Entry
Name
RNA 2',3'-cyclic 3'-phosphodiesterase;
thpR (gene name);
ligT (gene name)
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-diester hydrolases
BRITE hierarchy
Sysname
(ribonucleotide)n-2',3'-cyclic phosphate 3'-nucleotidohydrolase
Reaction(IUBMB)
(ribonucleotide)n-2',3'-cyclic phosphate + H2O = (ribonucleotide)n-2'-phosphate [RN:
R11786 ]
Reaction(KEGG)
Substrate
(ribonucleotide)n-2',3'-cyclic phosphate;
H2O [CPD:
C00001 ]
Product
(ribonucleotide)n-2'-phosphate [CPD:
C21652 ]
Comment
The enzyme hydrolyses RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester. In vitro the enzyme can also ligate tRNA molecules with 2',3'-cyclic phosphate to tRNA with 5'-hydroxyl termini, forming a 2'-5' phosphodiester linkage. However, the ligase activity is unlikely to be relevant in vivo.
History
EC 3.1.4.58 created 2017
Orthology
K01975 RNA 2',3'-cyclic 3'-phosphodiesterase
Genes
ECOO : ECRM13514_0152(yadP)
ECOH : ECRM13516_0155(yadP)
ECW : EcE24377A_0151(ligT)
EDJ : ECDH1ME8569_0141(ligT)
ECOI : ECOPMV1_00153(ligT)
REE : electrica_04186(ligT)
RTG : NCTC13098_06126(ligT)
CLAP : NCTC11466_03782(ligT)
KIE : NCTC12125_02886(ligT)
AHN : NCTC12129_00938(yadP)
PSHI : SAMEA2665130_0444(ligT)
YPG : YpAngola_A1002(ligT)
YPI : YpsIP31758_3336(ligT)
SMW : SMWW4_v1c40920(ligT)
SFJ : SAMEA4384070_4102(ligT)
SOF : NCTC11214_02643(ligT)
PAQU : DMB82_0005715(thpR)
DIC : Dpoa569_000845(thpR)
TPTY : NCTC11468_03043(ligT)
XPE : BJD13_09750 BJD13_11020
XPH : XppCFBP6546_04585(thpR)
XVA : C7V42_06015 C7V42_07435(thpR)
XHD : LMG31886_29520(thpR)
PWI : MWN52_06110 MWN52_08355
LSOL : GOY17_08250 GOY17_11115(thpR)
RHD : R2APBS1_2461 R2APBS1_2478
RTH : LRK53_12970(thpR) LRK53_13035
DJI : CH75_13435 CH75_13675
DTX : ATSB10_02280 ATSB10_13630
DCS : ISN74_05320(thpR) ISN74_13535(thpR)
PAEB : NCGM1900_3451(ligT)
PPUU : PputUW4_03111(ligT)
PTW : TUM18999_19350(ligT)
PAGR : E2H98_05020(thpR) E2H98_16115(thpR)
MARI : ACP86_04530 ACP86_15515
MSHE : MAALD49_29010(ligT)
SCAA : TUM17387_30310(ligT)
SALH : HMF8227_00482(ligT)
LLG : 44548918_00540(ligT)
MISZ : MishRS11D_18700(thpR)
MEIY : MIN45_P0586 MIN45_P1349
TFRI : Thiofri_03335(ligT_1) Thiofri_03435(ligT_2)
TNI : TVNIR_2235(ligT_[H])
THIC : TspCOW1_01400(ligT)
ALCA : ASALC70_00171(ytlP)
MARS : A8C75_06025 A8C75_12775
MRZ : KDW95_06260(thpR) KDW95_10145(thpR)
NCU : F0U83_09625(thpR) F0U83_12140(thpR)
NJP : NEJAP_1485 NEJAP_2719
AEL : NCTC12917_03505(ligT)
CDIZ : CEDIAZO_00806(thpR)
RPU : CDC45_07440 CDC45_12045
RNC : GO999_05100(thpR) GO999_09135(thpR)
RSM : CMR15_11012 CMR15_20651
RPF : Rpic12D_1384 Rpic12D_5153
BCM : Bcenmc03_0384 Bcenmc03_2006
BCH : Bcen2424_0405 Bcen2424_1982
BCEW : DM40_1125 DM40_2625
BMJ : BMULJ_01957 BMULJ_02946(ligT)
BCED : DM42_1416 DM42_3111
