where it is believed to function on (2-aminophenyl)succinate. It has a broad substrate specificity towards other C4-dicarboxylic acids, phenylacetate, and the non-physiological compound 2-naphthylacetate. The enzyme produces 2- and 3-phenylsuccinyl-CoA in equimolar amounts. It can also perform an intramolecular transfer of the CoA moiety to convert 2-phenylsuccinyl-CoA to 3-phenylsuccinyl-CoA.
History
EC 2.8.3.28 created 2022
Orthology
K25761  phenylsuccinyl-CoA transferase
Genes
EBAebA2066
ABREpbN1_13160
APETToN1_50440
AZIAzCIB_1791
TCLTchl_1901
TAKTharo_2551
DDZDSYM_16480
RPERPE_3212
MAGXXM1_2477
Reference
1  [PMID:27102732]
  Authors
Schuhle K, Nies J, Heider J.
  Title
An indoleacetate-CoA ligase and a phenylsuccinyl-CoA transferase involved in anaerobic metabolism of auxin.
  Journal
Environ Microbiol 18:3120-32 (2016)
DOI:10.1111/1462-2920.13347
  Sequence
[eba:ebA2066]
Other DBs
ExplorEnz - The Enzyme Database: 2.8.3.28
IUBMB Enzyme Nomenclature: 2.8.3.28
ExPASy - ENZYME nomenclature database: 2.8.3.28
BRENDA, the Enzyme Database: 2.8.3.28

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