KEGG ENZYME: 3.1.1.104

ENZYME: 3.1.1.104

Entry

EC 3.1.1.104                Enzyme

Name

5-phospho-D-xylono-1,4-lactonase

Class

Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases

Sysname

5-phospho-D-xylono-1,4-lactone hydrolase

Reaction(IUBMB)

(1) D-xylono-1,4-lactone 5-phosphate + H2O = 5-phospho-D-xylonate [RN:R12248];
(2) L-arabino-1,4-lactone 5-phosphate + H2O = 5-phospho-L-arabinate [RN:R12249]

Reaction(KEGG)

R12248 R12249

Substrate

D-xylono-1,4-lactone 5-phosphate [CPD:C22034];
H2O [CPD:C00001];
L-arabino-1,4-lactone 5-phosphate [CPD:C22036]

Product

5-phospho-D-xylonate [CPD:C22035];
5-phospho-L-arabinate [CPD:C22037]

Comment

The enzyme, characterized from Mycoplasma spp., contains a binuclear metal center with two zinc cations. The enzyme is specific for the phosphorylated forms, and is unable to hydrolyse non-phosphorylated 1,4-lactones.

History

EC 3.1.1.104 created 2018

Orthology

K23149

5-phospho-D-xylono-1,4-lactonase

Genes

ENF:	AKI40_3139

KOX:

KOX_20855

KOE:

A225_3033

KOM:	HR38_19150

KOK:	KONIH1_14895

KOC:	AB185_21050

KLL:	BJF97_15080

KLW:	DA718_14585

KGR:	JJJ10_13880

KPAS:

LUW96_21480

KLC:	K7H21_14615

KLM:	BWI76_14780

RTG:	NCTC13098_03643(php)

KOO:	O9K67_12505

AHN:	NCTC12129_02540(php)

ASUB:

NLZ15_10940

SFW:	WN53_15210

SFO:	Z042_08460

SOD:

Sant_2195

PTRO:

G5S35_35665

DEA:	FPZ08_19085

MAAD:

AZF01_19095

MLUT:

JET14_19970

BCIR:

C2I06_15540

BMH:	BMWSH_3190

BHA:

BH0225

OJD:	NP439_20560

GTK:	GT3570_09910

GWC:	GWCH70_1411

GYC:	GYMC61_2929

GYA:	GYMC52_2058

PCAL:

BV455_00343

PARG:

PspKH34_23250

ANM:	GFC28_1630

ANL:	GFC29_3804

AND:	GRQ40_04765

LAGR:

FJQ98_07330 FJQ98_10055

LMAC:

I6G82_12020

VIG:	BKP57_10630 BKP57_16535

VPN:	A21D_02505

VPT:	KBP50_00160 KBP50_13415

LAO:	AOX59_03770

PSYB:

KD050_15500

SALE:

EPH95_03720

MSEM:

GMB29_22465

SEDD:

ERJ70_15945

BOU:	I5818_03850

PUK:	PU629_03075

LMO:	lmo1970 lmo2648

LMN:	LM5578_0212 LM5578_2171

LMY:	LM5923_0212 LM5923_2122

LMT:	LMRG_01117 LMRG_02193

LMOC:

LMOSLCC5850_2032 LMOSLCC5850_2660

LMOE:

BN418_2361 BN418_3129

LMOB:

BN419_2363 BN419_3141

LMOD:

LMON_2041 LMON_2671

LMOW:

AX10_04090 AX10_07385

LMOQ:

LM6179_00059 LM6179_02740

LMR:	LMR479A_2080 LMR479A_2783

LMOM:

IJ09_11500 IJ09_15365

LMF:	LMOf2365_2620

LMC:	Lm4b_02614

LMOG:

BN389_26070

LMP:

MUO_13220

LMOL:

LMOL312_2607

LMOJ:

LM220_16622

LMOZ:

LM1816_02247

LMOX:

AX24_11255

LMH:	LMHCC_2886

LMQ:

LMM7_2760

LML:	lmo4a_2712

LMG:	LMKG_00359 LMKG_03009

LMS:	LMLG_0461 LMLG_1268

LMJ:	LMOG_01266 LMOG_01862

LMW:	LMOSLCC2755_2661

LMX:	LMOSLCC2372_2036 LMOSLCC2372_2714

LMZ:	LMOSLCC2482_2660

LMON:

