Entry
Name
pimelyl-[acyl-carrier protein] methyl ester esterase;
BioH
Class
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
BRITE hierarchy
Sysname
pimeloyl-[acyl-carrier protein] methyl ester hydrolase
Reaction(IUBMB)
pimeloyl-[acyl-carrier protein] methyl ester + H2O = pimeloyl-[acyl-carrier protein] + methanol [RN:
R09725 ]
Reaction(KEGG)
Substrate
pimeloyl-[acyl-carrier protein] methyl ester [CPD:
C19846 ];
H2O [CPD:
C00001 ]
Product
pimeloyl-[acyl-carrier protein] [CPD:
C19845 ];
methanol [CPD:
C00132 ]
Comment
Involved in biotin biosynthesis in Gram-negative bacteria. The enzyme exhibits carboxylesterase activity, particularly toward substrates with short acyl chains [1,2]. Even though the enzyme can interact with coenzyme A thioesters [3], the in vivo role of the enzyme is to hydrolyse the methyl ester of pimeloyl-[acyl carrier protein], terminating the part of the biotin biosynthesis pathway that is catalysed by the fatty acid elongation enzymes [4].
History
EC 3.1.1.85 created 2011
Pathway
Orthology
K02170 pimeloyl-[acyl-carrier protein] methyl ester esterase
K09789 pimeloyl-[acyl-carrier protein] methyl ester esterase
K19560 pimeloyl-[acyl-carrier protein] methyl ester esterase
K19561 pimeloyl-[acyl-carrier protein] methyl ester esterase
Genes
ECOO : ECRM13514_4360(bioH)
ECOH : ECRM13516_4156(bioH)
EDJ : ECDH1ME8569_3291(bioH)
ECOI : ECOPMV1_03719(bioH)
REE : electrica_00321(bioH)
CLAP : NCTC11466_00152(bioH)
KIE : NCTC12125_04239(bioH)
AHN : NCTC12129_00367(bioH)
METY : MRY16398_03840(bioH)
PSHI : SAMEA2665130_0190(bioH)
YPG : YpAngola_A3748(bioH)
YPI : YpsIP31758_3988(bioH)
SMW : SMWW4_v1c45840(bioH)
SFJ : SAMEA4384070_4589(bioH)
SOF : NCTC11214_01389(bioH)
SERA : Ser39006_000675(bioH)
PAQU : DMB82_0018890(bioH)
DIC : Dpoa569_000332(bioH)
TPTY : NCTC11468_00064(bioH)
PHEI : NCTC12003_00273(bioH)
PRJ : NCTC6933_00287(bioH)
LRI : NCTC12151_00237(bioH)
HAEG : NCTC8502_01528(bioD_1)
XFU : XFF4834R_chr03710(bioH)
XPH : XppCFBP6546_09890(bioH)
XHD : LMG31886_04340(bioH)
LEZ : GLE_0063(bioH) GLE_1133
LHX : LYSHEL_12750(bioH_1)
LCAS : LYSCAS_12750(bioH_1)
LLZ : LYB30171_00097(bioH)
VAU : VANGNB10_cI0170(bioH)
VPL : SA104470976_00114(bioH)
PAEB : NCGM1900_0513(bioH)
PCQ : PcP3B5_06320(bioH_1)
PFL : PFL_3106 PFL_5691(bioH)
PPRC : PFLCHA0_c31370 PFLCHA0_c56420(bioH)
PMUD : NCTC8068_04914(bioH)
PFW : PF1751_v1c50400(bioH)
PPUU : PputUW4_04981(bioH)
PSOS : POS17_3110 POS17_5621
PTAE : NCTC10697_00424(bioH)
MARI : ACP86_02785 ACP86_06990
SCAA : TUM17387_38640(bioH)
SALH : HMF8227_00088(bioH)
PMAW : MACH26_00920(bioH_1)
