KEGG ENZYME: 3.1.3.103

ENZYME: 3.1.3.103

Entry

EC 3.1.3.103                Enzyme

Name

3-deoxy-D-glycero-D-galacto-nonulopyranosonate 9-phosphatase;
3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate-9-phosphate phosphatase

Class

Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases

Sysname

3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate 9-phosphohydrolase

Reaction(IUBMB)

3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate 9-phosphate + H2O = 3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate + phosphate [RN:R11440]

Reaction(KEGG)

R11440

Substrate

3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate 9-phosphate [CPD:C21383];
H2O [CPD:C00001]

Product

3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate [CPD:C20934];
phosphate [CPD:C00009]

Comment

The enzyme, characterized from the bacterium Bacteroides thetaiotaomicron, is part of the biosynthesis pathway of the sialic acid 3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate (Kdn). Kdn is abundant in extracellular glycoconjugates of lower vertebrates such as fish and amphibians, but is also found in the capsular polysaccharides of bacteria that belong to the Bacteroides genus.

History

EC 3.1.3.103 created 2016

Pathway

ec00520

Amino sugar and nucleotide sugar metabolism

ec01100

Metabolic pathways

Orthology

K21055

3-deoxy-D-glycero-D-galacto-nononate 9-phosphatase

Genes

HSH:	NHP194022_04600

HAIL:

ASB7_00190

SDIA:

QU667_10080

BPAA:

K7I13_00560

SBU:	SpiBuddy_2424

BTH:

BT_1713

BTHO:

Btheta7330_01303 Btheta7330_02993

BCEL:

BcellWH2_03094

BIS:	DXK01_006205

BEG:	INE88_01922

BSTE:

K6V31_10245

DDB:	E7747_08105

BVS:	BARVI_00425

ANF:

AQPE_2134

SHT:	KO02_22670

CAMU:

CA2015_3636

CLIT:

OQ292_15535

RSR:	T7867_13005

FAX:	FUAX_28070

FAZ:	M0M57_00270

ASL:	Aeqsu_2922

AIC:	JK629_04870

SMIS:

LDL76_16000

MGEL:

G5B37_10200

SINH:

LS482_08945

FBE:	FF125_10320

LUY:	QZH61_06935

HWS:	RNZ46_07200

PTAN:

CRYO30217_01042

» show all

Reference

1 [PMID:18804026]

Authors

Wang L, Lu Z, Allen KN, Mariano PS, Dunaway-Mariano D

Title

Human symbiont Bacteroides thetaiotaomicron synthesizes 2-keto-3-deoxy-D-glycero-D- galacto-nononic acid (KDN).

Journal

Chem Biol 15:893-7 (2008)
DOI:10.1016/j.chembiol.2008.08.005

Sequence

[bth:BT_1713]

Reference

2 [PMID:18986982]

Authors

Lu Z, Wang L, Dunaway-Mariano D, Allen KN

Title

Structure-function analysis of 2-keto-3-deoxy-D-glycero-D-galactonononate-9-phosphate phosphatase defines specificity elements in type C0 haloalkanoate dehalogenase family members.

Journal

J Biol Chem 284:1224-33 (2009)
DOI:10.1074/jbc.M807056200

Sequence

[bth:BT_1713]

Other DBs

ExplorEnz - The Enzyme Database:

3.1.3.103

IUBMB Enzyme Nomenclature:

3.1.3.103

ExPASy - ENZYME nomenclature database:

3.1.3.103

BRENDA, the Enzyme Database:

3.1.3.103

DBGET integrated database retrieval system