BDF : WI26_01645 WI26_09420
BLAT : WK25_00665 WK25_09575
BPSL : WS57_19525 WS57_28470
BSTL : BBJ41_01990 BBJ41_11755
BANN : JFN94_01655(thpR) JFN94_10020
PARA : BTO02_10360 BTO02_18875
PACS : FAZ98_06310(thpR) FAZ98_12670(thpR)
PEW : KZJ38_03225(thpR) KZJ38_13295
BFZ : BAU07_01780 BAU07_10320
AXX : ERS451415_05612(ligT)
VPE : Varpa_2445 Varpa_2930
VBO : CKY39_14560 CKY39_17860
MNR : ACZ75_04340 ACZ75_22160
MENY : LSQ66_10080 LSQ66_18720(thpR)
URU : DSM104443_04175(thpR)
UPL : DSM104440_03700(thpR)
MCI : Mesci_0960 Mesci_5107
MCIC : A4R28_01555 A4R28_23600
MOP : Mesop_0994 Mesop_5693
MAM : Mesau_00988 Mesau_05191
MESM : EJ066_06710(thpR) EJ066_16005
MESP : C1M53_12125(thpR) C1M53_16575
MMEI : LRP31_04320(thpR) LRP31_29575
CHEA : PVE73_02470(thpR) PVE73_19165
AAK : AA2016_0929 AA2016_4914
AMIS : Amn_15400 Amn_53000
RBS : RHODOSMS8_02913(ytlP)
SMEL : SM2011_c03835(ligT)
EMX : FKV68_01910 FKV68_20005(thpR)
ENU : PYH37_002500 PYH37_005714(thpR)
EGI : PZN02_000914 PZN02_001353(thpR)
EAH : FA04_17170 FA04_19290
ENP : JVX98_20950 JVX98_23075(thpR)
AGR : AGROH133_03397 AGROH133_08947(ligT)
ATF : Ach5_02570 Ach5_25640(ligT)
AGT : EYD00_11475(thpR) EYD00_13600
ALF : CFBP5473_02005(thpR)
AVV : RvVAT039_14910(ligT)
AVF : RvVAR031_01940(ligT)
ASAL : CFBP5507_12185(thpR)
RIR : BN877_I0276 BN877_I2764
RPUS : CFBP5875_11810(thpR) CFBP5875_13935
ALEG : CFBP4996_12210(thpR)
REC : RHECIAT_CH0004219(ligT)
RLT : Rleg2_3730 Rleg2_4293
RTR : RTCIAT899_CH01820 RTCIAT899_CH17050
RHV : BA939_07985 BA939_10075
RJG : CCGE525_02170 CCGE525_20040(thpR)
RHR : CKA34_00335 CKA34_04855
RGR : FZ934_15350(thpR) FZ934_17915
RAD : CO657_19090(thpR) CO657_21890
ROY : G3A56_10135 G3A56_12380(thpR)
RII : FFM53_011800 FFM53_014375(thpR)
RRG : J3P73_01740 J3P73_23385(thpR)
RLS : HB780_24020(thpR) HB780_27535
RAW : NE851_11440 NE851_31810(thpR)
RLW : RlegWSM1455_20325(thpR)
ARO : B0909_12120 B0909_25415(thpR)
RBW : RLCC275e_20840(thpR) RLCC275e_23355
NGL : RG1141_CH36540 RG1141_CH44230
NGG : RG540_CH37140 RG540_CH44630
NEN : NCHU2750_34650(ligT)
NPM : QEO92_21580(thpR) QEO92_26365
BIC : LMTR13_22975 LMTR13_37680
BSEP : HAP48_0014195(thpR)
BCAN : BcanWSM471_02035(thpR)
BROS : QUH67_01925(thpR) QUH67_20400
VGO : GJW-30_1_00950(ligT)
BOI : BLM15_07900 BLM15_21540
BVES : QO058_15805(thpR) QO058_29070
LNE : FZC33_19580(thpR) FZC33_33590
MAQU : Maq22A_1p33390(ligT)
MMES : MMSR116_26295(thpR)
HMC : HYPMC_3204 HYPMC_4572
DEA : FPZ08_03050 FPZ08_16110(thpR)
DNP : N8A98_09710(thpR) N8A98_22140
PSTG : E8M01_10725(thpR) E8M01_29635
CCS : CCNA_01713 CCNA_03776
CMB : CSW64_09610 CSW64_19760
CFH : C1707_05565 C1707_17160
CAUF : CSW63_11605 CSW63_22675(thpR)
CAUL : KCG34_02705 KCG34_15025(thpR)
BVY : NCTC9239_03121(ligT)
BGOE : IFJ75_09075 IFJ75_15915(thpR)
