| Entry |
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| Name |
N-acetylglucosamine-6-sulfatase;
chondroitinsulfatase;
O,N-disulfate O-sulfohydrolase;
acetylglucosamine 6-sulfatase;
N-acetylglucosamine 6-sulfate sulfatase;
acetylglucosamine 6-sulfatase;
2-acetamido-2-deoxy-D-glucose 6-sulfate sulfatase
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| Class |
Hydrolases;
Acting on ester bonds;
Sulfuric-ester hydrolases
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| Sysname |
N-acetyl-D-glucosamine-6-sulfate 6-sulfohydrolase
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| Reaction(IUBMB) |
Hydrolysis of the 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate [RN: R07808 R07819]
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| Reaction(KEGG) |
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| Comment |
May be identical with EC 3.1.6.11 disulfoglucosamine-6-sulfatase.
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| History |
EC 3.1.6.14 created 1984
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| Pathway |
| ec00531 | Glycosaminoglycan degradation |
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| Orthology |
| K01137 | N-acetylglucosamine-6-sulfatase |
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| Genes |
| CCAN: | 109682634 109689473(Gns) |
| SHR: | 100925460(GNS) 116422552 |
| CMY: | 102930458 102940101(GNS) |
| CCAY: | 125626508 125630246(GNS) |
| DCC: | 119844118(GNS) 119848828 |
| CPIC: | 101939844 101949342(GNS) |
| CABI: | 116821812(GNS) 116830695 |
| MRV: | 120383825(GNS) 120396633 |
| ACS: | 100551899 100554106(gns) |
| PVT: | 110072145 110075098(GNS) |
| SUND: | 121931620(GNS) 121934559 |
| PBI: | 103049496(GNS) 103051498 |
| PMUR: | 107287959 107291795(GNS) |
| CTIG: | 120307409(GNS) 120318805 120319767 |
| TSR: | 106543476 106555618(GNS) |
| PGUT: | 117655550(GNS) 117676051 |
| APRI: | 131201948(GNS) 131203847 |
| PTEX: | 113435974(GNS) 113445820 |
| NSS: | 113412279(GNS) 113428175 |
| VKO: | 123019814(GNS) 123027101 |
| PMUA: | 114602850 114605147(GNS) |
| PRAF: | 128420122 128421881(GNS) |
| ZVI: | 118088022 118090673(GNS) |
| HCG: | 128327578(GNS) 128333502 |
| GJA: | 107107823 107114039(GNS) |
| STOW: | 125434166(GNS) 125442150 |
| EMC: | 129336028(GNS) 129342589 |
| XLA: | 108711078(gns.L) 379953(gns.S) |
| DRE: | 327635(gnsb) 566506(gnsa) |
| SRX: | 107708199 107726052(gns) |
| SANH: | 107656403 107657752 107658640 107658926 |
| SGH: | 107554517 107579236 107579806 107581073 107583955(gns) 107589010 |
| CCAR: | 109062939 109062941 109062988 109071638 109071669 |
| CAUA: | 113047860 113048503 113054636 113054691 113064286 113067919 113110341 |
| CGIB: | 127956407 127966577 127978334 128020787 |
| PTET: | 122333726(gnsb) 122342674(gnsa) |
| LROH: | 127164150(gnsa) 127172489(gnsb) |
| OMC: | 131539504(gnsa) 131548368(gnsb) |
| PPRM: | 120476599(gnsa) 120482716(gnsb) |
| RKG: | 130079953(gnsa) 130094928(gnsb) |
| MAMB: | 125245100(gnsa) 125262409(gnsb) |
| CIDE: | 127510759 127520193 |
| MASI: | 127432585 127433905 127435237 127436725 |
| TROS: | 130546344(gnsb) 130547864(gnsa) |
| TDW: | 130411600(gnsb) 130420325(gnsa) |
| MANU: | 129431691(gnsa) 129446484(gnsb) |
| IPU: | 108277337(gnsb) 108279926(gnsa) |
| IFU: | 128620650(gnsb) 128622983(gnsa) |
| PHYP: | 113532260(gns) 113544942 |
| SMEO: | 124393565(gnsb) 124401767(gnsa) |
| TFD: | 113638427(gnsb) 113645947(gnsa) |
| TVC: | 132859158(gnsa) 132863026(gnsb) |
