| Entry |
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| Name |
aclacinomycin methylesterase;
RdmC;
aclacinomycin methyl esterase
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| Class |
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
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| Sysname |
aclacinomycin T acylhydrolase
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| Reaction(IUBMB) |
aclacinomycin T + H2O = 15-demethylaclacinomycin T + methanol [RN: R10545]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
15-demethylaclacinomycin T [CPD: C20689];
methanol [CPD: C00132]
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| Comment |
The enzyme is involved in the modification of the aklavinone skeleton in the biosynthesis of anthracyclines in Streptomyces species.
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| History |
EC 3.1.1.95 created 2013
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| Pathway |
| ec01057 | Biosynthesis of type II polyketide products |
| ec01110 | Biosynthesis of secondary metabolites |
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| Orthology |
| K15957 | aclacinomycin methylesterase |
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| Genes |
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| Reference |
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| Authors |
Wang Y, Niemi J, Airas K, Ylihonko K, Hakala J, Mantsala P |
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| Title |
Modifications of aclacinomycin T by aclacinomycin methyl esterase (RdmC) and aclacinomycin-10-hydroxylase (RdmB) from Streptomyces purpurascens. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Jansson A, Niemi J, Mantsala P, Schneider G |
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| Title |
Crystal structure of aclacinomycin methylesterase with bound product analogues: implications for anthracycline recognition and mechanism. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 3.1.1.95 |
| ExPASy - ENZYME nomenclature database: | 3.1.1.95 |
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