KEGG   ENZYME: 3.1.3.108
Entry
EC 3.1.3.108                Enzyme                                 
Name
nocturnin;
NOCT (gene name);
nocturnin (curled);
MJ0109 (gene name);
NADP phosphatase;
NADPase
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
Sysname
NADPH 2'-phosphohydrolase
Reaction(IUBMB)
(1) NADPH + H2O = NADH + phosphate [RN:R12587];
(2) NADP+ + H2O = NAD+ + phosphate [RN:R00118]
Reaction(KEGG)
R00118 R12587
Substrate
NADPH [CPD:C00005];
H2O [CPD:C00001];
NADP+ [CPD:C00006]
Product
NADH [CPD:C00004];
phosphate [CPD:C00009];
NAD+ [CPD:C00003]
Comment
The mammalian mitochondrial enzyme is a rhythmically expressed protein that regulates metabolism under the control of circadian clock. It has a slight preference for NADPH over NADP+. The archaeal enzyme, identified in Methanocaldococcus jannaschii, is bifunctional acting as NAD+ kinase (EC 2.7.1.23) and NADP+ phosphatase with a slight preference for NADP+ over NADPH.
History
EC 3.1.3.108 created 2020
Orthology
K18764  nocturnin
Genes
HSA25819(NOCT)
PTR100611804(NOCT)
PPS100979611(NOCT)
GGO101133256(NOCT)
PON100449251(NOCT)
NLE100591529(NOCT)
HMH116464020(NOCT)
MCC100428993(NOCT)
MCF102134207(NOCT)
MTHB126954609
MNI105493258(NOCT)
CSAB103236274(NOCT)
CATY105580807(CCRN4L)
PANU100997677(NOCT)
TGE112624769(NOCT)
MLEU105543649(CCRN4L)
RRO104654345(NOCT)
RBB108536941(NOCT)
TFN117085922(NOCT)
PTEH111551937(NOCT)
CANG105513704(CCRN4L)
CJC100393251(NOCT)
SBQ101030297(CCRN4L)
CIMI108285596(NOCT)
CSYR103255271(NOCT)
MMUR105872360(NOCT)
LCAT123638565(NOCT)
PCOQ105818763(CCRN4L)
OGA100962419(NOCT)
MMU12457(Noct)
MCAL110291122(Noct)
MPAH110320210(Noct)
RNO310395(Noct)
MCOC116094444(Noct)
ANU117707840(Noct)
MUN110545133(Noct)
CGE100766002(Noct)
MAUA101830083(Noct)
PROB127216289(Noct)
PLEU114695851(Noct) 114707977
MORG121452881(Noct)
MFOT126499231
AAMP119825973(Noct)
NGI103742363(Noct)
HGL101710110(Noct)
CPOC100713041(Noct)
CCAN109691470(Noct)
DORD105995684(Noct)
DSP122127151(Noct)
PLOP125341701(Noct)
NCAR124994353
MMMA107136589(Noct)
OCU100348337
OPI101518231(NOCT)
TUP102502756(NOCT)
GVR103600636(CCRN4L)
CFA483818(NOCT)
CLUD112669290(NOCT)
VVP112934917(NOCT)
VLG121493119(NOCT)
NPO129504355(NOCT)
AML100472917(NOCT)
UMR103657961(NOCT)
UAH113255683(NOCT)
UAR123793276(NOCT)
ELK111149080
LLV125093397
MPUF101692678(NOCT)
MNP132003129(NOCT)
MLK131827682(NOCT)
NVS122919185(NOCT)
ORO101365311(CCRN4L)
EJU114208164(NOCT)
ZCA113924598(NOCT)
MLX118022315(NOCT)
NSU110571230(NOCT)
LWW102737589(NOCT)
FCA101092681(NOCT)
PYU121029610(NOCT)
PCOO112858609(NOCT)
PBG122497251(NOCT)
LRUF124520050
PTG102965630(NOCT)
PPAD109249387(NOCT)
PUC125923702
AJU106976192
HHV120243132(NOCT)
BTA540641(NOCT)
BOM102279918(NOCT)
BIU109571342(NOCT)
BBUB102399873(NOCT)
