KEGG ENZYME: 2.8.5.1

ENZYME: 2.8.5.1

Entry

EC 2.8.5.1                  Enzyme

Name

S-sulfo-L-cysteine synthase (3-phospho-L-serine-dependent);
cysK2 (gene name)

Class

Transferases;
Transferring sulfur-containing groups;
Thiosulfotransferases

Sysname

thiosulfate:3-phospho-L-serine thiosulfotransferase

Reaction(IUBMB)

O-phospho-L-serine + thiosulfate = S-sulfo-L-cysteine + phosphate [RN:R12092]

Reaction(KEGG)

R12092

Substrate

O-phospho-L-serine [CPD:C01005];
thiosulfate [CPD:C00320]

Product

S-sulfo-L-cysteine [CPD:C05824];
phosphate [CPD:C00009]

Comment

The enzyme, which has been characterized from the bacterium Mycobacterium tuberculosis, has no activity with O-acetyl-L-serine. Requires pyridoxal 5'-phosphate. cf. EC 2.5.1.144, S-sulfo-L-cysteine synthase (O-acetyl-L-serine-dependent).

History

EC 2.8.5.1 created 2018

Pathway

ec00270

Cysteine and methionine metabolism

ec01100

Metabolic pathways

Orthology

K22847

S-sulfo-L-cysteine synthase (3-phospho-L-serine-dependent)

Genes

SMAF:

D781_0294

SERA:

Ser39006_009330

SERQ:

CWC46_09325

DIC:	Dpoa569_001723

VGA:	BSQ33_06610

THIS:

HZT40_06145

BMAE:

DM78_1587

BPM:	BURPS1710b_2157

BPL:	BURPS1106A_2021

BPD:	BURPS668_2001

BPR:	GBP346_A2047

BPSE:

BDL_236

BPSM:

BBQ_1576

BPSU:

BBN_1701

BPSD:

BBX_2173

BPZ:	BP1026B_I1669

BPQ:	BPC006_I2069

BPK:

BBK_3200

BPSH:

DR55_2808

BPSA:

BBU_411

BPSO:

X996_2431

BUT:

X994_878

BOK:

DM82_5241

BOC:

BG90_5368

BUU:	WS70_22945

BVE:

AK36_3728

BGD:	bgla_1g16450

BGO:

BM43_2871

BUK:

MYA_4746

AAA:

Acav_2531

SNIV:

SFSGTM_32230

MLN:	A9174_34630

MOP:	Mesop_2827

MESM:

EJ066_12365

MJR:	EB229_34580

AAK:	AA2016_5082 AA2016_6364

ESJ:	SJ05684_a37250

RIR:	BN877_p0206

RGA:	RGR602_PB00321

ABAW:

D5400_09955

OAN:

Oant_0655

OAH:

DR92_2288

BVV:	BHK69_31135

BOI:	BLM15_29675

CHEL:

AL346_15250

TAW:	EI545_21195

AZM:	DM194_14960

AOZ:	HUE56_06355

SUR:	STAUR_4852

MBD:	MEBOL_007806 MEBOL_007807

CFUS:

CYFUS_006579

SBF:	JCM31447_02650

BTF:	YBT020_25570 YBT020_25575

BTM:

MC28_E121

BTN:	BTF1_31996

BWD:	CT694_33820

BTRO:

FJR70_30745

BLE:	BleG1_0497

BKO:	CKF48_11865

VIG:	BKP57_04910

RMF:	D5E69_05065

BBE:	BBR47_51900 BBR47_51910

BHUI:

LOK74_02695

BBOR:

RFB14_05730 RFB14_22355

BRUM:

NDK47_04600

TUM:	CBW65_03370 CBW65_03375

TAB:	CIG75_03435 CIG75_03440

KPUL:

GXN76_08325 GXN76_08330 GXN76_09110

KEB:	GXN75_06655 GXN75_06660

STD:	SPPN_10420

LBT:	AYR52_04430

MTU:	Rv0848(cysK2)

MTV:

RVBD_0848

MRA:	MRA_0856(cysK2)

MTF:	TBFG_10865

MTB:	TBMG_03142

MTK:	TBSG_03162

MTZ:	TBXG_003121

MTG:	MRGA327_05335

MTI:	MRGA423_05325

MTE:	CCDC5079_0783

MTUR:

CFBS_0891(cysK2)

MTL:	CCDC5180_0776

MTO:	MTCTRI2_0871(cysK2)

MTD:	UDA_0848(cysK2)

MTN:	ERDMAN_0940(cysK2)

MTJ:	J112_04555

MTUB:

MT7199_0867

MTUE:

J114_04515

MTX:	M943_04445

MTUL:

