KEGG ENZYME: 3.1.3.101

ENZYME: 3.1.3.101

Entry

EC 3.1.3.101                Enzyme

Name

validoxylamine A 7'-phosphate phosphatase;
vldH (gene name)

Class

Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases

Sysname

validoxylamine-A 7'-phosphate phosphohydrolase

Reaction(IUBMB)

validoxylamine A 7'-phosphate + H2O = validoxylamine A + phosphate [RN:R11240]

Reaction(KEGG)

R11240

Substrate

validoxylamine A 7'-phosphate [CPD:C21219];
H2O [CPD:C00001]

Product

validoxylamine A [CPD:C17700];
phosphate [CPD:C00009]

Comment

The enzyme, characterized from the bacterium Streptomyces hygroscopicus subsp. limoneus, is involved in the biosynthesis of the antifungal agent validamycin A.

History

EC 3.1.3.101 created 2016

Pathway

ec00525

Acarbose and validamycin biosynthesis

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K20437

validoxylamine A 7'-phosphate phosphatase

Genes

SHY:

SHJG_0271

SHO:	SHJGH_0105

SNQ:	CP978_00045

SCYG:

S1361_37275

SPEU:

CGZ69_02110

SHK:	J2N69_30930

SDD:	D9753_08360

SCIR:

STRCI_006247

GYU:	FE374_05670

NOQ:	LN652_08445

THAO:

NI17_015255

TALX:

FOF52_12720

AGRA:

AGRA3207_002910

AMAZ:

LUW76_17900

ACIR:

OG979_24265

MHAI:

OHB01_17735

VCB:	CYK25_005465

» show all

Reference

1 [PMID:21766819]

Authors

Asamizu S, Yang J, Almabruk KH, Mahmud T

Title

Pseudoglycosyltransferase catalyzes nonglycosidic C-N coupling in validamycin a biosynthesis.

Journal

J Am Chem Soc 133:12124-35 (2011)
DOI:10.1021/ja203574u

Other DBs

ExplorEnz - The Enzyme Database:

3.1.3.101

IUBMB Enzyme Nomenclature:

3.1.3.101

ExPASy - ENZYME nomenclature database:

3.1.3.101

BRENDA, the Enzyme Database:

3.1.3.101

DBGET integrated database retrieval system