BBIS104981272(CCRN4L)
CHX102187886(NOCT)
OAS101117790(NOCT)
BTAX128062375(NOCT) 128071342
ODA120870925(NOCT)
CCAD122452524(NOCT)
MBEZ129542657(NOCT)
SSC100513746(NOCT)
CFR102524312(NOCT)
CBAI105068704(CCRN4L)
CDK105087080(NOCT)
VPC102538495
BACU103003260(NOCT)
LVE103072303(CCRN4L)
OOR101283045(NOCT)
DLE111164860(NOCT)
PCAD102992628(NOCT)
PSIU116753825(NOCT)
NASI112399817(NOCT)
ECB100071468(NOCT)
EPZ103549003(NOCT)
EAI106837991(NOCT)
MYB102260842(NOCT)
MYD102759031(NOCT)
MMYO118651580 118658853(NOCT)
MLF102428003(NOCT)
MNA107534921(NOCT)
PKL118711607(NOCT)
EFUS103290399(NOCT)
HAI109394194(NOCT)
DRO112312425(NOCT)
SHON118995459(NOCT)
AJM119034879(NOCT)
PDIC114504158(NOCT)
PHAS123813997(NOCT)
MMF118615874(NOCT)
RFQ117038246(NOCT)
PPAM129062301(NOCT)
PALE102883027(NOCT)
PGIG120613209(NOCT)
PVP105301556(NOCT)
RAY107515347(NOCT)
MJV108407063(NOCT)
TOD119234772(NOCT)
SARA101549546(CCRN4L)
LAV100677271(NOCT)
TMU101347454
ETF101647778(NOCT)
DNM101427251(NOCT)
MDO100027658(NOCT)
GAS123251016(NOCT)
SHR100930989(NOCT)
AFZ127540638
PCW110194902(NOCT)
OAA100078856(NOCT)
GGA404779(NOCT)
PCOC116226093(NOCT)
MGP100541508(NOCT)
CJO107313121(NOCT)
TPAI128084196(NOCT)
LMUT125692468(NOCT)
NMEL110399084(NOCT)
APLA101797379(NOCT)
ACYG106040962(NOCT)
CATA118250885(NOCT)
AFUL116488596(NOCT)
TGU100231561(NOCT)
LSR110480519(NOCT)
SCAN103822546(NOCT)
PMOA120496055(NOCT)
OTC121339918(NOCT)
PRUF121354684(NOCT)
GFR102040001(NOCT)
FAB101806807(NOCT)
OMA130252568(NOCT)
PHI102100975(NOCT)
PMAJ107198931(NOCT)
CCAE111928919(NOCT)
CCW104697280(NOCT)
CBRC103614517(NOCT)
ETL114058376(NOCT)
ZAB102063908(NOCT)
ACHL103804840(CCRN4L)
SVG106864038(NOCT)
MMEA130582142(NOCT)
HRT120753022(NOCT)
FPG101917647(NOCT)
FCH102053174(NOCT)
CLV102088785(NOCT)
EGZ104135809(CCRN4L)
NNI104015978(CCRN4L)
PCRI104032285(CCRN4L)
PLET104615944(CCRN4L)
EHS104509053(CCRN4L)
PCAO104043146(CCRN4L)
ACUN113479829(NOCT)
TALA104369517(NOCT)
PADL103920979(CCRN4L)
AFOR103908037(NOCT)
ACHC115338678(NOCT)
HALD104312627(CCRN4L)
HLE104841761(CCRN4L)
AGEN126044800
GCL127015925
CCRI104161150(CCRN4L)
CSTI104563375(CCRN4L)
CMAC104483879(CCRN4L)
MUI104540965(CCRN4L)
BREG104640636(CCRN4L)
FGA104071983(CCRN4L)
GSTE104263383(CCRN4L)
LDI104349266(CCRN4L)
MNB103780478(CCRN4L)
OHA104336715(CCRN4L)
NNT104409418(CCRN4L)
SHAB115610637(NOCT)
DPUB104296870(CCRN4L)
PGUU104463899(CCRN4L)
ACAR104530792(NOCT)
CPEA104398832(CCRN4L)
AVIT104279765(CCRN4L)
CVF104292758(CCRN4L)
RTD128909748(NOCT)
CUCA104066442(CCRN4L)
TEO104377144(CCRN4L)
BRHI104493236(CCRN4L)
AAM106491891(NOCT)
AROW112965417(NOCT)
NPD112950172(NOCT)
TGT104577902(CCRN4L)
DNE112986740(NOCT)
SCAM104153488(CCRN4L)
ASN102373172(NOCT)
AMJ102567362(NOCT)
CPOO109309613(NOCT)
GGN109301160(NOCT)
PSS102451508(NOCT)
CMY102939146(NOCT)
