KEGG ENZYME: 3.1.1.105

ENZYME: 3.1.1.105

Entry

EC 3.1.1.105                Enzyme

Name

3-O-acetylpapaveroxine carboxylesterase;
CXE1 (gene name)

Class

Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases

Sysname

3-O-acetylpapaveroxine acetatehydrolase

Reaction(IUBMB)

3-O-acetylpapaveroxine + H2O = narcotine hemiacetal + acetate [RN:R12347]

Reaction(KEGG)

R12347;
(other) R11693 R11694

Substrate

3-O-acetylpapaveroxine [CPD:C21591];
H2O [CPD:C00001]

Product

narcotine hemiacetal [CPD:C20297];
acetate [CPD:C00033]

Comment

The enzyme, characterized from the plant Papaver somniferum (opium poppy), participates in the biosynthesis of the isoquinoline alkaloid noscapine.

History

EC 3.1.1.105 created 2019

Pathway

ec00950

Isoquinoline alkaloid biosynthesis

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K22097

3-O-acetylpapaveroxine carboxylesterase

Genes

PSOM:

113322812 113323289

Reference

1 [PMID:25485687]

Authors

Dang TT, Chen X, Facchini PJ

Title

Acetylation serves as a protective group in noscapine biosynthesis in opium poppy.

Journal

Nat Chem Biol 11:104-6 (2015)
DOI:10.1038/nchembio.1717

Reference

2 [PMID:29723437]

Authors

Park MR, Chen X, Lang DE, Ng KKS, Facchini PJ

Title

Heterodimeric O-methyltransferases involved in the biosynthesis of noscapine in opium poppy.

Journal

Plant J 95:252-267 (2018)
DOI:10.1111/tpj.13947

Other DBs

ExplorEnz - The Enzyme Database:

3.1.1.105

IUBMB Enzyme Nomenclature:

3.1.1.105

ExPASy - ENZYME nomenclature database:

3.1.1.105

BRENDA, the Enzyme Database:

3.1.1.105

DBGET integrated database retrieval system