KEGG ENZYME: 3.1.4.56

ENZYME: 3.1.4.56

Entry

EC 3.1.4.56                 Enzyme

Name

7,8-dihydroneopterin 2',3'-cyclic phosphate phosphodiesterase;
MptB

Class

Hydrolases;
Acting on ester bonds;
Phosphoric-diester hydrolases

Sysname

7,8-dihydroneopterin 2',3'-cyclic phosphate 2'/3'-phosphodiesterase

Reaction(IUBMB)

(1) 7,8-dihydroneopterin 2',3'-cyclic phosphate + H2O = 7,8-dihydroneopterin 3'-phosphate [RN:R10344];
(2) 7,8-dihydroneopterin 2',3'-cyclic phosphate + H2O = 7,8-dihydroneopterin 2'-phosphate [RN:R10345]

Reaction(KEGG)

R10344 R10345

Substrate

7,8-dihydroneopterin 2',3'-cyclic phosphate [CPD:C20567];
H2O [CPD:C00001]

Product

7,8-dihydroneopterin 3'-phosphate [CPD:C05925];
7,8-dihydroneopterin 2'-phosphate [CPD:C20566]

Comment

Contains one zinc atom and one iron atom per subunit of the dodecameric enzyme. It hydrolyses 7,8-dihydroneopterin 2',3'-cyclic phosphate, a step in tetrahydromethanopterin biosynthesis. In vitro the enzyme forms 7,8-dihydroneopterin 2'-phosphate and 7,8-dihydroneopterin 3'-phosphate at a ratio of 4:1.

History

EC 3.1.4.56 created 2013

Pathway

ec00790

Folate biosynthesis

ec01100

Metabolic pathways

Orthology

K17487

7,8-dihydroneopterin 2',3'-cyclic phosphate phosphodiesterase

Genes

MJA:

MJ_0837

MFE:	Mefer_0929

MVU:	Metvu_0138

MFS:	MFS40622_1324

MIF:	Metin_0047

MJH:	JH146_1065

MESG:

MLAUSG7_0336(mptB)

MESA:

MLASG1_1515(mptB)

MIG:	Metig_0978

MMP:

MMP0230

MMQ:	MmarC5_1443

MMX:	MmarC6_0723

MMZ:	MmarC7_1232

MMD:

GYY_01170

MMAK:

MMKA1_02360

MMAO:

MMOS7_02630

MMAD:

MMJJ_08310(yhaM)

MAE:

Maeo_0933

MVN:	Mevan_1243

MVO:

Mvol_1222

MOK:	Metok_0345

MKA:

MK0390

IAG:

Igag_1784

THG:	TCELL_0923

HBU:

Hbut_0015

PFM:	Pyrfu_1818

PDL:	Pyrde_0555

PABI:

PABY_03120

PARE:

PYJP_15110

BARB:

AOA66_1470(mptB)

» show all

Reference

1 [PMID:19746965]

Authors

Mashhadi Z, Xu H, White RH

Title

An Fe2+-dependent cyclic phosphodiesterase catalyzes the hydrolysis of 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate in methanopterin biosynthesis.

Journal

Biochemistry 48:9384-92 (2009)
DOI:10.1021/bi9010336

Sequence

[mja:MJ_0837]

Other DBs

ExplorEnz - The Enzyme Database:

3.1.4.56

IUBMB Enzyme Nomenclature:

3.1.4.56

ExPASy - ENZYME nomenclature database:

3.1.4.56

BRENDA, the Enzyme Database:

3.1.4.56

DBGET integrated database retrieval system