KEGG   ENZYME: 3.1.1.90
Entry
EC 3.1.1.90                 Enzyme                                 
Name
all-trans-retinyl ester 13-cis isomerohydrolase
Class
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
Sysname
all-trans-retinyl ester acylhydrolase, 13-cis-retinol-forming
Reaction(IUBMB)
an all-trans-retinyl ester + H2O = 13-cis-retinol + a fatty acid [RN:R09826]
Reaction(KEGG)
R09826
Substrate
all-trans-retinyl ester [CPD:C02075];
H2O [CPD:C00001]
Product
13-cis-retinol [CPD:C19962];
fatty acid [CPD:C00162]
Comment
All-trans-retinyl esters, which are a storage form of vitamin A, are generated by the activity of EC 2.3.1.135, phosphatidylcholine---retinol O-acyltransferase (LRAT). They can be hydrolysed to 11-cis-retinol by EC 3.1.1.64, retinoid isomerohydrolase (RPE65), or to 13-cis-retinol by this enzyme.
History
EC 3.1.1.90 created 2011
Orthology
K20991  all-trans-retinyl ester 13-cis isomerohydrolase
Genes
DRE: 100002865(rpe65b)
Reference
1  [PMID:21235714]
  Authors
Takahashi Y, Moiseyev G, Chen Y, Farjo K, Nikolaeva O, Ma JX
  Title
An enzymatic mechanism for generating the precursor of endogenous 13-cis retinoic acid in the brain.
  Journal
FEBS J 278:973-87 (2011)
DOI:10.1111/j.1742-4658.2011.08019.x
  Sequence
[dre:100002865]
Other DBs
ExplorEnz - The Enzyme Database: 3.1.1.90
IUBMB Enzyme Nomenclature: 3.1.1.90
ExPASy - ENZYME nomenclature database: 3.1.1.90
BRENDA, the Enzyme Database: 3.1.1.90

  All links  
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (3)   
   KEGG REACTION (1)   
   KEGG RCLASS (2)   
Gene (2)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
Protein sequence (6)   
   UniProt (2)   
   SWISS-PROT (2)   
   RefSeq(pep) (2)   
DNA sequence (2)   
   RefSeq(nuc) (2)   
Protein domain (1)   
   InterPro (1)   
All databases (18)   

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