Entry
Name
lipoprotein lipase;
clearing factor lipase;
diacylglycerol lipase;
postheparin esterase;
diglyceride lipase;
postheparin lipase;
diacylglycerol hydrolase;
lipemia-clearing factor;
hepatic triacylglycerol lipase;
LIPC (gene name);
LPL (gene name);
triacylglycero-protein acylhydrolase
Class
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
BRITE hierarchy
Sysname
triacylglycerol acylhydrolase (lipoprotein-dependent)
Reaction(IUBMB)
triacylglycerol + H2O = diacylglycerol + a carboxylate [RN:
R01369 ]
Reaction(KEGG)
Substrate
Product
Comment
Hydrolyses triacylglycerols and diacylglycerol in chylomicrons and low-density lipoprotein particles. Human protein purified from post-heparin plasma (LPL) shows no activity against triglyceride in the absence of added lipoprotein. The principal reaction sequence of that enzyme is triglyceride -> 1,2-diglyceride -> 2-monoglyceride. The hepatic enzyme (LIPC) also hydrolyses triglycerides and phospholipids present in circulating plasma lipoproteins.
History
EC 3.1.1.34 created 1972, modified 1976
Pathway
Orthology
Genes
XLA : 108706825(lpl.S) 108712233(lpl.L)
DRE : 100331214 101884800 30354(lpla)
SRX : 107715086 107715087 107750918 107754598 107757476
SANH : 107653621 107665504 107665505 107687910 107696683
SGH : 107552720 107561901 107561902 107588077 107588078 107596239
CCAR : 109046620 109046622 109046956 109090420
CAUA : 113040150 113040152 113040163 113040164 113045264 113064829
CGIB : 127943264 127951104 127987964 127988557
PTET : 122327622(lpl) 122327703 122335600 122335639
LROH : 127151951 127153695(lpl) 127153705
OMC : 131529655 131530698 131530855(lpla)
PPRM : 120474930 120486228 120486532(lpl)
RKG : 130089313 130089314(lpla) 130105608
MAMB : 125251126(lpl) 125251135 125251306
CIDE : 127504425 127520834 127520835
MASI : 127437929 127439043 127439070 127441440 127442516
TROS : 130548347(lpla) 130548348 130554017
TDW : 130418116 130429638(lpla) 130429639
MANU : 129452756 129452757(lpla)
IPU : 108271131(lpl) 108280930
IFU : 128613941(lpl) 128624287
PHYP : 113533484 113536621 113536692
SMEO : 124391426 124391471(lpl) 124403364
TFD : 113645101 113650786 113650790(lpl)
TVC : 132845186 132854348(lpla) 132854369
AMEX : 103021581 103042854 103043174
CMAO : 118797146 118818927 118819290(lpl)
EEE : 113574503 113574524 113582888
CHAR : 105900970 105900971(lpl) 122130758
TRU : 101062428(lpl) 101068642
TFS : 130528583(lpla) 130528584
TNG : GSTEN00028798G001 GSTEN00028799G001
TBEN : 117495640(lpl) 117495645
CGOB : 115006849(lpl) 115007104
PGEO : 117445278(lpl) 117445700
GACU : 117541117(lpl) 117541127
ELY : 117254214 117254432(lpl)
EFO : 125895494(lpl) 125895495
PLEP : 121937831(lpl) 121937842
SLUC : 116055229 116055317(lpl)
ECRA : 117951001(lpl) 117951002
ESP : 116695129(lpl) 116695130
PFLV : 114561073 114561172
GAT : 120824060(lpl) 120824184
PPUG : 119216356(lpl) 119216357
AFB : 129094241(lpla) 129095061
CLUM : 117729846(lpl) 117730019
MSAM : 119900751 119900754(lpl)
SCHU : 122877663(lpl) 122877698
CUD : 121512160 121512162(lpl)
ALAT : 119028769 119028900(lpl)
ONL : 100534504(lpl) 100689908