LMOSLCC2376_2545

LMOS:

LMOSLCC7179_1942 LMOSLCC7179_2618

LMOO:

LMOSLCC2378_2650

LMOY:

LMOSLCC2479_2033 LMOSLCC2479_2714

LMOT:

LMOSLCC2540_2688

LMOA:

LMOATCC19117_2657

LMOK:

CQ02_13470

LMV:	Y193_02370

LIN:

lin2797

LWE:

lwe2597

LSG:

lse_2552

LIV:

LIV_2559

LII:	JL52_13500

LIW:	AX25_13705

LIA:	JL58_13730

LIO:	JL53_14170

LMAR:

LAX80_012910

BHUI:

LOK74_04535

GYM:	GYMC10_4834

POW:	IJ21_01040 IJ21_48420

PIB:	BBD41_01880

PVO:	PVOR_18344

PLW:	D5F53_05945

PLUT:

EI981_16445

PCHI:

PC41400_08250

PTHI:

NDS46_25515

PDY:	QJQ58_26605

PMAE:

LMZ02_30970

PSPN:

L1F29_15755

PKP:	SK3146_05453

ADAU:

NZD86_19365 NZD86_23700

NTR:	B0W44_08145 B0W44_16725

KEB:	GXN75_05840

LKL:	DKL58_04825

LCL:	LOCK919_0418

LZE:	KG087_01740

EAV:	EH197_05570

ACG:	AWM71_03805

HHJ:	NQ487_04785 NQ487_21590

FPLA:

A4U99_17820

PETR:

QKW49_19540 QKW49_22375

CFEM:

HCR03_00145

STH:

STH554

CMIC:

caldi_06960

ROB:

CK5_19980

BHV:	BLHYD_31450

CHYL:

CE91St63_13670

ARF:	AR1Y2_2852

ACAC:

EYQ97_04045

WHJ:	H9Q79_11500

CMIU:

B1H56_03045

TEP:	TepRe1_2016

TAE:	TepiRe1_2173

BACG:

D2962_03490

HHL:	Halha_0786

SPOA:

EQM13_05590

MTAU:

JS510_02840

MIGU:

NV226_01055

SCLA:

SCLARK_001372

SCHI:

SCHIN_v1c08130

MHY:

mhp389

MHJ:

MHJ_0373

MHP:	MHP7448_0377

MHN:	MHP168_419

MHYL:

MHP168L_419

MHYO:

MHL_1423

MCO:	MCJ_003290

MHR:

MHR_0460

MHH:

MYM_0485

MHM:

SRH_03585

MHS:

MOS_520

MHV:

Q453_0522

MFQ:

MYF_01500

MDS:	MDIS_01885

MNU:	NCTC10166_00011

MOE:	NCTC10151_00584

MMOL:

NX772_00755

MLAG:

QEG99_02930

MGB:	VO56_00565

MGLY:

NCTC10194_00462

MPU:	MYPU_5930(MYPU_5930)

MSY:

MS53_0025

MSO:	VY93_00150

MAA:

MAG6390

MAL:

MAGa7350

MFR:

MFE_00350

MFM:	MfeM64YM_0028

MFP:

MBIO_0658

MBV:	MBOVPG45_0738

MBH:

MMB_0685

MBI:

Mbov_0724

MBQ:	K668_03420

MCY:	MCYN_0239(MCYN0239)

MGAL:

NCTC10186_00569

MCIT:

NCTC10181_00028

MCAV:

NPA07_05320

MEQI:

NPA09_01480

MPN:

MPN_497

MPM:

MPNA4970

MPB:	C985_01205

MFD:	NPA10_02895

MPE:	MYPE7240(MYPE7240)

OLS:

Olsu_0016

ERZ:	ER308_14515

CGS:	C624_06205 C624_06210

CGG:	C629_06205 C629_06210

CHN:	A605_05210

CPHO:

CPHO_02670

NOD:	FOH10_13705

RHB:

NY08_873

RCR:	NCTC10994_00393(opd_2)