| AMEX: | 103022579(gns) 103040331 |
| CMAO: | 118812430(gnsa) 118824463(gnsb) |
| EEE: | 113580978(gns) 113583834 |
| CHAR: | 105890433(gnsb) 105898368(gnsa) |
| TRU: | 101067840 101070232(gns) |
| TFS: | 130517221(gnsb) 130519216(gnsa) |
| TNG: | GSTEN00023761G001 GSTEN00025357G001 |
| LCO: | 104931705 104933096(gns) |
| NCC: | 104948056 104951394(gns) |
| TBEN: | 117476439(gnsb) 117484985(gnsa) |
| CGOB: | 115016478 115028236(gns) |
| PGEO: | 117455933(gnsb) 117468370(gnsa) |
| GACU: | 117551280(gnsb) 117552510(gnsa) |
| EMAC: | 134868095(gnsb) 134879161(gnsa) |
| ELY: | 117248948(gnsa) 117269263(gnsb) |
| EFO: | 125883100(gnsa) 125906066(gnsb) |
| PLEP: | 121959862(gnsb) 121961267(gnsa) |
| SLUC: | 116041827(gnsb) 116060209(gnsa) |
| ECRA: | 117938903(gnsa) 117959727(gnsb) |
| ESP: | 116673386(gns) 116686180 |
| PFLV: | 114550189(gns) 114571268 |
| GAT: | 120815168(gnsb) 120816983(gnsa) |
| PPUG: | 119211238(gnsa) 119226387(gnsb) |
| AFB: | 129102230(gnsb) 129112416(gnsa) |
| PSWI: | 130200801(gnsa) 130205159 |
| MSAM: | 119914271(gnsb) 119918060(gnsa) |
| SCHU: | 122865368(gnsb) 122871298(gnsa) |
| CUD: | 121505214(gnsa) 121524998(gnsb) |
| ALAT: | 119030070(gnsb) 119032187(gnsa) |
| MZE: | 101468646(gns) 101474830 |
| ONL: | 100691814(gns) 100701163 |
| OAU: | 116314840(gnsb) 116325487(gnsa) |
| OLA: | 101164824 101172042(gns) |
| OML: | 112154851(gnsa) 112163509(gnsb) |
| CSAI: | 133424612(gnsa) 133455130(gnsb) |
| XMA: | 102224851 102233455(gns) |
| XCO: | 114149340 114161155(gns) |
| XHE: | 116724080 116737168(gns) |
| PRET: | 103459377(gns) 103473209 |
| PFOR: | 103140202(gns) 103151749 |
| PLAI: | 106946394(gns) 106948135 |
| PMEI: | 106915156 106926916(gns) |
| GAF: | 122819289(gnsb) 122826641(gnsa) |
| PPRL: | 129351538(gnsa) 129379847(gnsb) |
| CTUL: | 119790906(gnsb) 119798477(gnsa) |
| GMU: | 124872861(gnsb) 124882717(gnsa) |
| NFU: | 107382500(gns) 107395870 |
| KMR: | 108233312(gnsa) 108245369(gnsb) |
| ALIM: | 106524433(gns) 106526380 |
| NWH: | 119425134(gnsb) 119428271(gnsa) |
| MCEP: | 124996306(gnsB) 125000197(gnsA) |
| POV: | 109626384 109640549(gns) |
| HHIP: | 117757535(gnsa) 117771909(gnsb) |
| HSP: | 118101574(gnsa) 118125462(gnsb) |
| SMAU: | 118292081(gnsa) 118300200(gnsb) |
| LCF: | 108895359(gnsb) 108895933(gnsa) |
| SDU: | 111224796(gns) 111239659 |
| SLAL: | 111659475 111669098(gns) |
| XGL: | 120797913(gnsa) 120806578(gnsb) |
| HCQ: | 109507189 109532622(gns) |
| SSCV: | 125980009 125991952 |
| SBIA: | 133490641(gnsb) 133493607(gnsa) |
| PEE: | 133397260(gnsa) 133413455(gnsb) |
| PTAO: | 133465286(gnsb) 133472290(gnsa) |
| BPEC: | 110161614(gns) 110166676 |
| MALB: | 109952366 109965006(gns) |
| BSPL: | 114861631(gnsa) 114866947(gnsb) |
| SJO: | 128353454(gnsa) 128380695(gnsb) |
| STRU: | 115159890 115189798(gns) |
| OTW: | 112220124(gnsb) 112240493 121844647 |
| OMY: | 110511600 110523334(gnsb) 118942865 |
| OGO: | 123989342(gnsb) 124019611 |
| OKI: | 109868229 109887151 116371811 |
| OKE: | 118378093(gnsb) 127924961 |
| CCLU: | 121558509(gnsa) 121582128(gnsb) |
| ELS: | 105007344 105007789(gns) |
| SFM: | 108920982(gns) 108935811 |
| PKI: | 111849756 111851442 111859045(gns) |
| AANG: | 118206940 118212860 118232018(gnsa) |
| LOC: | 102685371 102693153(gns) |
| ARUT: | 117416020 117419996 |
| PSEX: | 120538823(gnsb) 120539685(gnsa) |
| CMK: | 103186133(gnsa) 103187768 |
| RTP: | 109929374(gnsb) 109933529(gnsa) |
| CPLA: | 122543110(gnsb) 122559724(gnsa) |
