KEGG ENZYME: 3.1.2.32

ENZYME: 3.1.2.32

Entry

EC 3.1.2.32                 Enzyme

Name

2-aminobenzoylacetyl-CoA thioesterase;
pqsE (gene name)

Class

Hydrolases;
Acting on ester bonds;
Thioester hydrolases

Sysname

(2-aminobenzoyl)acetyl-CoA hydrolase

Reaction(IUBMB)

(2-aminobenzoyl)acetyl-CoA + H2O = (2-aminobenzoyl)acetate + CoA [RN:R11542]

Reaction(KEGG)

R11542

Substrate

(2-aminobenzoyl)acetyl-CoA [CPD:C21452];
H2O [CPD:C00001]

Product

(2-aminobenzoyl)acetate [CPD:C21453];
CoA [CPD:C00010]

Comment

The enzyme, characterized from the bacterium Pseudomonas aeruginosa, participates in the production of the signal molecule 2-heptyl-4(1H)-quinolone (HHQ).

History

EC 3.1.2.32 created 2016

Pathway

ec00405

Phenazine biosynthesis

ec01110

Biosynthesis of secondary metabolites

Orthology

K20257

2-aminobenzoylacetyl-CoA thioesterase

Genes

PAE:	PA1000(pqsE)

PAEV:

N297_1033

PAEI:

N296_1033

PAU:	PA14_51380(pqsE)

PAP:	PSPA7_4398

PAG:	PLES_43251(pqsE)

PAF:	PAM18_4048(pqsE)

PNC:	NCGM2_1854(pqsE)

PAEB:

NCGM1900_1668(pqsE)

PDK:	PADK2_20740

PSG:	G655_20300

PRP:	M062_05450

PAEP:

PA1S_20970

PAER:

PA1R_gp4597

PAEM:

U769_20815

PAEL:

T223_22095

PAES:

SCV20265_4442

PAEU:

BN889_01052(pqsE)

PAEG:

AI22_12970

PAEC:

M802_1030

PAEO:

M801_1033

PPAA:

B7D75_20125

BPS:

BPSS0485

BPM:	BURPS1710b_A2038

BPL:	BURPS1106A_A0657

BPD:	BURPS668_A0749

BPSE:

BDL_3711

BPSM:

BBQ_5711

BPSU:

BBN_3885

BPSD:

BBX_5548

BPZ:	BP1026B_II0539

BPQ:	BPC006_II0703

BPK:

BBK_5690

BPSH:

DR55_4867

BPSA:

BBU_5562

BPSO:

X996_4617

BUT:

X994_4135

BTE:	BTH_II1931

BTQ:

BTQ_5214

BTJ:

BTJ_3845

BTZ:

BTL_4699

BTD:

BTI_4293

BTV:

BTHA_5528

BTHE:

BTN_4338

BTHM:

BTRA_4604

BTHA:

DR62_4387

BTHL:

BG87_4671

BOK:

DM82_4588

BOC:

BG90_6004

BUU:	WS70_19845

BSAV:

WS86_21100

BHG:	I6G56_31560

BUD:	AQ610_21735

BAM:

Bamb_5767

BAC:	BamMC406_5527

BCEP:

APZ15_37365

BPYR:

ABD05_31295

BCON:

NL30_31565

BUB:

BW23_4061

BSTG:

WT74_17005

BUL:

BW21_3834

SECH:

B18_16630

GME:

Gmet_2200

DOL:

Dole_1494

DAL:	Dalk_0799 Dalk_3752

DOV:	DSCO28_47760

DWD:	DSCW_14780

DALK:

DSCA_14130 DSCA_25720

DML:	Dmul_20230

DMM:	dnm_046970

DTI:	Desti_1708

DBR:

Deba_1389

DMP:

FAK_00250

CKL:

CKL_0030

CKR:

CKR_0021

CAPR:

EQM14_09425

SWO:	Swol_1292 Swol_1480

SLP:	Slip_0679 Slip_1105

DDL:	Desdi_0644

DMT:	DESME_05105

DGI:	Desgi_1436 Desgi_3231

ALKA:

J0B03_08435

BPRS:

CK3_16350

CMIU:

B1H56_12515

PUF:

UFO1_3636

PFT:

JBW_00392

STED:

SPTER_30530(gloB_2)

OLS:

Olsu_1018

CCU:	Ccur_01300

ARH:	AHiyo8_45130

CAP:	CLDAP_39220

COY:	HF329_06220

CHZ:

CHSO_1946

TTK:

TST_1179

GAC:

GACE_1202

GAH:

GAH_01404

» show all

Reference

1 [PMID:19788310]

Authors

Yu S, Jensen V, Seeliger J, Feldmann I, Weber S, Schleicher E, Haussler S, Blankenfeldt W

Title

Structure elucidation and preliminary assessment of hydrolase activity of PqsE, the Pseudomonas quinolone signal (PQS) response protein.

Journal

Biochemistry 48:10298-307 (2009)
DOI:10.1021/bi900123j

Sequence

[pae:PA1000]

Reference

2 [PMID:25960261]

Authors

Drees SL, Fetzner S

Title

PqsE of Pseudomonas aeruginosa Acts as Pathway-Specific Thioesterase in the Biosynthesis of Alkylquinolone Signaling Molecules.

Journal

Chem Biol 22:611-8 (2015)
DOI:10.1016/j.chembiol.2015.04.012

Sequence

[pae:PA1000]

Other DBs

ExplorEnz - The Enzyme Database:

3.1.2.32

IUBMB Enzyme Nomenclature:

3.1.2.32

ExPASy - ENZYME nomenclature database:

3.1.2.32

BRENDA, the Enzyme Database:

3.1.2.32

DBGET integrated database retrieval system