Entry |
|
Name |
chondro-4-sulfatase;
chondroitin-4-sulfatase;
4-deoxy-beta-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine-4-sulfate 4-sulfohydrolase
|
Class |
Hydrolases;
Acting on ester bonds;
Sulfuric-ester hydrolases
|
Sysname |
4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine-4-sulfate 4-sulfohydrolase
|
Reaction(IUBMB) |
4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine 4-sulfate + H2O = 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine + sulfate [RN: R03517]
|
Reaction(KEGG) |
|
Substrate |
4-deoxy-beta-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine 4-sulfate [CPD: C04864];
H2O [CPD: C00001]
|
Product |
4-deoxy-beta-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine [CPD: C01310];
sulfate [CPD: C00059]
|
Comment |
Also acts on the saturated analogue but not on higher oligosaccharides, nor any 6-sulfates.
|
History |
EC 3.1.6.9 created 1972
|
Reference |
|
Authors |
Held E, Buddecke E. |
Title |
[Studies on the chemistry of the arterial wall, XI. Demonstration, purification and properties of a chondroitin-4-sulfatase from bovine aorta] |
Journal |
Hoppe Seylers Z Physiol Chem 348:1047-60 (1967) |
Reference |
|
Authors |
Roy AB. |
Title |
Sulphatases, lysosomes and disease. |
Journal |
|
Reference |
|
Authors |
Yamagata T, Saito H, Habuchi O, Suzuki S. |
Title |
Purification and properties of bacterial chondroitinases and chondrosulfatases. |
Journal |
J Biol Chem 243:1523-35 (1968) |
Other DBs |
ExplorEnz - The Enzyme Database: | 3.1.6.9 |
ExPASy - ENZYME nomenclature database: | 3.1.6.9 |
BRENDA, the Enzyme Database: | 3.1.6.9 |
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