Entry
Name
phosphatidylinositol deacylase;
phosphatidylinositol phospholipase A2;
phospholipase A2
Class
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
BRITE hierarchy
Sysname
1-phosphatidyl-D-myo-inositol 2-acylhydrolase
Reaction(IUBMB)
1-phosphatidyl-D-myo-inositol + H2O = 1-acylglycerophosphoinositol + a carboxylate [RN:
R03360 ]
Reaction(KEGG)
Substrate
1-phosphatidyl-D-myo-inositol [CPD:
C01194 ];
H2O [CPD:
C00001 ]
Product
1-acylglycerophosphoinositol [CPD:
C03819 ];
carboxylate [CPD:
C00060 ]
History
EC 3.1.1.52 created 1984
Pathway
ec00564 Glycerophospholipid metabolism
Reference
Authors
Gray NC, Strickland KP.
Title
The purification and characterization of a phospholipase A2 activity from the 106,000 X g pellet (microsomal fraction) of bovine brain acting on phosphatidylinositol.
Journal
Reference
Authors
Gray NC, Strickland KP.
Title
On the specificity of a phospholipase A2 purified from the 106,000 X g pellet of bovine brain.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 3.1.1.52
ExPASy - ENZYME nomenclature database: 3.1.1.52