KEGG ENZYME: 3.1.1.94

ENZYME: 3.1.1.94

Entry

EC 3.1.1.94                 Enzyme

Name

versiconal hemiacetal acetate esterase;
VHA esterase

Class

Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases

Sysname

versiconal-hemiacetal-acetate O-acetylhydrolase

Reaction(IUBMB)

(1) versiconal hemiacetal acetate + H2O = versiconal + acetate [RN:R10401];
(2) versiconol acetate + H2O = versiconol + acetate [RN:R10398]

Reaction(KEGG)

R10398 R10401

Substrate

versiconal hemiacetal acetate [CPD:C20505];
H2O [CPD:C00001];
versiconol acetate [CPD:C20506]

Product

versiconal [CPD:C20507];
acetate [CPD:C00033];
versiconol [CPD:C20508]

Comment

Isolated from the mold Aspergillus parasiticus. Involved in a metabolic grid that leads to aflatoxin biosynthesis.

History

EC 3.1.1.94 created 2013

Pathway

ec00254

Aflatoxin biosynthesis

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K17648

versiconal hemiacetal acetate esterase

Genes

PAN:	PODANSg8561

PBEL:

QC761_207320

PPSD:

QC762_207320

PPSP:

QC763_207320

PPSA:

QC764_207320

MTM:	MYCTH_54712

PGRI:

PgNI_02164

FGR:	FGSG_09112

FVR:	FVEG_03630 FVEG_07643

FOX:	FOXG_04573 FOXG_05758

NHE:	NECHADRAFT_44040

FFC:	NCS54_00871400

FKR:	NCS57_00911800

FMU:	J7337_003641 J7337_010341

PTKZ:

JDV02_003531

SAPO:

SAPIO_CDS0298 SAPIO_CDS8256

SSL:	SS1G_01703

BFU:	BCIN_02g03480

MBE:

MBM_02254

PSCO:

LY89DRAFT_594986

GLZ:	GLAREA_08109

ANI:	ANIA_05565 ANIA_07816

ACT:	ACLA_062700

AOR:	AO090026000017

ANG:	An11g08610

AFV:	AFLA_006302

APUU:

APUU_10059S APUU_20047S

PCS:	N7525_004428

PNO:	SNOG_09866

PTE:

PTT_13757

BZE:	COCCADRAFT_3427

BSC:	COCSADRAFT_131207

BOR:	COCMIDRAFT_32193

AALT:

CC77DRAFT_1033655

ZTR:	MYCGRDRAFT_77854

PFJ:	MYCFIDRAFT_42424 MYCFIDRAFT_49459

FFU:	CLAFUR5_14256

CBET:

CB0940_05528 CB0940_05991

BCOM:

BAUCODRAFT_148152 BAUCODRAFT_307726

» show all

Reference

1 [PMID:8776851]

Authors

Kusumoto K, Hsieh DP

Title

Purification and characterization of the esterases involved in aflatoxin biosynthesis in Aspergillus parasiticus.

Journal

Can J Microbiol 42:804-10 (1996)
DOI:10.1139/m96-101

Reference

2 [PMID:15184162]

Authors

Chang PK, Yabe K, Yu J

Title

The Aspergillus parasiticus estA-encoded esterase converts versiconal hemiacetal acetate to versiconal and versiconol acetate to versiconol in aflatoxin biosynthesis.

Journal

Appl Environ Microbiol 70:3593-9 (2004)
DOI:10.1128/AEM.70.6.3593-3599.2004

Sequence

[ag:AAS66011]

Other DBs

ExplorEnz - The Enzyme Database:

3.1.1.94

IUBMB Enzyme Nomenclature:

3.1.1.94

ExPASy - ENZYME nomenclature database:

3.1.1.94

BRENDA, the Enzyme Database:

3.1.1.94

DBGET integrated database retrieval system