| HOC: | 132824905(gnsa) 132836836(gnsb) |
| LERI: | 129706463(gnsa) 129713195(gnsb) |
| PMRN: | 116947413 116951244 |
| LRJ: | 133351820(GNS) 133356570 133356571 |
| DME: | Dmel_CG18278(CG18278) Dmel_CG30059(CG30059) |
| DSI: | Dsimw501_GD25763(Dsim_GD25763) |
| TDA: | 119669353 119669358 119669362 |
| AGB: | 108908534 108908543 111691362 |
| MCIX: | 123663394 123663402 |
| LSIN: | 126975679 126975680 126975681 |
| SGRE: | 126336642 126336643 |
| PPOI: | 119096059 119096252 |
| LGI: | LOTGIDRAFT_208806 LOTGIDRAFT_238806 |
| PVUL: | 126824538 126825206 |
| PCAN: | 112559084 112559345 |
| HRF: | 124116039 124116040 124116042 124117774 124117782 |
| HRJ: | 124254025 124254029 124281890 124281891 |
| DPOL: | 127833955 127871205 |
| LAK: | 106157766 106157770 106163980 106166031 |
| AQU: | 100637984 100640152 105312223 |
| VCN: | VOLCADRAFT_104983(ars1) |
| FVR: | FVEG_00102 FVEG_11177 |
| NHE: | NECHADRAFT_42509 NECHADRAFT_45116 NECHADRAFT_95823 |
| PLJ: | VFPFJ_02907 VFPFJ_07622 |
| ELA: | UCREL1_10896 UCREL1_6012 UCREL1_711 |
| PFY: | PFICI_00717 PFICI_00803 PFICI_05380 PFICI_06323 PFICI_08657 PFICI_15110 |
| URE: | UREG_04509 UREG_07890 |
| AALT: | CC77DRAFT_1042949 CC77DRAFT_202654 |
| NPA: | UCRNP2_1611 UCRNP2_5515 |
| SHS: | STEHIDRAFT_126811 STEHIDRAFT_126817 |
| MRR: | Moror_2117 Moror_7800 |
| MBR: | MONBRDRAFT_24514 MONBRDRAFT_29207 MONBRDRAFT_29950 MONBRDRAFT_849 |
| SRE: | PTSG_10494 PTSG_11248 PTSG_12796 |
| FCY: | FRACYDRAFT_157083(GNS1_1) FRACYDRAFT_247897(GNS2_1) |
| AAF: | AURANDRAFT_12528 AURANDRAFT_27956 AURANDRAFT_29931 AURANDRAFT_62077 AURANDRAFT_65638 |
| EHX: | EMIHUDRAFT_100471 EMIHUDRAFT_196221 EMIHUDRAFT_201189 EMIHUDRAFT_215588 EMIHUDRAFT_225471 EMIHUDRAFT_470091 |
| NDK: | I601_1074(betC_2) I601_2139(betC_4) |
| NOI: | FCL41_00895 FCL41_16560 |
| NOW: | GBF35_30840 GBF35_39565 |
| RUB: | GBA63_04165 GBA63_14630 |
| GIM: | F1728_02560 F1728_07040 |
| GPN: | Pan110_15320(betC_2) |
| ABAC: | LuPra_00356(betC_2) |
| CBAL: | M667_00095 M667_09680 |
| CBAT: | M666_00095 M666_09605 |
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| Reference |
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| Authors |
Basner R, Kresse H, von Figura K. |
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| Title |
N-Acetylglucosamine-6-sulfate sulfatase from human urine. |
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| Journal |
J Biol Chem 254:1151-8 (1979) |
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| Reference |
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| Authors |
Kresse H, Fuchs W, Glossl J, Holtfrerich D, Gilberg W. |
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| Title |
Liberation of N-acetylglucosamine-6-sulfate by human beta-N-acetylhexosaminidase A. |
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| Journal |
J Biol Chem 256:12926-32 (1981) |
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| Reference |
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| Authors |
Weissmann B, Chao H, Chow P. |
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| Title |
A glucosamine O,N-disulfate O-sulfohydrolase with a probable role in mammalian catabolism of heparan sulfate. |
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| Journal |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 3.1.6.14 |
| ExPASy - ENZYME nomenclature database: | 3.1.6.14 |
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