SPHK : SKP52_19115 SKP52_21940
SMAG : AN936_19035 AN936_22180
SMAZ : LH19_22915 LH19_25205
SGI : SGRAN_3920 SGRAN_3988(ligT)
SPHQ : BWQ93_14230 BWQ93_16825
SPHX : E5675_03550(thpR) E5675_19790
SINA : KNJ79_17555(thpR) KNJ79_19205
SPHU : SPPYR_0326 SPPYR_3813
SPHD : HY78_09545 HY78_22440
RDI : CMV14_00515 CMV14_17430
SPHM : G432_02570 G432_07720
SSAN : NX02_13155 NX02_26830
SKR : BRX40_00885 BRX40_04585 BRX40_04815
SPLM : BXU08_11825 BXU08_12570
SPHC : CVN68_11425 CVN68_13575 CVN68_19760
SPAP : H3Z74_11675(thpR) H3Z74_21205 H3Z74_21245
SPAI : FPZ24_05545(thpR) FPZ24_16005 FPZ24_16870
SNAP : PQ455_14935(thpR) PQ455_16825
SJP : SJA_C1-07560 SJA_C1-12430(ligT)
SINB : SIDU_08070 SIDU_10015
SCH : Sphch_0219 Sphch_2905
SYB : TZ53_12795 TZ53_21000
SBD : ATN00_00285 ATN00_17150
SPHB : EP837_01874 EP837_02293(ligT)
SPHT : K426_07580 K426_17820
SYA : A6768_14200 A6768_24535
SCLO : SCLO_1016930 SCLO_1031990
SPYG : YGS_C1P1383 YGS_C1P2923
SUFL : FIL70_10190(thpR) FIL70_18310
SBAR : H5V43_07910(thpR) H5V43_15980
SAMI : SAMIE_1003320 SAMIE_1035440
SPPH : KFK14_00340 KFK14_02175(thpR)
SPZR : G5C33_02615 G5C33_05520(thpR)
SMIC : SmB9_05380 SmB9_24580
HADH : FRZ61_33370 FRZ61_49300
AGE : AA314_05180 AA314_09377
AVM : JQX13_07435(thpR) JQX13_40540
PAUU : E8A73_025460(thpR) E8A73_038280 E8A73_040035
PSTI : SOO65_12655 SOO65_20530(thpR)
BAZ : BAMTA208_14730(ytlP)
BSON : S101395_01364(ligT)
BTK : BT9727_1129 BT9727_4435
BFD : NCTC4823_01256(ligT)
PPQ : PPSQR21_011760(ligT)
PNK : AASFL403_13705(thpR)
SMAN : C12CBH8_15690(ligT)
ACEL : acsn021_34580(ligT)
AMIC : Ami3637_00700(thpR)
SRI : SELR_10600 SELR_pSRC100410 SELR_pSRC200640
SANL : KZO11_00155(thpR) KZO11_20915(thpR)
SGRF : SGFS_022950 SGFS_055080
SHO : SHJGH_4542 SHJGH_8036
STRP : F750_4070 F750_6832
SCI : B446_09855 B446_17260
SGU : SGLAU_07685 SGLAU_15205
SVT : SVTN_02245 SVTN_21595
SLC : SL103_32045 SL103_34820
STRM : M444_03920 M444_16035 M444_32335
SCZ : ABE83_15400 ABE83_34370
SRW : TUE45_00534 TUE45_04233(ligT)
SLE : sle_39590(sle_39590)
SGS : AVL59_36325 AVL59_44680
SALW : CP975_01125(thpR) CP975_15515(thpR)
SGM : GCM10017557_37230 GCM10017557_72730
SLS : SLINC_0934 SLINC_3808
SSIA : A7J05_19885 A7J05_32905
SPUN : BFF78_23630 BFF78_31795
SGV : B1H19_04710 B1H19_24705
SLAU : SLA_4275 SLA_4555 SLA_6487
SALF : SMD44_03804(ligT) SMD44_08564(ligT)
SALJ : SMD11_0998 SMD11_2805(ligT)
SLX : SLAV_17280 SLAV_35370 SLAV_35585
SCYA : EJ357_20390(thpR) EJ357_42790
SGZ : C0216_16920(thpR) C0216_28625(thpR)
SVN : CP980_18895(thpR) CP980_31465(thpR)
SRK : FGW37_00785(thpR) FGW37_00960 FGW37_19640(thpR)
SVR : CP971_07615 CP971_14315(thpR) CP971_31315(thpR) CP971_33710
SCAV : CVT27_00145 CVT27_19125
SSUB : CP968_03945(thpR) CP968_18890(thpR)
SCIN : CP977_02610(thpR) CP977_19640(thpR)