OAU : 116309207(lpl) 116309219
OLA : 101160309(lpl) 101160547
OML : 112150410(lpl) 112150654
XCO : 114150801 114151199(lpl)
PRET : 103463532 103463534(lpl)
PFOR : 103156884(lpl) 103156885
PLAI : 106955285(lpl) 106955287
PMEI : 106928981(lpl) 106929061
GAF : 122838476(lpl) 122838503
PPRL : 129374617 129376840(lpla)
CTUL : 119780851(lpl) 119780853
GMU : 124873925 124874261(lpl)
NFU : 107393172 107393174(lpl)
KMR : 108230795(lpl) 108230848
ALIM : 106521565(lpl) 106521567
NWH : 119407848 119430661(lpl)
AOCE : 111585084 111586565 111586568
MCEP : 125009575(lpl) 125009766
CSEM : 103397050 103397060(lpl)
POV : 109625830(lpl) 109625897
SSEN : 122780908 122781182(lpl)
HHIP : 117760249(lpl) 117760400
HSP : 118121010(lpl) 118121083
SDU : 111232066(lpl) 111232091
SLAL : 111654280(lpl) 111654288
XGL : 120790626(lpl) 120790802
SSCV : 125973817 125973822
SBIA : 133503441(lpla) 133503873
PEE : 133406005 133406014(lpla)
PTAO : 133481408(lpla) 133481409
BSPL : 114853517(lpla) 114853518
SJO : 128362032(lpl) 128362033
SASA : 106569629 106573544 106573546 106613694 106613695
STRU : 115151752 115151753 115157543 115158162 115158163
OTW : 112224719 112250798 112250799 112252199
OMY : 100136622(lpl) 110501773 110501969 110524209 110530805
OGO : 123989645 123997140 123997141 123998873 124009783
ONE : 115108237 115108239 115109211 115109213 115117068
OKI : 109874575 109889187 109889188 109902437
OKE : 118375122(lpl) 118375123 118388846 118388857
SALP : 111952856 111952857 111975751 111975815
SNH : 120053767(lpl) 120054726 120054727 120056135
CCLU : 121533603 121533604 121535425 121576808 121577139
ELS : 105011471 105011473(lpl) 105022495
SFM : 108919920 108919924(lpl)
PKI : 111847582 111860378 111860417
AANG : 118225833 118226535(lpl) 118228878 118228901
PSPA : 121300697 121300855 121301421 121301562
ARUT : 117401417 117401443 117963032 117966368
PSEX : 120537800(lpl) 120537801
LCM : 102349247(LPL) 102362907
RTP : 109922304(lpl) 109922306
CPLA : 122565148 122565534
LERI : 129711216 129711217
CQU : CpipJ_CPIJ015386 CpipJ_CPIJ015387 CpipJ_CPIJ016050 CpipJ_CPIJ016051
» show all
Taxonomy
Reference
Authors
Egelrud T, Olivecrona T.
Title
Purified bovine milk (lipoprotein) lipase: activity against lipid substrates in the absence of exogenous serum factors.
Journal
Reference
Authors
Fielding CJ.
Title
Human lipoprotein lipase. I. Purification and substrate specificity.
Journal
Reference
Authors
Greten H, Levy RI, Fales H, Fredrickson DS.
Title
Hydrolysis of diglyceride and glyceryl monoester diethers with "lipoprotein lipase".
Journal
Reference
Authors
Morley N, Kuksis A.
Title
Positional specificity of lipoprotein lipase.
Journal
J Biol Chem 247:6389-93 (1972)
Reference
Authors
Nilsson-Ehle P, Belfrage P, Borgstrom B.
Title
Purified human lipoprotein lipase: positional specificity.
Journal
Reference
Authors
Santamarina-Fojo S, Gonzalez-Navarro H, Freeman L, Wagner E, Nong Z
Title
Hepatic lipase, lipoprotein metabolism, and atherogenesis.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 3.1.1.34
ExPASy - ENZYME nomenclature database: 3.1.1.34