LLG : 44548918_01422(bioH)
LJR : NCTC11533_01412(bioH_1)
LCJ : NCTC11976_02353(bioH)
LWA : SAMEA4504053_1709(bioH)
LSS : NCTC12082_00522(bioH_1)
LADL : NCTC12735_00761(bioH)
MISZ : MishRS11D_04700(bioH)
TSE : THMIRHAS_01710(bioH)
TZO : THMIRHAT_01990(bioH)
TFRI : Thiofri_03794(bioH)
TNI : TVNIR_0191(bioH_[H])
THIC : TspCOW1_26760(bioH)
KUS : B9G99_04955 B9G99_12685
KMA : B9H00_02305 B9H00_10215
ALCA : ASALC70_01670(bioH)
AEL : NCTC12917_04034(bioH)
CDIZ : CEDIAZO_00638(bioH)
NMH : NMBH4476_0264(bioH) NMBH4476_0466
NMD : NMBG2136_0270(bioH) NMBG2136_1627
NMM : NMBM01240149_1617 NMBM01240149_1817(bioH)
NMS : NMBM01240355_0274(bioH) NMBM01240355_0481
NMQ : NMBM04240196_0276(bioH) NMBM04240196_0480
NMZ : NMBNZ0533_0271(bioH) NMBNZ0533_1778
NMW : NMAA_1467 NMAA_1709(bioH)
NMX : NMA510612_2263 NMA510612_2523
NMT : NMV_0295(bioH) NMV_0520
NWE : SAMEA3174300_1728(bioH)
NFV : FAH67_07735 FAH67_09590(bioH)
NBL : GJV52_03430 GJV52_05210(bioH)
NZO : SAMEA4504057_0254(bioH)
NCI : NCTC10296_00728(bioH)
NCZ : NCTC10294_01505(bioH)
NANI : NCTC12227_01921(bioH_2)
NSG : H3L94_00640 H3L94_10040(bioH)
ECOR : SAMEA4412678_2100(bioH)
PLG : NCTC10937_00563(bioH)
BTRM : SAMEA390648704141(bioH)
AXX : ERS451415_04621(bioH)
FKU : FGKAn22_03550(bioH_1)
URU : DSM104443_00710(bioH)
UPL : DSM104440_00666(bioH)
FPHO : SHINM1_004030(bioH)
BRD : JL11_02435 JL11_16440
BMED : GYM46_06350 GYM46_11115
BVY : NCTC9239_02478(bioH_1)
LAQU : R2C4_03420 R2C4_05585
GBN : GEOBRER4_32990(bioH)
COHN : KCTCHS21_53470(bioH)
BEG : INE88_04146 INE88_04147(bioC)
BSTE : K6V31_03945 K6V31_03950(bioC)
BHUM : JXR92_014325 JXR92_014330(bioC)
» show all
Taxonomy
Reference
Authors
Sanishvili R, Yakunin AF, Laskowski RA, Skarina T, Evdokimova E, Doherty-Kirby A, Lajoie GA, Thornton JM, Arrowsmith CH, Savchenko A, Joachimiak A, Edwards AM
Title
Integrating structure, bioinformatics, and enzymology to discover function: BioH, a new carboxylesterase from Escherichia coli.
Journal
Sequence
Reference
Authors
Lemoine Y, Wach A, Jeltsch JM
Title
To be free or not: the fate of pimelate in Bacillus sphaericus and in Escherichia coli.
Journal
Reference
Authors
Tomczyk NH, Nettleship JE, Baxter RL, Crichton HJ, Webster SP, Campopiano DJ
Title
Purification and characterisation of the BIOH protein from the biotin biosynthetic pathway.
Journal
Sequence
Reference
Authors
Lin S, Hanson RE, Cronan JE
Title
Biotin synthesis begins by hijacking the fatty acid synthetic pathway.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.1.1.85
ExPASy - ENZYME nomenclature database: 3.1.1.85