| Entry |
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| Name |
deoxyribonuclease I;
pancreatic DNase;
DNase;
thymonuclease, dornase;
dornava;
dornavac;
pancreatic deoxyribonuclease;
pancreatic dornase;
deoxyribonuclease (pancreatic);
pancreatic DNase;
DNAase;
deoxyribonucleic phosphatase;
DNase I;
alkaline deoxyribonuclease;
alkaline DNase;
endodeoxyribonuclease I;
DNA depolymerase;
Escherichia coli endonuclease I;
deoxyribonuclease A;
DNA endonuclease;
DNA nuclease
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| Class |
Hydrolases;
Acting on ester bonds;
Endodeoxyribonucleases producing 5'-phosphomonoesters
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| Reaction(IUBMB) |
Endonucleolytic cleavage to 5'-phosphodinucleotide and 5'-phosphooligonucleotide end-products
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| Comment |
Preference for double-stranded DNA.
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| History |
EC 3.1.21.1 created 1961 as EC 3.1.4.5, transferred 1978 to EC 3.1.21.1, modified 1981
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| Orthology |
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| Genes |
| ACHL: | 103807409(DNASE1L2) |
| PCRI: | 104023951(DNASE1L2) |
| ACS: | 100560207(dnase1) 100562917 |
| SANH: | 107676287 107685934 107690335 |
| CCAR: | 109058271 109079779 |
| CAUA: | 113041462 113046984 |
| CGIB: | 127948762 127952055 |
| CHAR: | 105899892 105899997 |
| TBEN: | 117479089(dnase1) 117479098 117479099 117479101 117479102 |
| PGEO: | 117441045 117442354 117442356 117442360 |
| GACU: | 117554384 117554386 117554388 117554389 |
| EMAC: | 134877452 134877453 134878079(dnase1) |
| PPUG: | 119220213 119220214 |
| PSWI: | 130189377 130189378 |
| MZE: | 101472954 101477007 101485654 112429679 112431505 112431506 112431507 112431513 |
| ONL: | 100700560 100700928 102076094 109202009 |
| PRET: | 103468312(dnase1l2) |
| CVG: | 107099649(dnase1l2) 107103768(dnase1) |
| CTUL: | 119772698 119772714(dnase1) |
| GMU: | 124863076 124864667(dnase1) |
| ALIM: | 106526804(dnase1l2) |
| CSEM: | 103393635(dnase1l2) |
| LCF: | 108889278 108889279 108898604 |
| BPEC: | 110171440(dnase1l2) |
| MALB: | 109967577(dnase1l2) |
| STRU: | 115171982 115208375 |
| OMY: | 110487138(dnase1) 110515889 |
| OGO: | 124020921 124022736 124022827 124029970 |
| PSPA: | 121294185(dnase1) 121301220 |
| BFO: | 118408747 118411538 118411692 118412585 118421836 118427705 |
| BBEL: | 109463851 109465490 109478323 |
| LPIC: | 129255357 129256304 |
| AJC: | 117105309 117108016 117118217 |
| PCHN: | 125025043 125048196 |
| PPOI: | 119100688 119101325 |
| LGI: | LOTGIDRAFT_105537 LOTGIDRAFT_121655 LOTGIDRAFT_168246 |
| PVUL: | 126820937 126827641 |
| PCAN: | 112566954 112571981 |
| CVN: | 111109917 111109972 111125844 111125855 111125865 111125873 |
| MMER: | 123532629 123562872 |
| RPHI: | 132721199 132748733 132752110 |
| DPOL: | 127855864 127866072 127873105 |
| LAK: | 106168371 106172672 106179924 |
| AMIL: | 114966736 114972136 |
| SPIS: | 111332263 111334753 |
