KEGG   ENZYME: 3.1.2.31
Entry
EC 3.1.2.31                 Enzyme                                 
Name
dihydromonacolin L-[lovastatin nonaketide synthase] thioesterase;
LovG
Class
Hydrolases;
Acting on ester bonds;
Thioester hydrolases
Sysname
dihydromonacolin L-[lovastatin nonaketide synthase] hydrolase
Reaction(IUBMB)
dihydromonacolin L-[lovastatin nonaketide synthase] + H2O = holo-[lovastatin nonaketide synthase] + dihydromonacolin L acid
Reaction(KEGG)
(other) R11187
Substrate
dihydromonacolin L-[lovastatin nonaketide synthase];
H2O [CPD:C00001]
Product
holo-[lovastatin nonaketide synthase];
dihydromonacolin L acid [CPD:C20851]
Comment
Dihydromonacolin L acid is synthesized while bound to an acyl-carrier protein domain of the lovastatin nonaketide synthase (EC 2.3.1.161). Since that enzyme lacks a thioesterase domain, release of the dihydromonacolin L acid moiety from the polyketide synthase requires this dedicated enzyme.
History
EC 3.1.2.31 created 2015
Pathway
ec00997  Biosynthesis of various other secondary metabolites
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K20985  dihydromonacolin L-[lovastatin nonaketide synthase] thioesterase
Reference
1  [PMID:23653178]
  Authors
Xu W, Chooi YH, Choi JW, Li S, Vederas JC, Da Silva NA, Tang Y
  Title
LovG: the thioesterase required for dihydromonacolin L release and lovastatin nonaketide synthase turnover in lovastatin biosynthesis.
  Journal
Angew Chem Int Ed Engl 52:6472-5 (2013)
DOI:10.1002/anie.201302406
  Sequence
[ag:EAU29411]
Other DBs
ExplorEnz - The Enzyme Database: 3.1.2.31
IUBMB Enzyme Nomenclature: 3.1.2.31
ExPASy - ENZYME nomenclature database: 3.1.2.31
BRENDA, the Enzyme Database: 3.1.2.31

  All links  
Pathway (7)   
   KEGG PATHWAY (6)   
   KEGG MODULE (1)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (3)   
   KEGG REACTION (1)   
   KEGG RCLASS (2)   
Gene (2)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
Protein sequence (6)   
   UniProt (3)   
   SWISS-PROT (3)   
Protein domain (3)   
   InterPro (3)   
All databases (25)   

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