SGX : H4W23_02870(thpR) H4W23_03745 H4W23_23010(thpR)
SNF : JYK04_00387(thpR_1) JYK04_01404(thpR_3) JYK04_03955
SBRO : GQF42_12345 GQF42_20715(thpR)
SATA : C5746_01805(thpR) C5746_14775 C5746_23290(thpR)
SHUN : DWB77_01069 DWB77_03516(ytlP)
SCYG : S1361_17965(ligT) S1361_36150
SFEU : IM697_03815(thpR) IM697_27055
SLIA : HA039_03590(thpR) HA039_19630(thpR)
SVD : CP969_03395 CP969_17880(thpR)
SMOB : J7W19_19260(thpR) J7W19_27730
SXN : IAG42_02200(thpR) IAG42_15685(thpR)
SGJ : IAG43_13610(thpR) IAG43_30580(thpR)
SHK : J2N69_00700(thpR) J2N69_15930(thpR)
STRY : EQG64_00390(thpR) EQG64_19890
SGOB : test1122_10245(thpR)
SINE : KI385_00020 KI385_27320(thpR) KI385_43865
SDUR : M4V62_23800(thpR) M4V62_41460(thpR)
SYAN : NRK68_15030(thpR) NRK68_31390(thpR) NRK68_33095
STAA : LDH80_04695(thpR) LDH80_17760(thpR)
SNIG : HEK616_33850 HEK616_63150
STUB : MMF93_00545 MMF93_14695(thpR)
SXT : KPP03845_104275 KPP03845_107005(ytlP)
STUD : STRTU_002792(thpR) STRTU_007119
SGK : PET44_02485(thpR) PET44_14755(thpR) PET44_30775
SYUN : MOV08_17835(thpR) MOV08_38825
SARG : HKX69_01920 HKX69_19320(thpR)
SJN : RI060_00915 RI060_23715(thpR)
SCYN : N8I84_18665(thpR) N8I84_33140
SFIY : F0344_15050(thpR) F0344_34065(thpR)
SROC : RGF97_00270(thpR) RGF97_12620 RGF97_13580(thpR)
SFP : QUY26_01215(thpR) QUY26_22120(thpR)
STTN : BSL84_14760 BSL84_31360 BSL84_33010
SINN : ABB07_21140 ABB07_28995
KAU : B6264_02830 B6264_09350 B6264_26780
KIT : CFP65_4422 CFP65_7640
KIS : HUT16_05075(thpR) HUT16_20565(thpR)
STRH : GXP74_29010(thpR) GXP74_36355(thpR)
ACIJ : JS278_02815(thpR_2)
RAIN : Rai3103_14330(thpR)
NANO : G5V58_18545 G5V58_21400(thpR)
NMES : H9L09_09975(thpR) H9L09_21030
NAQU : ENKNEFLB_00324(ytlP)
NPS : KRR39_07620 KRR39_09450(thpR)
AGRA : AGRA3207_005375(thpR)
CATI : CS0771_17080 CS0771_63890
BALA : DSM104299_02937(thpR)
DEIN : DAAJ005_10725(thpR)
LUO : HHL09_04245 HHL09_19820
LCRE : Pla8534_56060(ligT)
UAM : UABAM_02648 UABAM_06069
PPIO : CE91St28_00490(ligT)
MEMA : MMAB1_0416 MMAB1_0417
HDL : HALDL1_01810 HALDL1_06490
HALA : Hrd1104_08875(thpR)
HARC : HARCEL1_00820(thpR)
HALQ : Hrr1229_007040(thpR)
HACB : Hbl1158_01070(thpR)
TVO : TVG0066474(TVG0066474)
LOKI : Lokiarch_09470 Lokiarch_38300
» show all
Taxonomy
Reference
Authors
Kanai A, Sato A, Fukuda Y, Okada K, Matsuda T, Sakamoto T, Muto Y, Yokoyama S, Kawai G, Tomita M
Title
Characterization of a heat-stable enzyme possessing GTP-dependent RNA ligase activity from a hyperthermophilic archaeon, Pyrococcus furiosus.
Journal
Sequence
Reference
Authors
Remus BS, Jacewicz A, Shuman S
Title
Structure and mechanism of E. coli RNA 2',3'-cyclic phosphodiesterase.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.1.4.58
ExPASy - ENZYME nomenclature database: 3.1.4.58