DCC119854597(NOCT)
CPIC101936301(NOCT)
TST117878109(NOCT)
CABI116838879(NOCT)
MRV120406199(NOCT)
ACS100556517(noct)
ASAO132776850(NOCT)
PVT110073655(NOCT)
SUND121930735(NOCT)
PBI103058940(NOCT)
PMUR107293158(NOCT)
CTIG120308385(NOCT)
TSR106545270(NOCT)
PGUT117680128(NOCT)
APRI131202970(NOCT)
PTEX113434721(NOCT)
NSS113412908(NOCT)
VKO123023763(NOCT)
PMUA114604123(NOCT)
PRAF128421086(NOCT)
ZVI118083410(NOCT)
HCG128328518(NOCT)
GJA107110787(NOCT)
STOW125440398(NOCT)
EMC129336741(NOCT)
XLA378568(noct.L) 734309(noct.S)
XTR549285(noct)
NPR108787519(NOCT)
RTEM120919058(NOCT)
BBUF120989975(NOCT)
BGAR122943301(NOCT)
MUO115461700(NOCT)
GSH117357962(NOCT)
DRE568973(noctb) 572044(nocta)
SRX107714224 107742507 107756481(noct)
SANH107676528 107680657 107692596 107702303
SGH107550850(noct) 107562977 107563986 107601501
CCAR109045774 109079183 109102500
CAUA113044314 113091093 113114064
CGIB127948694 127970881 128027532
PTET122352499(noctb) 122357557(nocta)
LROH127166104(noctb) 127176027(nocta)
OMC131549294(noctb) 131553811(nocta)
PPRM120460783(nocta) 120481331(noctb)
RKG130071398(noctb) 130089758(nocta)
MAMB125258890(nocta) 125272488(noctb)
CIDE127509561 127525632
MASI127412676 127417760 127443400 127445407
TROS130553649(noctb) 130563809(nocta)
TDW130412926(noctb) 130437825(nocta)
MANU129422882(nocta) 129444845(noctb)
IPU108268604(nocta)
IFU128611948(nocta)
PHYP113542743(noct)
SMEO124385831(nocta)
TFD113645990(nocta)
TVC132855531(nocta)
AMEX103024657(noct)
CMAO118806990(nocta)
EEE113581505(noct)
CHAR105906267(nocta) 105908471(noctb)
TRU101067716 101074895
TFS130527329 130531180(nocta)
TNGGSTEN00023219G001 GSTEN00026635G001
LCO104922934(noct) 104938899
NCC104959560 104966628
TBEN117482054 117485366(nocta)
CGOB115013792 115015035(noct)
PGEO117447582 117454208(nocta)
GACU117560284 117561811(nocta)
ELY117255743 117261177(nocta)
EFO125886576 125894363(nocta)
PLEP121941963(noctb) 121947728(nocta)
SLUC116039580 116042198(nocta)
ECRA117951223(nocta) 117955006(noctb)
ESP116669841(noct) 116695867
PFLV114562853(noct) 114565677
GAT120817933(nocta) 120825114
PPUG119211376(nocta) 119217668
AFB129095468(noctb) 129117103(nocta)
CLUM117735243 117737444(nocta)
MSAM119884055 119888743(nocta) 119899704
SCHU122873910 122879935(nocta)
CUD121508649 121516664(nocta)
ALAT119008016(nocta) 119027483
MZE101478528(noct)
ONL100690381(noct)
OAU116331504(noctb)
OLA101157593(noct)
OML112153354 112157020
XMA102226828 102237197
XCO114145157 114153060(noct)
XHE116714362 116719974
PRET103463886 103471162(noct)
PFOR103132691 103154723(noct)
PLAI106946193 106963244(noct)
PMEI106905149 106931160
GAF122836546(nocta)
PPRL129353840(nocta) 129367065(noctb)
CVG107093243 107097348
CTUL119773479(nocta) 119786952
GMU124859873(nocta) 124868318
