KEGG   ENZYME: 3.1.2.16
Entry
EC 3.1.2.16                 Enzyme                                 
Name
citrate-lyase deacetylase;
[citrate-(pro-3S)-lyase] thiolesterase;
acetyl-S-(acyl-carrier protein) enzyme thioester hydrolase;
citrate lyase deacetylase;
[citrate-(pro-3S)-lyase](acetyl-form) hydrolase
Class
Hydrolases;
Acting on ester bonds;
Thioester hydrolases
Sysname
acetyl-[citrate-(pro-3S)-lyase] hydrolase
Reaction(IUBMB)
acetyl-[citrate (pro-3S)-lyase] + H2O = holo-[citrate (pro-3S)-lyase] + acetate [RN:R04450]
Reaction(KEGG)
R04450
Substrate
acetyl-[citrate (pro-3S)-lyase] [CPD:C04334];
H2O [CPD:C00001]
Product
holo-[citrate (pro-3S)-lyase] [CPD:C04298];
acetate [CPD:C00033]
Comment
In the proteobacterium Rubrivivax gelatinosus, this enzyme modulates the activity of EC 4.1.3.6, citrate (pro-3S)-lyase, by converting it from its active acetyl form into its inactive thiol form by removal of its acetyl groups [2]. The activity of citrate-lyase deacetylase is itself inhibited by L-glutamate [2].
History
EC 3.1.2.16 created 1989
Reference
1  [PMID:356]
  Authors
Giffhorn F, Gottschalk G.
  Title
Inactivation of citrate lyase from Rhodopseudomonas gelatinosa by a specific deacetylase and inhibition of this inactivation by L-(+1-glutamate.
  Journal
J Bacteriol 124:1052-61 (1975)
DOI:10.1128/JB.124.3.1052-1061.1975
Reference
2  [PMID:7460909]
  Authors
Giffhorn F, Rode H, Kuhn A, Gottschalk G.
  Title
Citrate lyase deacetylase of Rhodopseudomonas gelatinosa. Isolation of the enzyme and studies on the inhibition by L-glutamate.
  Journal
Eur J Biochem 111:461-71 (1980)
DOI:10.1111/j.1432-1033.1980.tb04961.x
Other DBs
ExplorEnz - The Enzyme Database: 3.1.2.16
IUBMB Enzyme Nomenclature: 3.1.2.16
ExPASy - ENZYME nomenclature database: 3.1.2.16
BRENDA, the Enzyme Database: 3.1.2.16
CAS: 58319-93-0

  All links  
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (3)   
   KEGG REACTION (1)   
   KEGG RCLASS (2)   
All databases (7)   

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