RKO:	JWS14_29035

RGO:	KYT97_18940

GTA:	BCM27_14830

SCO:	SCO1036(SCG20A.16)

SMA:	SAVERM_1441

SHY:

SHJG_2502

SHO:	SHJGH_2266

SFA:

Sfla_5771

SBH:

SBI_09288

STRP:

F750_0814

SLV:	SLIV_32610

STRE:

GZL_07336

SCW:	TU94_03900

SLD:

T261_6934

SLC:	SL103_12815

STRC:

AA958_27395

SCZ:	ABE83_32575

SCX:	AS200_39165

SRW:	TUE45_01400

SLE:	sle_60670(sle_60670)

STRT:

A8713_03415

SGS:	AVL59_29800

STSI:

A4E84_04590

SALW:

CP975_04035

SLS:	SLINC_0963

SNR:	SNOUR_33465

SALU:

DC74_1809

SALL:

SAZ_09625

STRD:

NI25_33995

SSIA:

A7J05_30975

SPUN:

BFF78_37065

SGV:	B1H19_08565

SALF:

SMD44_00848

SALJ:

SMD11_6417

STRO:

STRMOE7_07285

SFK:

KY5_0854

SGE:	DWG14_07652(php)

SRJ:

SRO_6508

SDX:	C4B68_36230

SCYA:

EJ357_41890

SKA:	CP970_38705

SNK:	CP967_31760

SHAW:

CEB94_05080

SVR:	CP971_05975

SPAD:

DVK44_01260

SAQU:

EJC51_07280

SGF:	HEP81_06852

SCAV:

CVT27_02030

SRIM:

CP984_34780

SCHA:

CP983_38905

SCOE:

CP976_04540

SBAT:

G4Z16_07610

SSPB:

CP982_38000

SPLA:

CP981_05870

SBRO:

GQF42_06880

STUI:

GCM10017668_63790

SHUN:

DWB77_06582(php)

SCYG:

S1361_05430

SDW:	K7C20_05505

SAUH:

SU9_004505

SMOB:

J7W19_02660

SROI:

IAG44_05130

SXN:	IAG42_31875

SHK:	J2N69_03980

SDD:	D9753_31680

SACT:

DMT42_04055

SMAO:

CAG99_16140

SINE:

KI385_08660 KI385_38830

SLF:	JEQ17_42675

SAOV:

G3H79_34095

SDUR:

M4V62_36970

SNIG:

HEK616_21920

STUB:

MMF93_24715

SSPN:

LXH13_03705

SLON:

LGI35_08440

SDRZ:

NEH16_28625

STUD:

STRTU_006124

SYUN:

MOV08_33965

SARG:

HKX69_30945

SJN:	RI060_38770

SCYN:

N8I84_36040

SOV:	QZH56_33725

SHAU:

K9S39_25870

SKG:	KJK29_35820

SCOA:

QU709_41225

SLAI:

P8A22_35385

SFP:	QUY26_36205

SINN:

ABB07_33570

SCT:

SCAT_1545

SCY:	SCATT_15470

KAU:	B6264_01175

KIT:	CFP65_6282

STRH:

GXP74_38130

ABRY:

NYE86_14320

TWH:	TWT_650(php)

TWS:

TW672

LXY:	O159_25590

LEIF:

HF024_16730

CMI:

CMM_0542

MTS:

MTES_1124

MIM:	AKG07_10840

MIX:	AB663_000457

MIP:	AXH82_04460

MPAL:

BO218_11585

MICR:

BMW26_15580

MFOL:

DXT68_15000

MWA:	E4K62_09260

MSED:

E3O41_04335

MOY:	CVS54_03323(php)

MCHN:

HCR76_16380

MICS:

C1N74_15445

MLIQ:

NMQ05_16030

MPAO:

IZR02_14910

MELY:

L2X98_27555

MNF:	JSY13_11285

MEST:

PTQ19_13845

FRP:	AX769_09265

AGF:	ET445_10680

AARC:

G127AT_06040

SALC:

C2138_02820

HUW:	FPZ11_01125

PLAP:

EAO79_06605

LALL:

MUN78_03300

HEA:	HL652_20370

AGX:	AGREI_2031

ARN:	CGK93_22120

BRZ:	CFK38_11635

CXIE:

NP048_00845

SERW:

FY030_14425

PAC:

PPA0879

PAK:	HMPREF0675_3936

PAV:	TIA2EST22_04380

PAX:	TIA2EST36_04350

PAZ:	TIA2EST2_04300

PAW:	PAZ_c09150

PAD:	TIIST44_10255

PCN:	TIB1ST10_04545

PACC:

PAC1_04655

PACH:

PAGK_1270

PACN:

TIA1EST1_04320

CACN:

RN83_04765

PRA:	PALO_06665

PRL:	BCB70_00860

CEQU:

O6R08_03890

PACD:

EGX94_01620

PAUS:

NCTC13651_00913

PPC:	HMPREF9154_1159

PRV:	G7070_13955

KQI:	F1D05_19635

KSL:	OG809_10530

ACTW:

F7P10_05300

ACIR:

OG979_17840

ACTQ:

OG417_46215 OG417_52850

SRO:

Sros_2491

MHAI:

OHB01_36730

ACE:

Acel_0570

NML:

Namu_1523

AMD:

AMED_4921

AMN:

RAM_25050

AMM:

AMES_4862

AMZ:

B737_4862

APRT:

MUY14_13020

ARHD:

VSH64_13350

KAL:

KALB_2148

KUT:	JJ691_25680

KBU:	Q4V64_49700

MCRA:

ID554_30675

MPRN:

Q3V37_19275

AIH:	Aiant_54560

AOU:	ACTOB_001075

PLAB:

C6361_30510

PLAT:

C6W10_35590

PFLA:

Pflav_028930

ASER:

Asera_50630

CAI:

Caci_2395

ASG:	FB03_07190

AUU:	CJ184_001165

ATIM:

CYJ17_0002870

ACTT:

DDD63_05295

ACTP:

B6G06_01785

ACTC:

CHIBA101_0539

AVC:	NCTC10951_02841

AMAM:

HPC72_08120

ACAP:

MANAM107_16040

ALIL:

D5R93_08270

WIK:	H8R18_00285

BCOR:

BCOR_1325

BII:	BINDI_1256

BSCA:

BBSC_0796

BACT:

AB656_05160

BSUE:

BS3272_02725

CWO:

Cwoe_2978

CAP:	CLDAP_29710

THUG:

KNN16_07550

SDYN:

Mal52_43850(opd)

PCOR:

KS4_19500

STR:	Sterm_0217 Sterm_2488 Sterm_3191

HHY:	Halhy_6821

SPIR:

CWM47_02725

SENF:

GJR95_37325

RHOZ:

GXP67_35405

RSI:	Runsl_4738

FAE:	FAES_2377(php)

PPSV:

PEPS_35160

MART:

BTR34_13640

AALG:

AREALGSMS7_00436

MLT:

VC82_1986

» show all

Reference

1 [PMID:24955762]

Authors

Korczynska M, Xiang DF, Zhang Z, Xu C, Narindoshvili T, Kamat SS, Williams HJ, Chang SS, Kolb P, Hillerich B, Sauder JM, Burley SK, Almo SC, Swaminathan S, Shoichet BK, Raushel FM

Title

Functional annotation and structural characterization of a novel lactonase hydrolyzing D-xylono-1,4-lactone-5-phosphate and L-arabino-1,4-lactone-5-phosphate.

Journal

Biochemistry 53:4727-38 (2014)
DOI:10.1021/bi500595c

Sequence

[msy:MS53_0025] [maa:MAG6390]

Other DBs

ExplorEnz - The Enzyme Database:

3.1.1.104

IUBMB Enzyme Nomenclature:

3.1.1.104

ExPASy - ENZYME nomenclature database:

3.1.1.104

BRENDA, the Enzyme Database:

3.1.1.104

All links

Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (3)   
   KEGG REACTION (2)   
   KEGG RCLASS (1)   
Gene (1172)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (427)   
   KEGG MGENES (744)   
Protein sequence (4)   
   UniProt (2)   
   SWISS-PROT (2)   
Protein domain (2)   
   InterPro (2)   
All databases (1186)   

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