NFU107389498(noct) 107396430
KMR108245508 108249656(nocta)
ALIM106511359 106511585 106524622(noct)
NWH119409150(nocta) 119422687
AOCE111572374(noct) 111585149
MCEP125004132 125008415(nocta)
CSEM103384260(noct)
POV109624667 109627218
SSEN122762066(noctb) 122778975
HHIP117765493 117769693(nocta)
HSP118098124 118112237(nocta)
LCF108895516(nocta) 108900154
SDU111229271 111230402(noct)
SLAL111663590(noct) 111666744
XGL120784882(nocta) 120800067
HCQ109514429(noct) 109527505
SSCV125968450
SBIA133506132(noctb)
PEE133404024(noctb) 133408029(nocta)
PTAO133476513(noctb) 133484482
BPEC110155793 110175173(noct)
MALB109957867 109966424(noct)
BSPL114862797 114864915(nocta)
SJO128362586(nocta) 128370701
SASA106596388 106597766 106604687 106610553
STRU115172215 115182600 115182606
OTW112220937(nocta) 112244497 112255690
OMY110488807(nocta) 110497191 110497192
OGO123993401(nocta) 124023194 124023344
ONE115126566 115130688
OKI109864774(noct) 109887460 116352827
OKE118377976(nocta) 127925236
SALP111965719 111967170 112078726
SNH120041083 120048106(nocta)
CCLU121536531 121542552
ELS105020852 105029048
SFM108925729 108930757
PKI111853054
AANG118228032 118231012
LOC102682701(noct)
PSPA121325246 121330605
ARUT117408755 117420930
PSEX120527823(nocta)
LCM102349012(NOCT)
CMK103181305
RTP109932243(noct)
CPLA122539350(nocta)
HOC132833315
LERI129701956(nocta)
PMRN116944946(NOCT)
LRJ133341818(NOCT)
BFO118420286
BBEL109467894
SCLV120329053
SPU591893
APLC110988644
AJC117112949
SKO100368766
DMEDmel_CG31299(cu)
DER26527069
DSE116801625
DSIDsimw501_GD26876(Dsim_GD26876)
DYADyak_GE27400
DAN6499531
DSR110188135
DPO4803139
DPE113567256
DMN108156775
DWI26528816
DGR116805427
DMODmoj_GI25727
DAZ108621833
DNV108659911
DHE111600242
CCAT101460917
RZE108373523
TDA119668788 119672624
MDE101887281
LCQ111674873
GFS119631833
ECOE129946143
CLON129610210
HIS119647579
ACOZ120959966
AARA120904983
AMER121595200
ASTE118509089
AFUN125760850
AMOU128301157
AALI118460707
AAG5570471
AALB109398703 109404878
CQUCpipJ_CPIJ011434
CPII120420797
CNS116351978
BCOO119073735
DSM124404757
NPT124211984
NFB124176761
NLO107222528
NVG124298306
AROA105692539
TCA663596
DPA109539469
AGRG126739490
ATD109598810
AGB108917458
LDC111512182
NVL108556280
APLN108741418
PPYR116181069
OTU111413373
CFEL113363253
CCRN123296750
API100161460
DNX107170974
AGS114122020
RMD113560517
ACOO126832801 126832802 126835819 126840514 126840680 126840735 126846771
DVT126905951
BTAB109031372
DCI103506068
CLEC106663477
HHAL106682379
NLU111048726
HVI124370385
MQU128994633
PHUPhum_PHUM563920
FOC113204980
TPAL117653992
ZNE110827948
CSEC111871414
SGRE126365928
IEL124158710
FCD110856840
DPXDAPPUDRAFT_3216
DMK116917637
PVM113816919
PJA122248849
PCHN125026195
PMOO119580337
HAME121869506