| HSY: | 130639588 130642558 130655400 130655433 |
| TAD: | TRIADDRAFT_25440 TRIADDRAFT_37773 |
| ECOO: | ECRM13514_3829(endA) |
| ECOH: | ECRM13516_3674(endA) |
| ECW: | EcE24377A_3288(endA) |
| EDJ: | ECDH1ME8569_2845(endA) |
| ECOI: | ECOPMV1_03218(endA) |
| REE: | electrica_00749(endA) |
| RTG: | NCTC13098_01014(endA_1) |
| CLAP: | NCTC11466_00594(endA) |
| KIE: | NCTC12125_04696(endA_1) |
| CMIK: | PMARG_ME00212(nucM) |
| AHN: | NCTC12129_04138(endA) |
| PSHI: | SAMEA2665130_2500(endA) |
| YPG: | YpAngola_A3345(endA) |
| YPI: | YpsIP31758_0839(endA) |
| SMW: | SMWW4_v1c41270(endA) |
| SFJ: | SAMEA4384070_4141(endA) |
| SOF: | NCTC11214_02590(endA) |
| PAQU: | DMB82_0017725(endA) |
| DIC: | Dpoa569_000502(endA) |
| PMR: | PMI1441(endA) PMI2452 |
| PCIB: | F9282_10425 F9282_16210 |
| PTHA: | OI982_03495 OI982_15925 |
| PHEI: | NCTC12003_02239(endA) |
| PRJ: | NCTC6933_01729(endA) |
| LRI: | NCTC12151_02267(endA) |
| VCF: | IR04_07365 IR04_08550 |
| VCE: | Vch1786_I0128 Vch1786_I2791(dns) |
| VCQ: | EN18_06540 EN18_19385 |
| VPH: | VPUCM_0751 VPUCM_2691 |
| VAF: | D1115_02535 D1115_17055 |
| VPL: | SA104470976_02230(dns) |
| PPR: | PBPRA3136(ENDA) PBPRC0029 |
| PGH: | FH974_02315(endA) FH974_26075 |
| PAEB: | NCGM1900_3677(endA) |
| PRE: | PCA10_04830 PCA10_19680(endA) PCA10_p0700(endA) |
| PPSE: | BN5_3012(endA1) BN5_3899(endA3) |
| PNT: | G5B91_17400 G5B91_32785 |
| PPU: | PP_2451(endX) PP_3375(endA) |
| PPG: | PputGB1_2569 PputGB1_3521 |
| PPB: | PPUBIRD1_2405(endA) PPUBIRD1_3230 |
| PPX: | T1E_3439(endX) T1E_5147(endA) |
| PPUT: | L483_13875 L483_21260 |
| PPUN: | PP4_18760(endA) PP4_27650(endA) |
| PFV: | Psefu_1050 Psefu_2188 |
| POR: | APT59_11775 APT59_13195 |
| PALD: | LU682_013140 LU682_018695 |
| PCOF: | POR16_10230 POR16_14185 |
| PPRC: | PFLCHA0_c21430(endX) |
| PMUD: | NCTC8068_03430(endA) |
| PFW: | PF1751_v1c36700(endA) |
| PLUL: | FOB45_00295 FOB45_00870 FOB45_02480 FOB45_13410 |
| PPUU: | PputUW4_02640(endA1) PputUW4_03406(endA2) |
| PALK: | PSAKL28_19360 PSAKL28_25860 |
| PRH: | LT40_07260 LT40_10230 |
| PSES: | PSCI_3931 PSCI_4526(endA1) |
| PSIL: | PMA3_09270 PMA3_14425 |
| PALL: | UYA_06435 UYA_21715 |
| PUM: | HGP31_11090 HGP31_15040 |
| POJ: | PtoMrB4_05550(endA_1) PtoMrB4_20280(endA_2) |
| PLAL: | FXN65_02325 FXN65_18845 |
| PSEJ: | HNQ25_04310 HNQ25_17780 |
| PKH: | JLK41_07010 JLK41_22260 |
| PTY: | JWV26_07385 JWV26_17340 |
| PAZE: | KSS91_09875 KSS91_14435 KSS91_14830 |
| PORY: | EJA05_11700 EJA05_18015 |
| PTW: | TUM18999_06910(endA_1) TUM18999_38100(endA_2) |
| PTAE: | NCTC10697_02840(endA) |
| PCAV: | D3880_02215 D3880_06205 |
| PHF: | NLY38_18405 NLY38_22565 |
| PSIH: | LOY51_11525 LOY51_17390 |
| PKM: | PZ739_14620 PZ739_17900 |
| PSOA: | PSm6_25890(endA_1) PSm6_43580(endA_2) |
| PTAI: | ICN73_16345 ICN73_19035 |
| PKK: | QQ992_12435 QQ992_17750 |
| PCHE: | QYM18_04925 QYM18_14445 |
| PSJY: | AA098_11055 AA098_15190 |
| PSTU: | UIB01_05945 UIB01_09755 |
| PSED: | DM292_03530 DM292_07270 |
| PCHL: | LLJ08_05480 LLJ08_09070 |
| AVN: | Avin_02310 Avin_40130 |
