KEGG   ENZYME: 3.1.4.61
Entry
EC 3.1.4.61                 Enzyme                                 
Name
cyclic 2,3-diphosphoglycerate hydrolase
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-diester hydrolases
Sysname
cyclic 2,3-diphosphoglycerate phosphohydrolyase
Reaction(IUBMB)
cyclic 2,3-bisphosphoglycerate + H2O = 2,3-diphosphoglycerate [RN:R12749]
Reaction(KEGG)
R12749
Substrate
cyclic 2,3-bisphosphoglycerate [CPD:C06189];
H2O [CPD:C00001]
Product
2,3-diphosphoglycerate [CPD:C03339]
Comment
The enzyme degrades cyclic 2,3-bisphosphoglycerate, a thermoprotectant that is produced by certain archaeal genera. Two different enzymes that catalyse this activity, one soluble and one membrane-bound, have been characterized from the archaeon Methanothermobacter thermautotrophicus.
History
EC 3.1.4.61 created 2021
Reference
1  [PMID:1550819]
  Authors
Sastry MV, Robertson DE, Moynihan JA, Roberts MF.
  Title
Enzymatic degradation of cyclic 2,3-diphosphoglycerate to 2,3-diphosphoglycerate in Methanobacterium thermoautotrophicum.
  Journal
Biochemistry 31:2926-35 (1992)
DOI:10.1021/bi00126a012
Reference
2
  Authors
Alebeek G, J.WM., Kreuwels, M.JJ., Keltjens, J.T. and Vogels, G.D.
  Title
Methanobacterium thermoautotrophicum (strain DeltaH) contains a membrane-bound cyclic 2,3-diphosphoglycerate hydrolase.
  Journal
Arch Microbiol 161:514-520 (1994)
Other DBs
ExplorEnz - The Enzyme Database: 3.1.4.61
IUBMB Enzyme Nomenclature: 3.1.4.61
ExPASy - ENZYME nomenclature database: 3.1.4.61
BRENDA, the Enzyme Database: 3.1.4.61

  All links  
Chemical substance (3)   
   KEGG COMPOUND (3)   
Chemical reaction (1)   
   KEGG REACTION (1)   
All databases (4)   

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