Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
BRITE hierarchy

iron(III)-enterobactin hydrolase

iron(III)-enterobactin + 3 H2O = iron(III)-N-(2,3-dihydroxybenzoyl)-L-serine complex + 2 N-(2,3-dihydroxybenzoyl)-L-serine (overall reaction);
(1a) iron(III)-enterobactin + H2O = iron(III)-N-(2,3-dihydroxybenzoyl)-L-serine trimer complex;
(1b) iron(III)-N-(2,3-dihydroxybenzoyl)-L-serine trimer complex + H2O = iron(III)-N-(2,3-dihydroxybenzoyl)-L-serine dimer complex + N-(2,3-dihydroxybenzoyl)-L-serine;
(1c) iron(III)-N-(2,3-dihydroxybenzoyl)-L-serine dimer complex + H2O = iron(III)-N-(2,3-dihydroxybenzoyl)-L-serine complex + N-(2,3-dihydroxybenzoyl)-L-serine

iron(III)-enterobactin;
H2O [CPD:C00001];
iron(III)-N-(2,3-dihydroxybenzoyl)-L-serine trimer complex;
iron(III)-N-(2,3-dihydroxybenzoyl)-L-serine dimer complex

The enzyme, isolated from the bacterium Escherichia coli, allows the bacterium to grow in limited iron conditions. It can also act on enterobactin (with no complexed iron) and the aluminium(III) analogue of iron(III)-enterobactin. The trimer formed is further hydrolysed to form the dimer and the monomer.

EC 3.1.1.108 created 2019

1  [PMID:4330269]

2  [PMID:150859]

3  [PMID:3040679]

4  [PMID:1534808]

5  [PMID:8148617]

6  [PMID:30086222]