PCLA123771723
CQD128698040
PTRU123509330
ESN126983707
HAZT108670333
EAF111714947
LSM121119876
TCF131877665
PPOI119108638
DSV119450253
RSAN119383299
RMP119170433
VDE111248629
VJA111265314
CSCU111618187 111618189
PTEP107440090
UDV129231561
SDM118182631
LPOL106458554 106474155 106475180
LGILOTGIDRAFT_95897
PVUL126829331
PCAN112560883
BGT106060053
GAE121374500 121391533
HRF124133660
HRJ124272289
CRG105336378
CVN111125355
CANU128156280
OED125667268 125682441
MYI110454107
PMAX117329411
MCAF127714207
MMER123557696
RPHI132719110 132724865
DPOL127877671 127880020
OBI106875999
OSN115218557
LAK106167882 106175603
SMMSmp_105040
SHXMS3_00001426(CCRN4L)
OVIT265_04013
NVE5506068
EPA110243529
ATEN116289593 116293651
ADF107328558
AMIL114966105
PDAM113680403
SPIS111337344
DGT114527765
XEN124446063
HMG105845432
HSY130653603
TADTRIADDRAFT_25141
PPP112287324
CRECHLRE_10g448950v5
VCNVOLCADRAFT_98156
MNGMNEG_6331
CSLCOCSUDRAFT_66649
OLUOSTLU_26290
OTAOT_ostta02g01180
BPGBathy11g03490
MISMICPUN_109024
MPPMICPUCDRAFT_42465(JGI:MicpuC2_42465)
GSLGasu_20920
MBRMONBRDRAFT_36891
SREPTSG_04783 PTSG_07643
ACANACA1_215730 ACA1_338400 ACA1_354370
TETTTHERM_00660300 TTHERM_00825610
PTMGSPATT00021689001
SPARSPRG_11328 SPRG_19107
GTTGUITHDRAFT_143708
MFBMFUL124B02_29440
 » show all
Reference
1  [PMID:18391451]
  Authors
Kawai S, Murata K
  Title
Structure and function of NAD kinase and NADP phosphatase: key enzymes that regulate the intracellular balance of NAD(H) and NADP(H).
  Journal
Biosci Biotechnol Biochem 72:919-30 (2008)
DOI:10.1271/bbb.70738
  Sequence
[mja:MJ_0109]
Reference
2  [PMID:29860338]
  Authors
Abshire ET, Chasseur J, Bohn JA, Del Rizzo PA, Freddolino PL, Goldstrohm AC, Trievel RC
  Title
The structure of human Nocturnin reveals a conserved ribonuclease domain that represses target transcript translation and abundance in cells.
  Journal
Nucleic Acids Res 46:6257-6270 (2018)
DOI:10.1093/nar/gky412
  Sequence
[hsa:25819]
Reference
3  [PMID:30389976]
  Authors
Estrella MA, Du J, Korennykh A
  Title
Crystal Structure of Human Nocturnin Catalytic Domain.
  Journal
Sci Rep 8:16294 (2018)
DOI:10.1038/s41598-018-34615-0
  Sequence
[hsa:25819]
Reference
4  [PMID:31147539]
  Authors
Estrella MA, Du J, Chen L, Rath S, Prangley E, Chitrakar A, Aoki T, Schedl P, Rabinowitz J, Korennykh A
  Title
The metabolites NADP(+) and NADPH are the targets of the circadian protein Nocturnin (Curled).
  Journal
Nat Commun 10:2367 (2019)
DOI:10.1038/s41467-019-10125-z
  Sequence
[hsa:25819]
Other DBs
ExplorEnz - The Enzyme Database: 3.1.3.108
IUBMB Enzyme Nomenclature: 3.1.3.108
ExPASy - ENZYME nomenclature database: 3.1.3.108
BRENDA, the Enzyme Database: 3.1.3.108

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