TBHG_00836

MTUT:

HKBT1_0891(cysK2)

MTUU:

HKBT2_0892(cysK2)

MTQ:	HKBS1_0891(cysK2)

MBO:	BQ2027_MB0871(cysK2)

MBB:	BCG_0900(cysK2)

MBT:	JTY_0870(cysK2)

MBM:	BCGMEX_0871(cysK2)

MBK:	K60_009060

MBX:

BCGT_0654

MAF:	MAF_08570(cysK2)

MMIC:

RN08_0944

MCE:	MCAN_08501(cysK2)

MCQ:	BN44_10929(cysK)

MCV:	BN43_20299(cysK)

MCX:	BN42_20624(cysK)

MCZ:	BN45_20137(cysK)

MORY:

MO_000908(cysK2)

MID:	MIP_04157 MIP_04205 MIP_04245 MIP_06534 MIP_06538

MYO:	OEM_27880 OEM_28170 OEM_32590 OEM_32620

MCHI:

AN480_12830 AN480_12925 AN480_17285 AN480_29515 AN480_29600

MMI:	MMAR_4768(cysK2)

MMAE:

MMARE11_45970(cysK2)

MLI:	MULP_04996(cysK2)

MPSE:

MPSD_49410(cysK2)

MSHO:

MSHO_57790(cysK2)

MMC:	Mmcs_1444 Mmcs_4197

MKM:	Mkms_1462 Mkms_4263

MJL:	Mjls_4424 Mjls_4560

MMM:	W7S_14240 W7S_14385 W7S_21760 W7S_21775

MKN:	MKAN_10175

MYV:	G155_21715

MHAD:

B586_05670

MDX:	BTO20_20670 BTO20_20760

MKU:	I2456_00990 I2456_17810

MXE:	MYXE_22280

MPAG:

C0J29_31405 C0J29_31440

MBAI:

MB901379_04178(sbnA_1)

MGAU:

MGALJ_18520(cysK2)

MLJ:	MLAC_02480(cysK2)

MSPG:

F6B93_06430 F6B93_19150

MOT:	LTS72_16170 LTS72_26020 LTS72_26040

MADI:

A7U43_03280

MVA:

Mvan_5856

MGI:

Mflv_0899

MSP:	Mspyr1_52450 Mspyr1_54570

MCB:	Mycch_5733

MFT:	XA26_44300

MRH:	MycrhN_2793

MDU:	MDUV_43860(cysK2)

MCHT:

MCHIJ_52420(cysK2)

MFX:	MFAL_33300(cysK2)

MIJ:	MINS_20690(cysK2)

MALV:

MALV_20470(cysK2_1) MALV_50380(cysK2_2)

MGAD:

MGAD_03450(cysK2_1) MGAD_06270(cysK2_2)

MAUB:

MAUB_63090(cysK2)

MPOF:

MPOR_48650(cysK2)

MPHU:

MPHO_09990(cysK2)

MMUC:

C1S78_013240

MMAT:

MMAGJ_03010(cysK2)

MBOK:

MBOE_29480(cysK2)

MFG:	K6L26_10040 K6L26_16565

MSEI:

MSEDJ_56520(cysK2)

MFLV:

NCTC10271_02348(cysK_2)

MCEE:

MCEL_42540(cysK2)

MBRM:

L2Z93_001217

MMON:

EWR22_22650

MSEN:

K3U95_08190

MPAE:

K0O64_20125

MGRO:

FZ046_14055

MAB:

MAB_1273

MMV:	MYCMA_0230 MYCMA_0678

MABB:

MASS_1270

MABL:

MMASJCM_1298

MCHE:

BB28_06270

MIZ:	BAB75_02755 BAB75_06875

MSTE:

MSTE_01244

MSAO:

MYCSP_05585

MSAL:

DSM43276_01140(sbnA_2)

NFA:	PNF1_240 PNF1_800

NCY:	NOCYR_1301 NOCYR_4030

NBR:	O3I_021850

NSL:	BOX37_11300

NSR:	NS506_03058

NTP:	CRH09_21180

NOZ:	DMB37_03710

NOD:	FOH10_16975

NAH:	F5544_18010

NAD:	NCTC11293_02051(cysK_2) NCTC11293_02191(cysK_3) NCTC11293_04496(cysK_4) NCTC11293_04790(cysK_5)

NWL:	NWFMUON74_57370

NIE:	KV110_14465 KV110_15955

NHU:	H0264_22000 H0264_27310

NYA:	LTV02_07100

NGP:	LTT66_12425 LTT66_12465 LTT66_12585 LTT66_12675 LTT66_12700 LTT66_30510 LTT66_32490

NSPU:

IFM12276_49830(cysK2)

ROP:	ROP_04290 ROP_pROB01-02110

RBY:	CEJ39_01350

RAV:	AAT18_22155

RRZ:	CS378_11920 CS378_13030

ROZ:	CBI38_04050 CBI38_35580

RPSK:

JWS13_03465 JWS13_26880

GBR:

Gbro_2603

GTA:	BCM27_13560

GRU:	GCWB2_23375(sbnA)

GHN:	MVF96_12890

GAMI:

IHQ52_14205 IHQ52_19325

TPR:

Tpau_3720

SGB:	WQO_01640 WQO_04430

SFI:

SFUL_851

SANL:

KZO11_01405

SGRF:

SGFS_004950 SGFS_063680

SCB:	SCAB_81941 SCAB_89801(cysK2)

SVL:	Strvi_2260 Strvi_4637

SHY:	SHJG_0605 SHJG_8381

SHO:	SHJGH_0438 SHJGH_8142

SRC:	M271_00285

SMAL:

SMALA_0850 SMALA_4055 SMALA_6628 SMALA_7561 SMALA_7563 SMALA_7774

SSOI:

I1A49_07750 I1A49_36915 I1A49_42710

SFA:

Sfla_0474

SBH:	SBI_00132 SBI_00304

SDV:	BN159_2321(cysK2)

SALS:

SLNWT_1273 SLNWT_3845

STRP:

F750_6520

SCI:	B446_01550 B446_33740

SVT:	SVTN_20190

STRE:

GZL_08241 GZL_08796

SLD:	T261_1932 T261_4035 T261_7505

SLC:	SL103_18575

SXI:	SXIM_05300 SXIM_52660

STRM:

M444_23765 M444_32695

STRC:

AA958_14630

SCZ:	ABE83_10045

SCX:	AS200_14540 AS200_15240 AS200_16900 AS200_44535

SRW:	TUE45_01194(sbnA_1)

STRF:

ASR50_33795

SLE:	sle_13800(sle_13800)

SCLF:

BB341_05285 BB341_14930

SGS:	AVL59_16865 AVL59_23090 AVL59_26925

SGM:	GCM10017557_07060(cysK2)

SPHW:

NFX46_26080

SLS:	SLINC_7467

SNR:	SNOUR_37030 SNOUR_39960

SALU:

DC74_1087 DC74_7059

SALL:

SAZ_05930 SAZ_36615

SPLU:

LK06_030140

STRD:

NI25_07115 NI25_07360

SNW:	BBN63_00355 BBN63_06130 BBN63_15905

SAUO:

BV401_08065

SVU:	B1H20_34215

SGV:	B1H19_31615

SLAU:

SLA_3947

SALF:

SMD44_04024(cysK)

SALJ:

SMD11_0828(cysK) SMD11_3205(cysK) SMD11_3206(cysK)

SLX:	SLAV_04965(sbnA1)

SFK:

KY5_3864c

SNZ:	DC008_00750

SRJ:	SRO_0812 SRO_1336 SRO_1552 SRO_1553

SLK:	SLUN_04225 SLUN_22160 SLUN_34600

SQZ:	FQU76_32795

SCYA:

EJ357_01025 EJ357_01035 EJ357_03935 EJ357_35980

SKA:	CP970_06505 CP970_22905

SGZ:	C0216_19470 C0216_31660 C0216_32070

SNK:	CP967_00905 CP967_12430

SRK:	FGW37_29235

SGAL:

CP966_04205

SSPO:

DDQ41_25875

SVR:	CP971_29440

SPAD:

DVK44_32435

SAQU:

EJC51_04875 EJC51_43285

SGF:	HEP81_00791 HEP81_01303 HEP81_01738 HEP81_01739

SCAV:

CVT27_24660

SSEO:

D0Z67_27225 D0Z67_27230

SBY:	H7H31_32515

SRIM:

CP984_09290

SSUB:

CP968_04435 CP968_16780 CP968_31390

SPHV:

F9278_03965

SFUG:

CNQ36_29700

SPAC:

B1H29_04705

STSU:

B7R87_01045

SCHA:

CP983_03760 CP983_10120

SGX:	H4W23_12745 H4W23_21435

SCOE:

CP976_38290

SBAT:

G4Z16_01825

SSPB:

CP982_39520

SNF:	JYK04_01698(cysK2_1) JYK04_07072(cysK2_3)

SBRO:

GQF42_08375

SATA:

C5746_34085

SFEU:

IM697_20050

SDW:	K7C20_01110

SAUH:

SU9_000815

SPRA:

CP972_26945

SPEU:

CGZ69_35680 CGZ69_35790

SROI:

IAG44_03450 IAG44_37590

SXN:	IAG42_02365 IAG42_34700

SANU:

K7396_35040

SINE:

KI385_01465 KI385_34740

SLF:	JEQ17_05930 JEQ17_48745

SDEC:

L3078_02335 L3078_05485

SAOV:

G3H79_19475

SDUR:

M4V62_42570

SYAN:

NRK68_29180

SAKB:

K1J60_40540 K1J60_43050

STAA:

LDH80_19120

SNIG:

HEK616_32350 HEK616_49510

SCAE:

IHE65_40785

STUB:

MMF93_00115

SCIR:

STRCI_000178 STRCI_006265

SXT:	KPP03845_100605(cysK2)

STUD:

STRTU_001428 STRTU_007026

SENG:

OJ254_29500

SGK:	PET44_31135

SANT:

QR300_40610

SYUN:

MOV08_38245 MOV08_40815

SARG:

HKX69_01505

SJN:	RI060_10015

SHAU:

K9S39_03475 K9S39_11950 K9S39_26205

SKG:	KJK29_08050

SCOA:

QU709_03250

SLAI:

P8A22_06230

SROC:

RGF97_03465

SFP:	QUY26_20945

STRZ:

OYE22_32505

KSK:

KSE_05300

KAB:	B7C62_18890

KIS:	HUT16_01770

AGLA:

OIE69_35205 OIE69_40070

PACD:

EGX94_11085

KFL:

Kfla_5741

NGV:	CDO52_26280

SRO:

Sros_4971

NOW:	GBF35_28730

NCX:	Nocox_20005(sbnA1) Nocox_22035(sbnA2)

SEN:	SACE_1726 SACE_6328

SACG:

FDZ84_32280 FDZ84_35350(aroF)

AOI:	AORI_3636(cysK) AORI_5322(cysK)

AJA:	AJAP_20955 AJAP_38285

AMYB:

BKN51_10615

AMYY:

YIM_22540(sbnA1) YIM_35370(sbnA5)

AORI:

SD37_07395

AROO:

NQK81_04365 NQK81_21270 NQK81_21665 NQK81_28385 NQK81_35085

PSEQ:

AD006_31200

PECQ:

AD017_30035

PHH:	AFB00_19415

PAUT:

Pdca_05570 Pdca_71290

PBRO:

HOP40_19980 HOP40_20520

PPEL:

H6H00_28340 H6H00_28940

APRE:

CNX65_22405 CNX65_23745

AMI:	Amir_4500 Amir_4781

SESP:

BN6_51430

SSYI:

EKG83_17025 EKG83_20585

KAL:

KALB_4827

KUT:	JJ691_65140

KBU:	Q4V64_35645

KPHY:

AOZ06_34875

LED:	BBK82_35780

AHG:	AHOG_13695(cysK)

ACTA:

C1701_17215

ALO:

CRK55305

ACTU:

Actkin_04206(sbnA_1)

CROS:

N8J89_05750

STP:	Strop_2310

SAQ:

Sare_4585

MICH:

FJK98_22250

MCAB:

HXZ27_18850

MSAG:

GCM10017556_36640 GCM10017556_36660 GCM10017556_51490

VMA:	VAB18032_22180

VER:	HUT12_14625

ASE:	ACPL_336(cbs)

AFS:

AFR_18475

ACTS:

ACWT_0221

PRY:	Prubr_63250

NHY:	JQS43_24645

CCAZ:

COUCH_15010

SNA:	Snas_2436 Snas_4716

AEY:	CDG81_05040

KBS:	EPA93_15145 EPA93_15150 EPA93_15485

KAN:	IMCC3317_07860(sbnA)

» show all

Reference

1 [PMID:25022854]

Authors

Steiner EM, Both D, Lossl P, Vilaplana F, Schnell R, Schneider G

Title

CysK2 from Mycobacterium tuberculosis is an O-phospho-L-serine-dependent S-sulfocysteine synthase.

Journal

J Bacteriol 196:3410-20 (2014)
DOI:10.1128/JB.01851-14

Sequence

[mtu:Rv0848]

Other DBs

ExplorEnz - The Enzyme Database:

2.8.5.1

IUBMB Enzyme Nomenclature:

2.8.5.1

ExPASy - ENZYME nomenclature database:

2.8.5.1

BRENDA, the Enzyme Database:

2.8.5.1

All links

Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (547)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (516)   
   KEGG MGENES (30)   
Protein sequence (2)   
   UniProt (1)   
   SWISS-PROT (1)   
Protein domain (3)   
   InterPro (3)   
All databases (562)   

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