| AVL: | AvCA_02310 AvCA_40130 |
| AVD: | AvCA6_02310 AvCA6_40130 |
| ACX: | Achr_10280 Achr_20230 Achr_2250 Achr_f1730 Achr_f2490 |
| PBAU: | OS670_19630 OS670_20665 OS670_20830 |
| SBM: | Shew185_0810 Shew185_4415 |
| SBN: | Sbal195_0842 Sbal195_4577 Sbal195_4599 |
| SBT: | Sbal678_0867 Sbal678_4612 |
| SHW: | Sputw3181_0783 Sputw3181_1149 |
| SPSW: | Sps_02898 Sps_02982 |
| SPOL: | FH971_02610 FH971_14010 |
| SAES: | HBH39_02980 HBH39_18985 |
| SCAA: | TUM17387_07470(endA) |
| SPSH: | FM037_03080 FM037_03890 FM037_24385 |
| SEUR: | FM038_003385 FM038_003520 |
| SHEJ: | MZ182_15100 MZ182_16870(endA) |
| COLA: | DBO93_07755 DBO93_11865 DBO93_12260 |
| PTN: | PTRA_a1920(endA) PTRA_a3433(endA) |
| PSEO: | OM33_00610 OM33_01295 |
| PEA: | PESP_a0162 PESP_a3691(endA) |
| PNG: | PNIG_a3658(endA) PNIG_p0050(endA) |
| PCAR: | PC2016_0147 PC2016_3947 |
| MMAA: | FR932_00065 FR932_00680 |
| LIB: | E4T55_03435 E4T55_08010 |
| LJR: | NCTC11533_01216(dns) |
| LCJ: | NCTC11976_02123(dns) |
| LWA: | SAMEA4504053_3059(dns) |
| APAC: | S7S_07025 S7S_15175 |
| AEL: | NCTC12917_01187(dns) |
| BTHG: | MS2017_1320 MS2017_1387 |
| PSE: | NH8B_1691 NH8B_2122 NH8B_2832 |
| PLG: | NCTC10937_02104(dns) NCTC10937_03151(endA1) |
| MGM: | Mmc1_1309 Mmc1_2065 Mmc1_2835 |
| APOC: | APORC_1237 APORC_1433 |
| ALP: | LPB137_05140 LPB137_05175 |
| BBAT: | Bdt_0882(endA) Bdt_3416 |
| BBW: | BDW_04280 BDW_09645 BDW_10330 BDW_13145 |
| BBAC: | EP01_02695 EP01_14790 |
| BMX: | BMS_0683 BMS_1325 BMS_2373 |
| HAX: | BALOs_1130 BALOs_1845 BALOs_1857 BALOs_2510 |
| BSTO: | C0V70_11510 C0V70_13360 C0V70_13365 |
| BFD: | NCTC4823_01447(bsn_1) NCTC4823_01634(bsn_2) NCTC4823_03030(bsn_3) |
| BLEN: | NCTC4824_01251(bsn) |
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| Reference |
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| Authors |
PRIVAT DE GARILHE M, LASKOWSKI M |
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| Title |
Study of the enzymatic degradation of deoxyribonucleic acid by two different deoxyribonucleopolymerases. |
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| Journal |
J Biol Chem 215:269-76 (1955) |
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| Reference |
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| Authors |
Kunitz M |
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| Title |
Isolation of Crystalline Desoxyribonuclease From Beef Pancreas. |
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| Journal |
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| Reference |
3 |
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| Authors |
Laskowski, M. |
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| Title |
, Sr. Venom exonuclease. |
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| Journal |
In: Boyer, P.D. (Ed.), The Enzymes, 3rd ed., vol. 4, Academic Press, New York, 1971, p. 313-328. |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 3.1.21.1 |
| ExPASy - ENZYME nomenclature database: | 3.1.21.1 |
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